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Biomedical subjects

S Coleman

Publications and source records attributed to S Coleman.

79 records · Page 5Linked to original sources
PubMedDate not supplied

Isolation and characterization of two benzene-derived hemoglobin adducts in vivo in rats.

The present study was aimed at the characterization of the major adducts formed by reaction of the metabolites of [14C]benzene with rat hemoglobin in vivo. Groups of 12-week-old male Fisher rats received i.p. injections of a single dose of 10 mmol/kg body weight or three equal daily subdoses of 3.3 mmol/kg body weight of [14C]benzene. High-performance liquid chromatographic analysis of strong acid hydrolysates of the [14C]benzene-modified globin indicated that the two major adducts in rats cochromatographed with synthetic S-(2,5-dihydroxyphenyl)cysteine and S-phenylcysteine. These adducts were converted to O,O'-S-tris-acetyl-3-thiol-hydroquinone and S-phenylthioacetate, which were then characterized by gas chromatography/mass spectrometry. The major radioactive adduct peaks accounted for 60-75% of the total radioactivity associated with rat globin. Characterization of the S-(2,5-dihydroxyphenyl)cysteine adduct provides evidence that p-benzoquinone is formed as a reactive metabolite of benzene. Formation of the S-phenylcysteine adduct indicates that benzene oxide and/or a hydroxycyclohexadienyl free radical is formed as an active intermediate upon i.p. injection of benzene into rats.

Animals↗
PubMedDate not supplied

Recommendations for improving cardiopulmonary resuscitation skills retention.

Massive community efforts are devoted to delivering cardiopulmonary resuscitation (CPR) training to health professionals and lay people. However, although most people can successfully learn to perform CPR, skills retention is universally poor. Beginning as early as 2 weeks after initial training, CPR skills begin to deteriorate in a wide variety of subjects including nurses, physicians, emergency medical technicians, family members of patients with cardiac disease, and other lay people. Methods tested to improve retention are reviewed, and the role of practice and review is examined. The failure of many factors to improve retention of CPR skills is discussed. Finally, suggestions for improvement in retention of CPR skills based on a review of the literature and pertinent theory are offered.

Cardiopulmonary Resuscitation↗
PubMedDate not supplied

Comparing methods of cardiopulmonary resuscitation instruction on learning and retention.

This article describes a study of two methods of teaching CPR where immediate and long-term retention of CPR skills and knowledge were compared. Forty-nine subjects were randomly assigned to either a control group (didactic instruction) or an experimental group (modular instruction). Knowledge retention was evaluated by means of a written examination. Skills retention was evaluated by the Mandel observation instrument. The knowledge and skills performance of both groups, immediately following the class and at 3 months follow up, were not significantly different. Based on these results, modular instruction appears to be an effective alternative to the conventional time-consuming and expensive method commonly used for CPR instruction.

Adult↗
PubMedDate not supplied

Playing games with cardiopulmonary resuscitation.

The authors describe the process used to incorporate gaming into a level "A" cardiopulmonary resuscitation course. Needs assessment, planning, implementation, and evaluation phases are presented. Staff development instructors can use gaming, an interactive means of instruction, to teach a level "A" cardiopulmonary resuscitation (Heartsaver) course.

Cardiopulmonary Resuscitation↗
PubMedDate not supplied

Comparison of perceived symptoms of patients undergoing bone marrow transplant and the nurses caring for them.

This study describes the symptomatology of patients hospitalized for bone marrow transplant (BMT) (n = 30) and compares their perceptions of these symptoms to those of nurses (n = 28). Patients and nurses responded to the Symptom Distress Scale (SDS) four times: within 48 hours of BMT day one (T1); day 7-10 post-BMT (T2); day 20-23 post-BMT (T3); and day 30-34 post-BMT (T4). Patients also completed the Profile of Mood States at T1. Each time, the investigators completed a Karnofsky Performance Status evaluation of each patient. Patients perceived significantly more distress from their symptoms at T1 than their nurses perceived that they were experiencing. Over time, patients' SDS scores did not change significantly. However, nurses' SDS scores indicated significant differences, with their SDS scores at T1 less than those at T2 and T3. The results indicate the importance of nurses exploring the perceived symptom experiences of patients undergoing BMT. Any incongruence between nurses' and patients' perceptions potentially could prevent patients' symptoms from being managed effectively.

Activities of Daily Living↗