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Biomedical subjects

S Corcione

Publications and source records attributed to S Corcione.

30 records · Page 2Linked to original sources
PubMed1983

[Electrolyte and osmolar changes during extracorporeal ultrafiltration of hepatic cirrhosis ascites].

Ultrafiltration of ascitic fluid with intraperitoneally reinfusion of concentrate was performed on 4 patients with hepatic cirrhosis and ascites. Ascites was removed, ultrafiltered using a parallel plate dialyzer and returned to the peritoneal space via a single catheter. A mean of 4693 ml (range 2000ml-8000ml) of protein free ascitic fluid was removed over the 2-3 hour period of ultrafiltration without evidence of worsening hypovolemia or deterioration of renal function.

Aged↗
PubMed1983

[Clinical study of patients with primary polyarthritis. Cross-over comparative study of proglumetacin and naproxen].

Proglumetacin at low-dose (300 mg/day) and naproxen (500 mg/day) were used in a crossover study in 20 patients with primary polyarthrosis. Each drug was administered during 1 week without between drugs. Both drugs resulted effective in the management of the most disturbing symptoms, without significant differences. Tolerance was also superimposable, as the few reported complaints were recorded under both treatments and appeared rather related to the patient than to the drug. Proglumetacin therefore, even when given at low dose, resulted at least as effective as an established treatment for polyarthrosis, while confirming its very good tolerance, so as to appear well suited for the general management of patients with such degenerative-reactive disorders.

Aged↗
PubMed1983

[The acromegalic hand. Diagnostic value of various radiographic measurement indices].

The first classic description of so-called "spade hand" in acromegaly dates from 1886 and is reported by Marie [22]. The hand radiograph is easily diagnostic, when gross abnormalities are present. Sometimes, however, it may be difficult to distinguish the appearances of the milder case from the normal, only by X-ray. The aim of this paper is to define the position of several hand measurements (sesamoid index, tufting, joint space thickness, hand length, metacarpal index, soft tissue measurements at index finger) and to compare these indices in relation to the detection of disease in radiological diagnosis. Hand measurements were made in 100 normal controls and in 19 cases of acromegaly, of whom hand radiograph and xerograph were performed and also compared each others.

Acromegaly↗
PubMedDate not supplied

Sentinel node study in early breast cancer.

Since October 1997 60 patients with early breast cancer (T <3 cm) were studied. All patients underwent lymphoscintigraphy with two types of colloid: the first (17 pts) with a particle size <1,000 nm; the second (43 pts) with a particle size <80 nm. The standard procedure consists of injection, on the day before surgery, of 70 MBq of the smaller nanocolloid in 0.4 cc saline divided over four sites, around the lesion or subdermally around the surgical scar. We utilize a low-energy, high-resolution LFOV camera for scintigraphy and a probe specific for the sentinel node during surgery. In 56/60 patients (93.3%) lymphoscintigraphy showed the sentinel node (SN). In two cases the SN was not detected presumably because of lymphatic interruption by an old surgical scar; in the other two cases the sites of injection were too close to the SN, thus masking it. In five cases (9%) the SN was not visualized with the surgical probe but in two of these drainage to the internal mammary chain was observed. The apparently lower sensitivity of intraoperative localization was due to the extra-axillary lymphatic drainage or to the vicinity of the SN to the primary lesion. The SN proved to be metastatic in 12 cases. No false-negative SNs were found. In five cases (10%) the radiolabeled lymph node was the only node containing tumor cells (micrometastases): this result depends on the combined use of hematoxylin-eosin and rapid cytokeratin staining. The application of blue dye was useful for easier identification of the SN but did not allow detection of more SNs. Our preliminary results are extremely encouraging. Considering that at the early stages of breast cancer the likelihood of lymph node metastases is low (20% in our series) and no false negative were reported in this study, we conclude that with SN biopsy axillary lymph node dissection can be avoided, making surgery less aggressive but maintaining accuracy.

Adult↗
PubMedDate not supplied

Sentinel node biopsy in the evaluation of the internal mammary node chain in patients with breast cancer.

AIMS AND BACKGROUND: In patients with breast cancer the presence of internal mammary chain (IMC) metastases changes tumor staging, and the occurrence of IMC drainage is quite common in breast cancer. Nevertheless, IMC dissection is not a routine procedure in modern surgical approaches towards breast cancer. We therefore need minimally invasive techniques for accurate assessment of the IMC nodal basin. The aim of this study was to investigate whether sentinel node biopsy (SLNB) could offer a solution. METHODS AND STUDY DESIGN: From November 1997 to June 2001 143 female patients who were eligible for breast cancer surgery were included in the study. All patients had T1 breast cancer and clinically negative axillae. Patients were submitted to preoperative lymphoscintigraphy with subsequent SLNB. We used a 99m-technitium nanocolloid tracer (Nanocoll) that was injected peritumorally so as to have about 10 MBq of radioactivity at the time of surgery. Scintigraphy was performed about 17 hours after tracer administration. During surgery, lymphoscintigraphic imaging and a gamma ray detection probe were used to locate the sentinel node. Histological examination after embedding in paraffin was usually requested and multilevel sectioning of the sentinel node (SLN) was performed, with hematoxylin and eosin staining and immunohistochemistry. RESULTS: Preoperative lymphoscintigraphy localized SLNs in the IMC basin in 27 of 143 patients (18.9%). Harvesting of IMC-SLNs based on lymphoscintigraphy results was successful in 20 of 27 patients (74.1%). Histological examination revealed micrometastases in four of the 20 harvested nodes. One of these patients showed no axillary drainage and no axillary lymph node dissection was therefore performed. In the remaining three patients also axillary SLNs were harvested, which turned out to be free from metastatic involvement. CONCLUSIONS: In our experience lymphoscintigraphy with SLNB was an accurate method to detect IMC metastases in patients with breast cancer. We recommend peritumoral tracer injection and a reasonable interval between injection and scintigraphy. IMC-SLN biopsy did not result in any serious additional complications or morbidity. In our study this approach led to improved cancer staging: four of 20 harvested IMC-SLNs proved to be micrometastatic. None of these four patients had metastatic axillary SLNs. Exclusive drainage to the IMC is present in only a small number of breast cancer patients, and our results suggest that it is possible to avoid unnecessary axillary node dissection in such cases.

Adult↗