Isotretinoin and skin fragility.
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Acne Vulgaris↗
Biomedical subjects
S C Holmes
Publications and source records attributed to S C Holmes.
Primary testicular disease presenting as azoospermia or oligozoospermia in an infertility clinic.
A group of 173 patients who made up 23% of a population of patients attending a male infertility clinic with primary testicular disease were examined; 63 patients (36%) were azoospermic and 110 (64%) were oligozoospermic. Their aetiology and clinical features are described, together with the endocrine findings, white blood cell karyotypes and, where available, the histology seen on a testicular biopsy. The relationship of these lesions with the presence or absence of a varicocele is discussed.
Adult↗
Novel variants of human papillomavirus type 2 in warts from immunocompromised individuals.
Twenty cutaneous warts from I8 renal transplant recipients (RTR) and a single wart sample from a patient suffering from Hodgkin's disease were screened for the presence of human papillomavirus (HPV) sequences by Southern blot analysis. Thirteen samples were shown to contain HPV DNA sequences, one was identified as HPV-3, two as HPV-4, six as HPV-2 and four were unidentifiable by restriction digest analysis. HPV-3 was identified in the wart sample from the patient suffering from Hodgkin's disease. In the six samples in which HPV-2 was found, the viral genome showed polymorphism for the PvuII and PstI sites. Two PvuII patterns and one PstI pattern are novel.
Blotting, Southern↗
Focal dermal hypoplasia syndrome in the neonate.
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Ectodermal Dysplasia↗
Nuclear envelope glycoprotein with poly(A) polymerase activity of rat liver: isolation, characterization, and immunohistochemical localization.
A protein with poly(A) polymerase activity has been identified and isolated from hepatic nuclear envelopes of rats to near homogeneity. The ability of the enzyme to bind to concanavalin A-agarose and to be eluted from the column with methyl alpha-D-mannopyranoside (0.2 M) as well as the inhibitory effects of alpha-mannosidase suggested that it was a glycoprotein. Poly(A) polymerase has an absolute requirement for a divalent cation, ATP, and an oligonucleotide primer. The enzyme activity with Mn2+ was about 20-fold higher than that with Mg2+. Several known inhibitors adversely affected poly(A) polymerase activity. The enzyme has a molecular weight of 64,000 when analyzed by polyacrylamide gel electrophoresis under denaturing conditions and has a sedimentation coefficient of 4.5 S. Immunohistochemical studies using polyclonal antibodies raised against the purified enzyme revealed that the antigen was localized in the nuclear membranes.
Adenosine Triphosphate↗
Poly(A) polymerase activity in murine serum. Elevation in animals with proliferative changes.
Sera of normal rats contain polynucleotide adenylyltransferase [poly(A) polymerase] activity. The enzymatic activity has been optimized with regard to primer concentration, ion requirements, kinetics, and protein. Results based on inclusion of inhibitors in the assay system show that the enzyme is poly(A) polymerase. High levels of the enzymatic activity were prevalent in sera of (a) BUF/SimfBR rats bearing sc transplanted hepatomas; (b) Sprague-Dawley rats with hepatoma cells grown in ascites; (c) partially hepatectomized Sprague-Dawley rats; and (d) MRL/lpr mice, which are in a massive lymphoproliferative autoimmune state.
Animals↗
Aetiological factors in the production of obstructive azoospermia.
From a group of 749 infertile men, 102 (13.6%) were found to have obstructive azoospermia. An attempt is made to ascribe an aetiology to these obstructive lesions. In more than half of these patients, no cause for their obstructive lesion could be elicited. Only five gave a past history of gonorrhoea, and genital tract infection related to only eight patients. The disorder now most frequently associated with obstructive azoospermia is chronic respiratory disease. It is suggested that the aetiology of obstructive azoospermia has changed in recent years.
Constriction, Pathologic↗
Incomplete obstruction of the male genital tract: a cause of oligozoospermia.
Of 71 patients with obstructive azoospermia, 8 gave a history and/or had documentary evidence of oligozoospermia in the past and 2 gave a history of paternity. Thus a period of oligozoospermia preceded their azoospermia. "Partial obstruction" is therefore postulated as a cause of oligozoospermia.
Biopsy↗
Clearance of UVB-induced erythema in patients with non-melanoma skin cancer.
We have examined the clearance of UVB-induced erythema in 10 non-melanoma skin cancer (NMSC) patients, comparing their responses to a control group. All participants were followed to resolution of erythema, as measured by a chromameter. The resultant response pattern was modelled in three phases, with comparison of the rates of decay in erythema carried out. Analysis of the rapid decay phase demonstrated a significantly slower rate of resolution of erythema in the NMSC group, compared with the controls. Further elucidation of the molecular and genetic mechanisms controlling this response may improve our understanding of UV-induced carcinogenesis.
Basal Cell Carcinoma↗