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Biomedical subjects

S C Walker

Publications and source records attributed to S C Walker.

41 records · Page 3Linked to original sources
PubMed1984

Hepatic arterial perfusion scintigraphy with Tc-99m-MAA. Use of a totally implanted drug delivery system.

Tc-99m-MAA hepatic arterial perfusion scintigraphy ( HAPS ) using a totally implanted drug delivery system was employed for hepatic arterial chemotherapy in 147 patients (335 studies). Complete perfusion of the involved liver was seen in 88% of patients initially [more so in those with normal hepatic vascular anatomy (93%) than those with vascular variants (79%)] and remained good on follow-up. In 67 consecutive patients (95 studies), arteriovenous shunting to the lung ranged from 0.4 to 32% (mean, 6.2% +/- 4.1 S.D.). Uptake at the tip of the catheter was increased in 20% of patients, but good perfusion was usually maintained. A significant decrease in hepatic and/or extrahepatic perfusion associated with a "hot spot" at the tip of the catheter indicated hepatic arterial thrombosis. Extrahepatic perfusion was seen in 14% of cases, usually in the distribution of the stomach, small bowel, and spleen. Significant symptoms of drug toxicity were seen in 70% of patients with extrahepatic perfusion, compared to 19% of those without it.

Adult↗
PubMed1984

Total contact casting in diabetic patients with neuropathic foot ulcerations.

This study investigated total contact casting in the treatment of diabetic foot ulcerations and factors affecting the rate of ulcer healing. Twenty-two diabetic patients with foot ulcerations were rated on the basis of age, weight, ulcer size, and ulcer grade. After treatment with total contact casting, 16 patients (72.7%) healed in an average of 38.3 days, 3 refused treatment, 1 developed a small tibial ulceration, and the remainder were discontinued due to excessive edema. A significant (p less than 0.01) t test for differences between means was calculated comparing ulcer duration prior to casting to healing rate during casting. All patient variables were intercorrelated, and significant (p less than 0.01) intercorrelations among patient variables were as follows: age with grade, 0.58; grade with healing time, 0.49; size with healing time, 0.50; age with ulcer size, 0.36; weight with ulcer size, 0.37; age with healing time, 0.32. A multiple correlation of 0.69 (p less than 0.01) was found for age, grade, size, and weight with healing time. Ulcer grade and size contributed most directly to the total multiple correlation; age contributed equally to size, grade, and healing time; and weight contributed primarily to ulcer size. These results suggest the following: 1) total contact casting is an extremely valuable method of treatment for diabetic foot ulcerations, and 2) when using this treatment technique associated factors (ulcer size, ulcer grade, patient age, patient weight) may be utilized to help predict patient healing.

Adult↗
PubMedDate not supplied

Return to work after burn injury.

The research literature suggests but does not test the hypothesis that differential factors determine when a patient will return to work after serious burn injury. In this study, factors influencing time before return to work after serious burn injury were investigated prospectively as part of a large burn research project. Sixty-five patients with burns who had returned to work were followed. Several variables were examined, including percent total body surface area burned, total percent of partial-thickness burn, total percent of full-thickness burn, duration of treatment, payment source for treatment, sex, race, type of burn, and age. The most significant predictor of time before return to work was percent total body surface area burned, followed by percent body surface area with full-thickness burns, percent body surface area with partial-thickness burns, and number of weeks of treatment, respectively. Sufficient data were available to develop a regression equation to specifically predict time before return to work. The data presented here are useful in informing patients, families, employers, and health-funding agencies as to the probable delay before return to work that can be expected after serious burn injury. In particular, predictability refinements are possible with the regression equation developed in this study.

Adolescent↗