Aggression as an adverse drug reaction.
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Aggression↗
Biomedical subjects
S C Shaw
Publications and source records attributed to S C Shaw.
Canine lymphomatoid granulomatosis: an immunophenotypic analysis of three cases.
Three dogs had a history of multiple progressive lesions affecting the skin, subcutis or skeletal muscles. The lesions developed over a period of several months, and each case demonstrated late cardiopulmonary complications. Post-mortem examination revealed multicentric, angio-destructive, lymphohistiocytic, proliferative lesions typical of the rare disorder lymphomatoid granulomatosis. Immunohistochemical examination demonstrated variable CD3 antigen expression by the atypical cell population in two of the three cases. This provides the first evidence that canine lymphomatoid granulomatosis may be a form of atypical T-cell lymphoma similar to the comparable disorder that occurs in man.
Animals↗
Von Wille-brand's disease in UK dobermanns: possible correlation of a polymorphic DNA marker with disease status.
Ninety-one dobermanns have been typed for a polymorphic microsatellite DNA marker situated within an intron of the von Willebrand factor gene and the alleles correlated with von Wille-brand's disease status. Two alleles were identified, one associated only with the normal gene and the other with both normal and disease genes.
Alleles↗
Vitamin K-dependent coagulopathy in a British Devon rex cat.
Deficiencies of the vitamin K-dependent coagulation factors were identified in a Devon rex cat which had bled after castration. Haemorrhage was controlled by plasma transfusion. Clotting times were normalised by oral administration of vitamin K. This report confirms the existence of this bleeding disorder in a Devon rex cat in the United Kingdom.
Administration, Oral↗
Lessons from pilot tests of computer self-help for agora/claustrophobia and panic.
Two pilot tests were made of computer-aided self-help for chronic agora/claustrophobia diagnosed by a psychiatrist. Test 1 was of 17 patients at the Institute of Psychiatry (IoP). They had no human clinical help, getting ideas only from the computer on how to do self-exposure therapy and set exposure goals week by week. Patients could attend for 12 sessions. Outcome data were inconsistent across ratings, not always matching clinical impression of progress. Of the 15 patients for whom outcome data were available, 6 improved markedly or moderately on clinical impression. Test 2 was of 6 patients in a rural general practice (GP) in Wales who were given help and support from a nonclinical administrator. Of the 4 Welsh patients with follow-up data, 3 improved markedly or moderately. The test results suggest desirable changes. Patients first need to do practice ratings before rating on the computer and to check computer ratings. Some rating instructions need to be clarified. Most importantly, synergism comes from giving patients access to brief human help if they encounter problems when using computer-aided self-help.
Adult↗