On the physical and intellectual development of black children with and without sickle cell trait.
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Black or African American↗
Biomedical subjects
S C Bernstein
Publications and source records attributed to S C Bernstein.
The demonstration of asymmetric hemoglobin hybrids by polyacrylamide electrophoresis.
A simpler, more economical technique than previously reported, that of conventional polyacrylamide gel electrophoresis alone, is described for the detection of asymmetric hemoglobin hybrids of the forms alphaXalphaYbeta2 and alpha2betaXbetaY when bloods from individuals with alpha and beta chain variants were examined. The presence of alpha chain variant hybrids, never before reported, is further evidence that hybrid formation is a more widespread phenomenon than has previously been thought of. Hybrids were found in artificial mixtures of hemoglobins and more importantly, are also reported here for the first time in bloods of individuals heterozygous for hemoglobin variants. These hybrid tetramers were as stable as the parent hemoglobins when examined under anaerobic conditions. The involvement of HbF in the formation of hybrids of the type alpha2betagamma is reported, and an analysis of the possible role of these as well as alpha2betaAbetaS hybrids in the sickling process is presented.
Binding Sites↗
Still more genetic variability in natural populations.
Heat-denaturation studies of xanthine dehydrogenase have revealed many more additional alleles at the locus controlling this enzyme than are revealed by electrophoretic studies. In natural populations of species in the virilis group of the genus Drosophila, heat-denaturation studies of flies from the same locality revealed 1.74 times as many alleles as did electrophoretic studies. Similarly, studies of several species over their geographic range also revealed 1.74 times as many alleles. In addition, for the nine species studied, electrophoretic analysis had revealed only 11 alleles within the group, whereas heat-denaturation studies revealed a total of 32 alleles. These findings are discussed in the light of the continuing controversy over Darwinian and non-Darwinian theories of evolution.
Aldehyde Oxidoreductases↗
A study of the relationship of structure and activity of antimycin A in the induction of carotenoid synthesis in Mycobacterium marinum.
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Acetates↗