THE PROGNOSTIC VALUE OF BLOOD VESSEL INVASION AND LYMPHOCYTIC INFILTRATES IN BREAST CARCINOMA.
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Biomedical subjects
Publications and source records attributed to S C SOMMERS.
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Cytoplasmic inclusions in the special pulmonary alveolar cells of adult, newborn, and fetal rats were investigated by electron microscopy and histochemistry, and lung extracts were analyzed for surface-tension activity. The inclusions were positive in the periodic acid-Schiff test after digestion with diastase and were not stained with toluidine blue; they formed myelin figures and possessed alkaline phosphatase activity. Both the typical surface tension activity and the inclusions developed 2 days before birth. These properties differentiated the inclusions from mitochondria.
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The findings at autopsy in 99 cases of perinatal deaths in a ten-year period and on pathologic examination of the accompanying placentas in 39 cases were analyzed clinicopathologically. Also reviewed were the pathologic diagnoses of 225 placentas that were examined for causes other than neonatal death. Cardiovascular and pulmonary problems, particularly hyaline membrane disease, atelectasis and cardiac anomalies were most common. Asphyxia, heart failure and premature placental separation were the most frequent causes of death. In slightly more than half of the cases a reasonable final diagnosis was established by autopsy, and if the placenta was examined, nearly two-thirds could be properly classified. In the remaining 37 per cent, as previously reported in larger series, neither the autopsy nor placental examinations disclosed a satisfactory explanation of the perinatal death.
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