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Biomedical subjects

S Cook

Publications and source records attributed to S Cook.

185 records · Page 11Linked to original sources
PubMedDate not supplied

Functional ambulation in myelodysplasia: the effect of orthotic selection on physical and physiologic performance.

The metabolic demands of ambulation in a reciprocation gait orthosis (RGO) were compared with those in conventional bracing (hip-knee-ankle-foot orthosis) and wheelchair use in eight myelodysplastic children. Heart rate was significantly increased during swing-through gait compared with that during wheelchair use (p less than 0.01). Oxygen consumption studies showed a significant increase in swing-through gait over that in wheelchair use. These values for RGO use approximated wheelchair use. These results suggest a more favorable prognosis for long-term functional ambulation in higher-level myelodysplastic patients if they are fitted with an RGO.

Adult↗
PubMedDate not supplied

Development of a knowledge test in the science of prevention of lung diseases.

We developed a 50-item multiple choice test to assess knowledge of preventive pulmonary medicine. We derived the content of test items from a comprehensive preventive pulmonary curriculum, which we developed. The test was administered to 167 medical students, residents, and practicing physicians to establish its psychometric properties and to determine if the test scores discriminated between different levels of training. Using this sample, the reliability of the test was 0.86, and the test significantly differentiated between levels of training in pulmonary medicine. We are using this multiple choice test to assess changes in knowledge of second-year medical students and of fourth-year medical students completing a pulmonary medicine elective rotation.

Curriculum↗
PubMedDate not supplied

Onset of protective immunity in chicks after vaccination with a recombinant herpesvirus of turkeys vaccine expressing Newcastle disease virus fusion and hemagglutinin-neuraminidase antigens.

The onset of protective immunity from lethal Newcastle disease virus (NDV) challenge of chicks was determined after vaccination with a recombinant herpes virus of turkeys (HVT) expressing the fusion and hemagglutinin-neuraminidase proteins of NDV. One-day-old specific-pathogen-free chicks devoid of maternal antibodies to NDV were vaccinated with 130 to 3300 plaque forming units of HVT (depending on the trial) and then challenged at 4, 7, 10, and 14 days postvaccination (DPV) with a neurotropic velogenic strain of NDV (GB Texas). The recombinant vaccine afforded 0%, 35-75%, 85%, and 94-100% protection when the vaccinated birds were challenged at 4, 7, 10, and 14 DPV, respectively. In all trials, challenge caused 100% mortality in unvaccinated control chicks. Newcastle disease virus was reisolated from the lung, liver, spleen, and brain of birds dying in all trials regardless of vaccine dosage or time of challenge, except when challenge occurred at 14 DPV.

Animals↗