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Biomedical subjects

S C Thompson

Publications and source records attributed to S C Thompson.

84 records · Page 5Linked to original sources
PubMed1980

The economics of dairy farming in Canada.

Government policies affecting the Canadian dairy industry represent a unique solution to a problem of surpluses which exists in most Western countries. This paper sketches an outline of dairy farming today before examining the trends and structural changes undergone by the industry over the Seventies. Milk yields have increased slightly and total numbers of dairy farmers have halved. After a decade of turmoil in international markets for dairy products, some stability is now returning and dairy farmers appear to be on the verge of a technological leap forward in dairying. By the end of the Eighties there could be no more than 13,500 commercial dairy farms supplying milk in Canada.Canada, along with other Western countries, produces more milk protein than it needs and different proposals for redressing this imbalance in the Eighties are appraised. One proposal advocates cutting back on domestic production and purchasing butter to make up the difference on the international market. A scheme based on recent British analysis proposes a swing towards Jersey milk production. Lastly the possibility of expanding market demand for products rich in milk protein is examined.

Animals↗
PubMed1976

Effect of age and sex on lung-colony-forming efficiency of injected mouse tumour cells.

The i.v. injection of a specified number of cells of either an Ehrlich ascites tumour (ELD) or spontaneous mouse mammary adenocarcinomas (MA) into C3H mice yielded a number of lung colonies which varied significantly with the age or sex of recipient mice. The yield was higher in mice of 71 weeks than in those of 15 weeks, except for MA cells injected into females, when the yield was higher in the younger mice. Sex did not influence very significantly the yield of colonies from ELD cells; in the case of MA cells the direction of sex differences depended on age. A difference in the effect of pre-immunization with age was not observed.

Adenocarcinoma↗
PubMed1974

The colony forming efficiency of single cells and cell aggregates from a spontaneous mouse mammary tumour using the lung colony assay.

Single cell suspensions of spontaneous C3H mammary tumours did not produce colonies in the lungs of syngeneic mice after intravenous injection whereas cell aggregates obtained from similar tumours did. The number of colonies formed after the injection of aggregates was related to aggregate size and was proportional to the number injected.Single cells grew in an intramuscular site and in vitro and it was also found that if spontaneous tumours were passaged in vivo a few times single cells would grow in the lung.

Animals↗
PubMed1974

Tumour colony growth in the irradiated mouse lung.

The effect of irradiation of recipient mouse lung on tumour colony growth after intravenous injection of C3H mammary adenocarcinoma cells or aggregates was tested in C3H male mice irradiated with 14 MeV electrons to the whole or half of the thorax. Injections were made 3 h, 48 h, 3½ months or 9½ months after irradiation.The number and size of colonies were increased in irradiated areas of the lung at 48 h and at 3½ months after doses of 2000 rad. However, 9½ months after irradiation lungs were found to be atrophied and fibrotic and enumeration of tumour colonies was found to be impossible. An increase in colony growth after 250 rad was seen only at 9½ months after irradiation.

Adenocarcinoma↗
PubMedDate not supplied

Intraventricular insulin suppresses the acoustic startle response in rats.

We and others have previously reported that the hormone insulin alters brain noradrenergic function at the synaptic and molecular levels. In the present study, we examined the in vivo effect of insulin (administered chronically via osmotic minipumps at a dose of 5 mU/day into the third cerebral ventricle) on the acoustic startle response. Rats receiving chronic intraventricular insulin had a significantly reduced startle response relative to vehicle-treated controls (i.e., 47 +/- 21% of baseline control startle response). Because our previous findings suggest that on an acute basis, insulin may enhance endogenous noradrenergic activity by inhibiting norepinephrine reuptake, we speculate here that the chronic effect of insulin is similar to that of the noradrenergic reuptake blocker, desipramine, which has been reported to decrease baseline startle performance.

Acoustic Stimulation↗
PubMedDate not supplied

Immunogenicity and reactogenicity of a combined hepatitis A-hepatitis B vaccine in adolescents.

OBJECTIVE: To evaluate the immunogenicity and reactogenicity of two lots of a combined hepatitis A-hepatitis B vaccine (HAV, HBV) in healthy 15 to 18 year olds. DESIGN: This was a double-blind, randomized clinical study. Vaccine was administered into the deltoid at 0, 1, and 6 months. Immunogenicity was assessed by anti-HAV and anti-HBs antibody levels at 2, 6, and 7 months after the first vaccine dose. Reactogenicity was assessed through use of 3-day diary cards following each vaccination, plus recording other unsolicited reactions. RESULTS: A total of 160 adolescents were vaccinated; 155 who were seronegative for hepatitis A and B at baseline and who completed the study were included in the immunogenicity analysis. The vaccine was well tolerated; most side effects were local, of low intensity and short duration. Good immunogenicity was determined by antibody titers. High rates of seropositivity (99.4%) were achieved after two doses against HAV, and after three doses for anti-HBs (seroprotection = 98.7%). CONCLUSIONS: This combination vaccine will be useful for immunizing selected high-risk groups in developed countries. In countries where endemicity is low for both diseases, targeting students prior to risk of acquisition would be a feasible preventive strategy.

Adolescent↗