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Biomedical subjects

S Chandran

Publications and source records attributed to S Chandran.

At least 37 records · Page 2Linked to original sources

A trial of baby check scoring system to identify high-risk infants in a polyclinic in Oman.

The baby check score card was used in a busy polyclinic to identify babies with different grades of illness attending as out-patients. A total of 90 paediatric patients in the age group 1 to 6 months were screened during February to June 1995. These patients were seen by the junior physicians. They filled in the score card and graded the illness, as they perceived, into well or mild, moderate, and severe. The scores, as described by the original authors, were then assigned to the various signs and symptoms recorded in the score card, by the investigators. The total scores obtained were correlated with the grades of illness (grade 1-well or mild, grade 2-moderate, and grade 3-severe). The scores ranged from 0 to 41. Forty-three cases were well or mildly ill; 41 moderately ill; and six seriously ill. The scores generally correlated with the grades of illness. Those with lower scores had milder illness and were sent home with reassurance. Six cases who were seriously ill all scored over 20 and were referred for tertiary care. The scoring system appeared to be fairly accurate in identifying high-risk infants. It could be used as a valuable tool for screening infants for severity of illness with reasonable accuracy in our set-up.

Ambulatory Care Facilities↗

Recent trends in drug delivery systems: liposomal drug delivery system--preparation and characterisation.

Liposomes are potential drug carriers for variety of drugs, therapeutic proteins and diagnostic agents. Drug entrapment ability of liposomes makes it more useful in targetting of drugs to specific site within the body. Major components of liposomes include lipids, water, drugs, electrolytes, antioxidants, preservatives and viscosity inducing agents. Considering the widespread use of liposomes in drug therapy and problem of physico-chemical instabilities of liposomes, this article aims at giving an insight into various methods of preparation of different types of liposomes like, unilamellar and multilamellar vesicles, consideration of some critical aspects of manufacturing processes and the characterization of liposomal drug delivery system in reference to vesicle size distribution, determination of residual organic phase in the phospholipid bilayer system, per cent drug encapsulation and identification.

Drug Carriers↗

Chondroid syringoma-scalp. A case report.

A case of chondroid syringoma of scalp is reported. The case is of particular interest because of repeated recurrence with bone and dural infiltration.

Adenoma, Sweat Gland↗

Hypopyon--an early sign of leukaemic relapse.

A 5-year-old girl with ALL developed leukaemic hypopyon after 33 months of treatment. Bone marrow and CNS relapse developed 3 months later, which was successfully treated. Local radiotherapy did not prevent an ocular relapse 2 months later, and a second course of irradiation was successfully given. She developed a second bone marrow relapse and died about 9 months after hypopyon was first identified. It is postulated that hypopyon may be an early sign of leukaemic relapse.

Anterior Chamber↗