Biomedical subjects

S Chadha

Publications and source records attributed to S Chadha.

39 records · Page 3Linked to original sources

PubMedDate not supplied

Auditory brainstem responses in high risk and normal newborns.

We studied the auditory brainstem responses of 50 high risk neonates from NICU and compared with those of 25 normal neonates in order to determine the percentage of significant auditory impairment in NICU and correlated it to various risk factors. Infants with the risk factors of low birth weight, hyperbilirubinemia, asphyxia, septicemia and meningitis were included in the study group. All the 150 ears were tested at 4 intensities 30 dB, 46 dB, 60 dB and 75 dB. The study recorded prolongation of latency of wave V and I-V Interwave interval in the study group with a statistically significant difference denoting an impaired condition. Incidence of significant auditory impairment was 18%. On follow up at 6 months incidence of persistent auditory abnormality was 4%. On the basis of this study it is suggested that all high risk neonates should undergo screening for hearing impairment.

Auditory Diseases, Central↗

PubMedDate not supplied

Effect of mechanical removal of the pulp upon the retention of odontoblasts around the pulp chamber of human third molars.

The pulp chambers of 11 freshly extracted human third molars were exposed by cutting off the roots apical to the cervical margin and the pulps were either removed with forceps and discarded or left in situ. The teeth were fixed, demineralized, divided longitudinally, embedded in resin and 2-micron sections stained with toluidine blue were examined by light microscopy. In pulp-removed specimens the percentage retention of the odontoblast layer with the predentine varied near the longitudinal division but when sectioned deeper all six specimens displayed 100% retention. The intactness of the retained odontoblast layer was mostly good as judged by the mutual close apposition of the distal ends of the cell bodies and their relation to the predentine. The retention of the odontoblast layer with the predentine may be due to the distribution of fibronectin, which others have shown is present between odontoblasts, and between odontoblasts and predentine, but lacking beneath the odontoblast layer.

Cell Adhesion↗

PubMedDate not supplied

Effect of selected metal ions on the motility and carbohydrate metabolism of ejaculated human spermatozoa.

Zinc, lead and cadmium in the form of chloride salts when added to a standard assay system containing 80 X 10(-6) ejaculated washed human spermatozoa caused a dose and duration-dependent inhibition of their motility. The activity of certain key enzymes of carbohydrate and energy metabolism, viz, glycogen phosphorylase, glucose-6-phosphatase, fructose-1, 6-diphosphatase, glucose-6-phosphate isomerase, amylase, Mg2+- dependent ATPase and lactic and succinic acid dehydrogenases were also found to be inhibited. The order of inhibitory effects of the heavy metals were zinc less than lead less than cadmium. The metal chelating agent, ethylene diamine tetra-acetic acid (EDTA, disodium salt) also interfered with the spermatozoal motility and inhibited the enzyme activities.

Cadmium↗