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Biomedical subjects

S Cabili

Publications and source records attributed to S Cabili.

49 records · Page 3Linked to original sources
PubMed1982

Lack of an effect of saline loading on glycerol-induced acute renal failure.

To determine whether saline loading actually protects against acute renal failure, both C and BUN were measured in rats drinking either tap water or 1% saline for 1-3 months. At 24 and 48 h after an injection of 10 ml/kg i.m. of 50% glycerol in water, CTN was equally reduced in saline-drinking and water-drinking rats as compared to uninjected rats. The daily intraperitoneal injection of saline for 1-3 months also was not protective. At 48 hours after glycerol injection, the BUN concentration in saline-drinking rats was significantly lower than in water-drinking rats. This was probably due to the greater renal urea clearance in these animals. We conclude from these findings that saline loading does not protect against glycerol-induced acute renal failure in the rat although it affects the Curea and Bun concentration.

Acute Kidney Injury↗
PubMed1982

Intrarenal vascular sclerosis in IgA nephropathy.

In this analysis of 43 patients with IgA nephropathy, renal morphology was correlated with clinical data. Gross hematuria and mild proteinuria were typical among younger patients. Among older individuals the clinical spectrum was wider. A comparison with data previously obtained from the normal population indicated that disease-related glomerular sclerosis was present in 1/3 of initial biopsy specimens. The prevalent pattern of glomerular sclerosis was that of global tuft collapse, the type of sclerosis known to result from ischemia. Intrarenal vascular sclerosis was present in 1/3 of initial biopsies. Follow-up specimens from 6 patients showed progression of glomerular sclerosis, vascular sclerosis or both. Hypertension occurred in over 1/4 of patients. It is proposed that progressive renal damage in IgA nephropathy may not be solely immunologically mediated. Glomerular sclerosis may also be mediated by vascular sclerosis, or alterations in intrarenal hemodynamics in glomerulonephritis may have a direct damaging effect on both the glomerulus and the intrarenal vasculature.

Adolescent↗
PubMed1981

Changes in cardiovascular and renal function during catecholamine infusions in developing swine.

Renal and cardiac effects of norepinephrine and dopamine were evaluated in swine aged 1 wk, 2 wk, and 6 mo. The swine were anesthetized with pentobarbital (20-30 mg/kg). Aortic pressure, right ventricular pressure and its first derivative, and heart rate were recorded, together with carotid and renal (RBF) arterial flows. Glomerular filtration rate (GFR) was determined by [14C]inulin clearance. After a control period, norepinephrine or dopamine was infused intravenously for 10-20 min before and then during another clearance period. After a second control period, the second catecholamine was infused. GFR increased in piglets given either catecholamine. Norepinephrine at equipressor doses (2.0 micrograms.kg-1.min-1 in piglets and 1.0 micrograms.kg-1.min-1 in mature swine) decreased RBF and increased renal resistance. Dopamine at equi-inotropic doses (10 micrograms.kg-1 min-1 in piglets and 20 micrograms.kg-1.min-1 in mature swine) increased RBF and decreased renal resistance only in mature swine. Infusions of dopamine at a low dose (5 micrograms.kg-1.min-1) also failed to increase RBF or decrease renal resistance in piglets. The results suggest that maturation of the mechanism of renal vasodilation by dopamine occurs later than that for vasoconstriction by norepinephrine.

Aging↗
PubMed1977

Constrictive pericarditis in familial Mediterranean fever.

Fibrosing peritonitis and constrictive pericarditis occurred in an 18-year-old patient who manifested the classic features of familial Mediterranean fever (FMF). Pericardial calcification had been present in chest X-rays taken when the patient was five years old. Intermittent intestinal obstruction and congestive heart failure were relieved by appropriate surgical intervention, but attacks of FMF subsided only after colchicine therapy. This is the first instance of nonuremic pericarditis in our experience with over 1,000 FMF patients. Critical analysis of the reported cases in which pericarditis was attributed to FMF strengthens our belief that the occurrence of pericarditis in a patient with FMF probably represents a fortuitous intercurrent disease.

Adolescent↗
PubMed1976

Effects of exposure to Finnish sauna.

Pathophysiological effects of exposure to Finnish sauna (80 to 90 C, 30 to 40% relative humidity) were investigated in 60 volunteers--33 men and 27 women aged between 18 and 63 years. The volunteers entered the sauna after a rest period of 20 min, and remained there for 20 min or until they suffered discomfort. Weight, height, rectal and skin temperatures, blood pressure, heart and respiratory rates and ECG were recorded 20 min prior to the sauna, during the sauna, and 20 min after leaving the sauna. Marked physiological changes appeared in the first few minutes in the sauna without any prodromal warning. At the 20th min the mean heart rate was 143 +/- 25 (SD) beats/min (greater than 160 beats/min in 32% of the subjects). Mean rectal temperature was 38.6 +/- 0.6 (SD) C (greater than 39 C in 22%): mean skin temperature was 40.4 +/- 1 (SD) C (greater than 40 C in 35%); mean systolic blood pressure was 130.5 +/- 26.6 (SD) mm Hg (greater than 160 mm Hg in 17%); and mean diastolic pressure was 66.6 +/- 15.9 (SD) mm Hg (greater than 50 mm Hg in 17%). The mean total sweat loss was 457 +/- 264 (SD) g. Three subjects experienced syncope, and one developed an anginal attack; ECG changes suggestive of coronary insufficiency were recorded. No decrease in blood pressure occurred in patients with preexisting high blood pressure. It is concluded that sauna bathing involves dangers to the bather's health, which may appear suddenly, without prodromal warning signs.

Adolescent↗
PubMedDate not supplied

The effect of pregnancy on renal function in amyloidosis of familial Mediterranean fever.

The effect of pregnancy on kidney function was studied in 29 pregnancies of 17 patients with familial Mediterranean fever (FMF) and amyloidosis. Pregnancy associated deterioration of renal function occurred in seven patients who had advanced renal disease at conception, marked by serum creatinine > or = 1.5 mg/dl or urine protein > or = 2 g/24 h. This finding suggests that the severity of renal disease at conception may predict the fate of kidney function during pregnancy and puerperium.

Adolescent↗