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Biomedical subjects

S C Brown

Publications and source records attributed to S C Brown.

At least 145 records · Page 8Linked to original sources
PubMed1977

Biomechanics of water-pumping by Chaetopterus variopedatus Renier: Kinetics and hydrodynamics.

1. The activities of the three water-pumping segments of Chaetopterus variopedatus are correlated in detail with the fluctuations in water flow through the tube-house. 2. The qualitative performance and design features of the worm's pumping mechanism are compared to those of mechanical reciprocating pumps. 3. Quantitative data on volume flow rate, stroke rate, discharge pressure, and oxygen consumption yield estimates of power output (1.5 X 10(-5) Joules/sec) and aerobic efficiency (0.5%). 4. In its natural habitat, Chaetopterus does no lifting work, but rather functions solely as a transfer pump. 5. Calculations show that, of the work accomplished by Chaetopterus during pumping, 95% is devoted to overcoming inertial resistance.

Animals↗
PubMed1974

President's Page.

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Journal Article↗
PubMed1974

President's Page.

Explore the source record for details and available documents.

Journal Article↗
PubMed1973

President's Page.

Explore the source record for details and available documents.

Journal Article↗
PubMedDate not supplied

Dystrophin and utrophin: genetic analyses of their role in skeletal muscle.

Since the identification of dystrophin as the causitive factor in Duchenne muscular dystrophy, there has been substantial progress in understanding the functions and interactions of this protein. Dystrophin has been shown to interact with a group of peripheral- and trans-membrane proteins known as the dystrophin-associated protein complex (DAPC) and mutations in some of the members of this complex have been shown to account for other forms of muscular dystrophy. This review summarizes the experiments using transgenic and knockout mouse models that have defined the roles of dystrophin, and the dystrophin-related protein utrophin at the skeletal muscle membrane and at the neuromuscular junction. These studies are presented in the context of other known interactions at the muscle membrane. Studies of the dystrophin-deficient mdx mouse have lead to a greater understanding of the human disease. Knockouts and transgenics of utrophin have shown this protein to be sufficient to functionally compensate for dystrophin. Dystrophin transgenic mice combined with the mdx mouse have been used to study the function of specific domains of the dystrophin protein. Together these animal models have led to a delineation of protein functions and localization patterns that will be useful for the generation of potential therapies for DMD.

Animals↗
PubMedDate not supplied

Enhancing self-esteem among cardiac patients.

This study examined the development, implementation, and evaluation of a module to enhance self-esteem among patients in an outpatient cardiac clinic. Eighty percent of the subjects reported that activities such as exercise and social functions helped them feel better about themselves. This data supported the use of spirituality, interpersonal relationships, self-care activities, and self-preservation concepts to enhance self-esteem in cardiac patients.

Heart Diseases↗
PubMedDate not supplied

Balloon angioplasty of native coarctation of the aorta in a local group of children: acute results and midterm angiographic re-assessment.

OBJECTIVE: Balloon angioplasty of native coarctation of the aorta is gaining acceptance as an alternative to surgery in children. The aim of this study was to assess the acute and midterm effectiveness and safety of the procedure. METHODS: During a 3-year period, nine patients with native coarctation underwent balloon angioplasty at a median age of 2.9 years (range: 4 mo - 12 y) and median weight of 11 kg (range: 3.1 - 51 kg). Balloon diameter selected was at least twice the diameter of the narrowed segment, but never more than the diameter of the aorta at diaphragmatic level. RESULTS: There was a significant improvement in the mean systolic gradient across the coarctation from 36 +/- 13mm Hg to 4 +/- 4 mm Hg (p < 0.001), and in the mean diameter of the narrowed segment from 4 +/- 1.3 mm to 7.2 +/- 2.7 mm (p < 0.001). There was no immediate mortality or complication. Follow-up catheterisation was done in eight patients, a mean of 2.7 years (range: 0.8 - 4 y) after the initial procedure. No evidence of restenosis was found, but one patient developed an aneurysm that was surgically resected. CONCLUSION: Balloon angioplasty is effective and safe for the treatment of native coarctation in children. Radiographic follow-up is advisable in the midterm. Balloon angioplasty offers an alternative to surgery in the treatment of selected children older than 3 months with native coarctation of the aorta.

Angiography↗