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S Castaigne

Publications and source records attributed to S Castaigne.

123 records · Page 7Linked to original sources
PubMed1984

[Hairy cell leukemia: study of the development of 211 cases].

Large series of patients with hairy cell leukaemia have only recently been published. The 211 cases reported here provide useful information on the clinical presentation, prognostic factors, evolution and management of this uncommon disease. At presentation, 28% of the patients had no spleen enlargement, and only 20% had severe pancytopenia. However, severe neutropenia (less than 0.5 X 10(9)/l) was present in 32% of the cases. Prognosis was primarily related to the degree of peripheral cytopenia, usually corrected by splenectomy, but it was poor in both non-splenomegalic and splenectomized patients with persistent anaemia and neutropenia, and it is in these patients that other treatments should be tested.

Adult↗
PubMed1984

Promyelocytic blast crisis of chronic myelocytic leukemia with both t(9;22) and t(15;17) in M3 cells.

A blast crisis with the features of promyelocytic leukemia (M3) occurred during the evolution of chronic myelocytic leukemia (CML) with the t(9;22) translocation. This rare form of transformation was confirmed by means of cytologic and electron microscopic examination. Cytogenetic studies showed two simultaneous translocations t(15;17) and t(9;22) in the promyelocytes. After intensive chemotherapy, a complete remission was obtained and only karyotypes with t(9;22) translocation were present. These data confirm the specificity of the t(15;17) translocation in malignant promyelocytic proliferation and provide evidence for a second genetic event in the genesis of blast crisis occurring in a committed cell belonging to the abnormal population defined by the Ph1 chromosome.

Bone Marrow↗
PubMed1983

[Herpesvirus infections during treatment inducing remission of acute leukemia].

Herpes virus hominis infection was observed in 28% (diagnosis ascertained on viral examination) to 33% (clinical suspicion) of 36 adult patients prospectively studied during remission induction chemotherapy for acute leukaemia. Symptoms are non specific so that diagnosis relies upon viral isolation. All infected patients but one survived the viral infection and the prognosis of the underlying acute leukaemia was unaffected.

Acute Disease↗
PubMed1983

[Herpes virus infections during a remission induction treatment in acute leukemias].

Herpes virus hominis infection was observed in 28% (diagnosis assessed on viral examination) to 33% (clinical suspicion) of 36 adult patients prospectively studied during remission induction chemotherapy for acute leukaemia. Symptoms are non specific so that diagnosis relies upon viral isolation. All infected patients but one survived the viral infection and the prognosis of the underlying acute leukaemia was unaffected.

Acute Disease↗
PubMed1983

[Lesions evoking Sweet's syndrome in acute leukemia: occurring during the stage of therapeutic aplasia].

Acute febrile neutrophilic dermatosis, so called Sweet's Syndrome is a distinct dermatological disease defined by constant clinical and histological features: Eruption of painful, tender, raised erythematous plaques of face and neck with fever. Dense dermal infiltration with mature neutrophil polymorphs. Sweet's Syndrome may occur during the course of chronic or acute haematological diseases such as chronic myelogenous leukemia or acute non lymphoblastic leukemia. In all cases, the counts of Neutrophil Polymorphs were normal or above normal limits. We report a case of Sweet's Syndrome occurring during the aplastic period induced by the treatment of an acute myelo monocytic leukemia, and discuss the responsibility of white blood cells transfusion in genesis of typical histological aspect.

Female↗
PubMed1983

Does treatment with ARA-C in low dosage cause differentiation of leukemic cells?

A series of 21 patients (5 refractory anemias with an excess of blasts in transformation and 16 acute leukemias) were treated with small doses of ARA-C (10 mg/sq m/12 hr for 15-21 days). Improvement was noted in 15 cases (71%) and complete remission observed in 12 (57%). Complete remission was obtained after one course of treatment in 8 cases. The fact that these patients entered remission relatively slowly and did not suffer marrow aplasia suggests that low-dose ARA-C may function in vivo as it does in vitro, i.e., by inducing differentiation of leukemic blasts.

Acute Disease↗
PubMed1982

[Acute respiratory failure disclosing bilateral diaphragmatic paralysis].

In the case of three patients an acute respiratory failure with alveolar hypoventilation is related to bilateral diaphragmatic paralysis apparently isolated from any other neurologic abnormalities. The current initial diagnosis of pulmonary embolism leading to admission in an intensive respiratory care unit, because of the severity of the acute respiratory failure, has to be rectified then. Bilateral diaphragmatic paralysis is suspected on account of the absence of any patent etiology, on increasing dyspnea in supine position and paradoxic movements of the upper abdomen (whether spontaneously or in attempted weaning of ventilation support). Bilateral diaphragmatic paralysis is asserted by electromyogram with measurement of nerve conduction velocities of the two phrenic nerves. In the first case, it appears early in the course of an amyotrophic lateral sclerosis; in the second case, it occurs before the presence of a herpes-zoster becomes patent. In the third case, paralysis seems to be idiopathic. Evolution is promising in the last two cases, owing to the reversibility of the lesions. The difficulty of diagnosis, the varying nature of etiology and prognosis encountered in these three cases are also apparent in the 15 cases published in medical literature. The small number of cases published up to now, contrasting with the cases we have witnessed over the last 3 years, leads us to think that this disease must exist more often and may remain unknown to us.

Adult↗
PubMed1981

[Hairy cell leukaemia with severe bone marrow insufficiency. Complete remission after chemotherapy in two patients (author's transl)].

Comple remission was obtained in two patients with hairy cell leukaemia and severe bone marrow insufficiency, using combined chemotherapy (rubidazone, arabinosyl cytosine, 6-mercaptopurine and cyclophosphamide). The remissions -- as demonstrated by normal blood cell counts and differentials and complete disappearance of hairy cells and fibrosis in bone marrow biopsies -- have now persisted for 6 and 3 months respectively. Intensive chemotherapy should be considered in patients who, after splenectomy, still have severe bone marrow depletion with persistent anaemia, neutropenia and/or life-threatening thrombocytopenia. Protected environment in a haematology intensive care unit is a prerequisite of intensive chemotherapy in such patients.

Antineoplastic Agents↗