Biomedical subjects

S C Small

Publications and source records attributed to S C Small.

9 recordsLinked to original sources

PubMed1995

Sweet taste (dysgeusia). The first symptom of hyponatremia in small cell carcinoma of the lung.

Three patients with small cell carcinoma of the lung presented with a persistent unpleasant sweet taste as their initial and only symptom. On further evaluation, they were found to have hyponatremia secondary to the syndrome of inappropriate secretion of antidiuretic hormone. In each case, resolution of the sweet taste paralleled an increase in serum sodium concentration after water restriction alone. Linkage of the sweet taste with a low serum sodium concentration strongly implicates hyponatremia--rather than tumor, antidiuretic factor, medications, or chemotherapy--as the central mechanism responsible for this previously unreported (to our knowledge) sentinel symptom of small cell carcinoma of the lung.

Carcinoma, Small Cell↗

PubMed1994

Money matters.

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Humans↗

PubMed1992

Stimulation frequency and force potentiation in the human adductor pollicis muscle.

The effect of stimulation frequency on twitch force potentiation was examined in the adductor pollicis muscle of ten normal subjects. The ulnar nerve was supramaximally stimulated at the wrist and isometric twitch force was measured from a 3-Hz train lasting 1 s. Test stimulation frequencies of 5, 10, 20, 25, 30, 40, 50 and 100 Hz were applied for 5 s each in random order (5 min apart) and the twitches (3 Hz) were applied immediately before and after (1 s) the test frequency and at intervals up to 5 min afterwards (10 s, and 1, 2 and 5 min). Poststimulation twitches were expressed as a percentage of the prestimulation twitch. Low frequency fatigue was not induced by the protocol since the 20:50 Hz ratio did not alter within each session. The degree of twitch potentiation was frequency dependent, with potentiation increasing up to 50 Hz [mean 173 (SD 16)%] but the effect was markedly less at 100 Hz [mean 133 (SD 25)%, P less than 0.01] for all subjects. The reduced potentiation at 100 Hz may have occurred due to high frequency fatigue produced by the 100-Hz test stimulation train. The optimal frequency of those examined in the experimental group was 50 Hz but this only produced maximal potentiation in six of the ten subjects and 100 Hz always produced less potentiation. These findings have implications for electrical stimulation of muscle in the clinical setting.

Adult↗

PubMed1991