Laparoscopic diagnosis of subcapsular hepatic hemorrhage in pre-eclamptic liver disease.
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Adult↗
Biomedical subjects
S C Gordon
Publications and source records attributed to S C Gordon.
Mumps arthritis: a review of the literature.
Arthropathy is an unusual but significant complication of mumps viral infection. Predominantly affecting young adult males, large and small joint involvement occur before, after, or in the absence of parotitis. Fever, leukocytosis, and elevated erythrocyte sedimentation rate accompany an occasionally protracted course. A high incidence of associated visceral manifestations occurs among patients with mumps arthritis. A review of the pathogenesis of these other complications suggests direct viral invasion as the most likely pathogenesis of mumps arthritis. The possibility of mumps virus arthritis should be considered in patients with acute-onset, obscure, or febrile seronegative arthritis.
Adolescent↗
Extrahepatic manifestations of hepatitis C.
Shortly after the discovery of the hepatitis C virus, it was realized that this infectious agent caused more than just liver disease. A remarkable array of extrahepatic manifestations of hepatitis C has now been described. Many of these associated syndromes implicate the hepatitis C virus as a mediator of autoimmunity or of immune complex formation. These disorders include mixed essential cryoglobulinemia, autoimmune hepatitis, glomerulonephritis, thyroiditis, and possibly Sjogren's syndrome. The hepatitis C virus has also been strongly linked to two skin disorders: prophyria cutanea tarda and lichen planus. Other possible hepatitis-C-associated diseases described in the literature include idiopathic pulmonary fibrosis, IgA deficiency. Mooren's corneal ulcers, Behcet's syndrome, polyarthritis, Guillain-Barre' syndrome, idiopathic thrombocytopenic purpura, and others. A number of these reported diseases have either responded to or been cured by a therapeutic course of alpha interferon. This report discusses the reported extrahepatic manifestations of hepatitis C as of mid-1995.
Arthritis, Infectious↗
Autoantibodies to specific enzymes: a review.
There are two categories of autoantibodies to specific enzymes: immunoglobulin-complexed enzymes and circulating autoantibodies directed to enzymes in tissue or tissues. Immunoglobulin-complexed enzymes may result in elevated serum enzyme activity. They are found more frequently in elderly patients and have limited clinical significance. Immunoglobulin association with the enzyme must be demonstrated to distinguish this macroenzyme from other high molecular weight enzyme complexes. Autoantibodies to specific enzymes or regulators of enzyme activity do possess specific disease associations. The titers or presence of these autoantibodies may predict morbidity or response to therapy. These autoantibodies may be detected by Western blotting, enzyme-linked immunosorbent assays, tissue immunofluorescence, radioimmunoassay, immunoprecipitation flow cytometry or inhibition of enzyme activity. For example, anti-pyruvate dehydrogenase inhibits the activity of purified enzyme, but not relatively intact mitochondrial preparations. Most evidence suggests that the production of autoantibodies to specific enzymes represents an epiphenomenon secondary to tissue damage rather than a primary event in the pathogenetic pathway.
Alkaline Phosphatase↗