Biomedical subjects
S C Naiman
Publications and source records attributed to S C Naiman.
Prospective randomized trial of piperacillin monotherapy versus carboxypenicillin-aminoglycoside combination regimens in the empirical treatment of serious bacterial infections.
Piperacillin as a single agent was compared in a prospective randomized trial with carboxypenicillin-aminoglycoside combinations in empirical therapy of serious bacterial infections. The difference in the clinical response rates with piperacillin (77% of 26 infection episodes) and combination therapy (75% of 24 infection episodes) were not statistically significant. Fewer adverse effects occurred in the piperacillin-treated group (42%) than in the combination-treated group (71%) (P = 0.0399 by Fisher's exact test), although neither nephrotoxicity nor hypokalemia alone was significantly less frequent in patients receiving piperacillin. However, the emergence of resistant organisms during therapy was more frequent among patients receiving piperacillin alone (42% of patients) than among patients receiving combination therapy (17% of patients) (P = 0.465 by Fisher's exact test). Moreover, emergence of resistance accounted for 5 of 9 patients with treatment failure, superinfection, or both when piperacillin was used as a single agent, compared with 2 of 10 similar patients in the combination group (P = 0.1299 by Fisher's exact test). The use of piperacillin as a single agent in the treatment of serious bacterial infections is not advocated, and the addition of an aminoglycoside to prevent emergence of resistance during empirical therapy of such infections is strongly recommended.
Ultrasonography and computed tomography of hepatic candidiasis in immunosuppressed patients.
The ultrasonic appearance of Candida infection in the livers of immunosuppressed patients is quite characteristic. Cystic, target-like lesions were found in three patients receiving chemotherapy for myeloproliferative diseases. The computed tomographic appearance is less characteristic. A possible explanation for the appearance of these lesions is presented.
Bone scintigraphy in massive disseminated bone necrosis.
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Hageman factor deficiency and oral contraceptives.
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Intramural hematoma of the gastric cardia.
A case of intramural hematoma of the gastric cardia occurring in a young woman with S.L.E. and on warfarin is presented and discussed. This unusual case illustrates the importance of careful evaluation of radiological mass lesions of the cardia.
In vitro growth of basophils containing the Philadelphia chromosome in the acute phase of chronic myelogenous leukaemia.
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Letter: Platelet function and G.-6-P.D. deficiency.
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Neutrophil dysfunction, chronic granulomatous disease, and non-spherocytic haemolytic anaemia caused by complete deficiency of glucose-6-phosphate dehydrogenase.
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Fibrin thrombi in the pulmonary microcirculation of dogs with gram-negative bacteremia.
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Lymphocyte transformation by phytohemagglutinin: IV. In acute upper respiratory infections.
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Lymphocyte transformation by phytohemagglutinin. II. In the tuberculous patient.
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Acquired hemolytic anemia due to "auto"-anti-A or "auto"-anti-B induced by group O homograft in renal transplant recipients.
Three patients developed severe but self-limited hemolytic anemia within 2 weeks of renal transplantation. All three had received kidneys from cadaver donors who were blood group O. Two of the recipients were blood group B while the third was blood group A. There was no pretransplant preparation of the donors or the recipients. Preoperative crossmatch and antibody screen were negative; however, subsequent to the hemolytic episodes, group-specific blood was incompatible and the patients were transfused with group O crossmatch-compatible blood. Blood bank serological tests showed a positive direct antiglobulin test (DAT), and anti-A and anti-B were eluted from group A and B patients, respectively. There was no evidence of hemolysis despite the positive DAT at 37 days following transplantation in two of the three patients who were maintained on cyclosporine immunosuppression. Retrospective analysis of renal transplant records showed that these "autoantibodies" appeared in three of the four renal transplant recipients who were on an immunosuppressive regimen of cyclosporine , with or without prednisone, but not in the 21 recipients who received radiotherapy to the donor kidney in addition to cyclosporine or azathioprine (p = less than 0.001). The possible pathogenetic mechanism for "autoantibody" formation by donor kidney and the role of immunosuppressive agents are discussed.
The response of an acquired Factor V inhibitor to activated Factor IX concentrate.
A 91-year-old man developed a severe bleeding diathesis postoperatively. Laboratory studies showed an inhibitor to factor V which was identified as IgG. The patient failed to respond to fresh-frozen plasma and platelet transfusions, but demonstrated both clinical and laboratory improvement after transfusion with an activated prothrombin complex concentrate (Autoplex). Patients with refractory inhibitors to factors VIII or IX have been managed successfully with this concentrate; however, this case demonstrates that is also may be of value in managing patients with refractory inhibitors to factor V.