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Biomedical subjects

S C Sharma

Publications and source records attributed to S C Sharma.

At least 289 records · Page 16Linked to original sources
PubMed1981

Platelet adhesiveness, plasma fibrinogen, and fibrinolytic activity in juvenile-onset and maturity-onset diabetes mellitus.

The nature of vascular disease and its complications are different in juvenile-onset (JOD) and maturity-onset (MOD) diabetes mellitus. In order to explore the disturbances in the coagulation-fibrinolytic system, platelet adhesiveness, plasma fibrinogen, and euglobulin lysis time were estimated in 26 cases of MOD. Two groups of age- and sex-matched controls were also studied. Platelet adhesiveness and plasma fibrinogen were essentially normal while euglobulin lysis time was significantly decreased in the JOD group. The MOD group, on the other hand, showed a reversed pattern in the form of enhanced platelet adhesiveness and plasma fibrinogen and no compensatory increase in fibrinolysis.

Adolescent↗
PubMed1981

Streptococcal pharyngitis--rapid diagnosis by Gram stain.

Group A beta-haemolytic streptococci were isolated from 51 (9.8%) of 519 patients with pharyngitis. Throat culture results showed the mean sensitivity, specificity and predictive value of a positive Gram-stained smear of pharyngeal secretions as 70%, 89% and 69%. The data suggest that Gram staining of a smear directly from the swab is as accurate as and more speedy than a culture from the pharyngeal secretion for diagnosis of streptococcal pharyngitis.

Adolescent↗
PubMed1981

Leprosy and female reproductive organs.

Thirty-five adult female patients with bacillary positive leprosy were studied to determine its effect on menarche, menstrual cycle, fertility, and menopause. Endometrial biopsies studied in 26 patients showed no evidence of leprosy bacilli granuloma or tubercle bacilli on culture. Menstrual blood examined in six patients with bacillemia did not reveal leprosy bacilli. Products of conception examined from two patients were negative for granulomata or leprosy bacilli. Leprosy was found to have no direct effect on menarche, menstruation, fertility, and menopause.

Endometrium↗
PubMed1981

Levels of total ascorbic acid and histamine in the blood of women during the 3rd trimester of normal pregnancy.

Levels of total ascorbic acid and histamine in the peripheral venous blood of women during the third trimester of normal pregnancy have been estimated. The results suggest that ascorbic acid acts as a modulator to control the synthesis and/or release of histamine in the body. Low levels of ascorbic acid may be essential to stimulate the synthesis and/or release of histamine while in high concentrations it may function to inhibit the release and/or to enhance the breakdown of excessive quantities of histamine in the body. Substantial evidence is now available that histamine, perhaps its nascent variety, is essential for growth and repair processes in the body. It is possible that ascorbic acid in low concentrations acts to stimulate this variety of histamine while its high concentrations act to control the levels of histamine released from storage sites which contain preformed histamine.

Adolescent↗
PubMed1980

Retinal projection to a rotated tectal reimplant following long-term tectal denervation in adult goldfish.

Following optic nerve crush, the precise termination sites of regenerating goldfish optic axons may be influenced by the presence or absence of degenerating axonal debris from the previous projection. We investigated wheter tectal polarity reversal can be induced in the absence of axonal debris. The right optic tectum was denervated by contralateral eye removal. One year later, when no debris was present, a piece of the right tectum was rotated and innervation by the right eye was induced by removal of the left tectum. The new ipsilateral projection to the rotated region was correspondingly rotated. It is concluded that retention of tectal polarity is not dependent upon degenerating axonal debris.

Animals↗
PubMed1980

Platelet adhesiveness in permanent residents of high altitude.

Platelet adhesiveness (PA) has been studied in 43 permanent residents of high altitude (highlanders) and in an equal number of age matched low landers for comparison. The importance of our findings in the light of our earlier observations in young low landers developing ischaemic cerebral stroke at high altitude and the development of ill effects of high altitude induction in fresh unacclimatised inductees is discussed.

Adult↗
PubMed1980

Platelet count on acute induction to high altitude.

Platelet counts in 50 normal healthy volunteers were performed at sea level and then serially on rapid induction to 3658 m by air. Subjects were divided into "symptomatic# and "asymptomatic# groups depending on their score on the symptoms score chart. All were brought back to sea level and study repeated. Platelet count in the symptomatic group showed a falling trend while in the asymptomatics a gradual rise was noted.

Adult↗
PubMed1980

Histogenesis of the goldfish retina.

The order of production of retinal cells was studied in embryos of the goldfish, Carassius auratus, using 3H-thymidine autoradiography. Cell division ceases first in the neuroepithelium at the fundus of the eye between embryonic stages 19 and 20 and gradually becomes restricted to the retinal margin by stage 24. In the fundus the cells whose nuclei will reside in the inner layer of the retina stop dividing earlier than the cells whose nuclei will reside in the outer retinal layers. Thus the ganglion cells in the fundus of the retina are produced first and the receptors and horizontal cells last.

Animals↗
PubMed1980

Leucocyte alkaline phosphatase in neonatal infections.

The leucocyte alkaline phosphatase (LAP) score was estimated in healthy and infected neonates. A leucocyte band count was also done simultaneously. The infected group showed a significant (P < 0.001) decrease in the LAP score and a significant (P < 0.001) increase in the band count. These findings are discussed.

Alkaline Phosphatase↗
PubMed1980

Platelet count in temporary residents of high altitude.

Platelet count was estimated in 65 lowlanders temporarily staying at altitudes above 3,000 m. They were divided in subgroups according to the length of their continuous stay. For comparison, 51 highlanders who were born and reared at high altitude and 48 lowlanders who had never been to an altitude of more than 1,000 m were also studied. Gradually rising counts becoming highly significant (P < 0.001) as compared to the lowlanders after 31 days of stay and stabilizing close to the values in highlanders after 181 days were noted. The significance of these findings in the light of existing knowledge is discussed.

Adult↗
PubMed1980

The celluar interaction of ascorbic acid with histamine, cyclic nucleotides and prostaglandins in the immediate hypersensitivity reaction.

The role of ascorbic acid is reviewed in relation to the mechanism of release of chemical mediators in the immediate hypersensitivity reaction. In the initiation, and second, stages of the reaction, the property of ascorbic acid to chelate with calcium appears to play an importnat role in the ultimate release of the mediators. Furthermore, ascorbic acid may also control release of histamine and prostaglandins of the E and F types through its action on cyclic nucleotides and phosphodiesterase. In allergic inflammatory disease, leucocyte and tissue ascorbic acid levels are reduced. This may be due to the increased utilisation by cells involved in the antigen-antibody reaction. The suggestion that the balance between cyclic nucleotides is the main controlling mechanism for the release of chemical mediators during the reaction is inadequate to account for the essential role of other agents including ascorbic acid in the mechanism.

Animals↗