A case in favour of Poncet's disease.
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Adult↗
Biomedical subjects
S C Allen
Publications and source records attributed to S C Allen.
Bleomycin therapy and anaesthesia. The possible hazards of oxygen administration to patients after treatment with bleomycin.
Bleomycin is a cytotoxic drug used in the treatment of teratoma of the testis. This drug appears to sensitize the lungs so that acute lung damage occurs with concentrations of oxygen normally considered free from toxic effects. Two anaesthetics administered to the same patient undergoing thoracotomy are reported. No postoperative lung damage was produced on either occasion.
Adult↗
A previous history of acute intermittent porphyria as a complication of obstetric anaesthesia.
The administration of general anaesthesia for Caesarean section is described in a patient with an established biochemical diagnosis of acute intermittent porphyria. The technique used did not precipitate an acute exacerbation of the disease. Drugs associated with obstetric care are considered in the context of their use in porphyria.
Acute Disease↗
The red cell osmometer. A useful inaccuracy in measurement of mean corpuscular volume in hyperosmolar states.
The Coulter S Counter gives a value for mean corpuscular volume which does not necessarily reflect red cell size in vivo. This phenomenon may be used in early diagnosis and hence prevention of the 'hyperosmolar syndrome'.
Erythrocyte Indices↗
Letter: Problems with naloxone.
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Humans↗
Aerosol bronchodilator administration in ventilator circuits.
A device is described enabling bronchodilator drugs in aerosol form to be added to the inspired gas of ventilated patients using standard metered-dose containers.
Aerosols↗
Falls on integrated medical wards.
BACKGROUND: An effective approach to fall prevention should involve an assessment of environmental as well as patient-related characteristics. OBJECTIVE: To study the effect of age and ward design on fall characteristics among medical inpatients. METHODS: In a prospective open observational study over 1 year, we studied falls on three medical wards. Wards A and B are nuclear designed, and C is longitudinal. RESULTS: We recorded 199 falls involving 167 fallers. Fifty-four (27.1%) involved patients under 65 years. Most falls were intrinsic (60.8%) and involved elderly male patients (male/female ratio 97/48 vs. 24/30; p = 0.009). We identified no age differences in relation to location, activity, preceding fall, classification, time, consequences, and intervention required. On ward C, most falls occurred in the bed areas (bays and cubicles), but on wards A and B a higher proportion occurred in bathroom, corridor, and dayroom (C vs. A/B 87.9 vs. 73.7/62.0%; p = 0.04/p = 0.004). On ward C, activities of daily living around the bed significantly preceded falls (C vs. A/B 44.6 vs. 25.9/24.1%; p = 0.03/p = 0.01). Most falls were unwitnessed (C vs. A/B 10 vs. 21/20; p = 0.002/p = 0.0009). CONCLUSIONS: Intrinsic falls are the commonest; however, differences exist in fall demographics between wards, and this must be recognized to enhance the effectiveness of fall prevention programmes.
Accidental Falls↗
The relationship between breathlessness and ventilation during steady-state exercise.
In clinical studies on breathlessness, the relationship between breathlessness and ventilation is a convenient way of summarizing the responses of single subjects or groups of subjects. This relationship is usually based on measurements during progressive exercise. The objective of this study was to determine whether the relationship was maintained in different conditions or whether breathlessness could alter independently of ventilation. Six healthy subjects undertook progressive exercise so that the relationship of breathlessness to ventilation could be described; the reproducibility was established. The same subjects also undertook exercise at two constant workloads. After 4 min, stable values of ventilation were achieved but the breathlessness scores continued to increase (p less than 0.05). These findings show that the relationship between breathlessness and ventilation may be disturbed without external intervention, and this provides further evidence that breathlessness is not simply a sensing of the ventilation achieved.
Adult↗
The effect of bronchodilator drugs on breath-holding capability in asthma.
A method of assessing the relationship between maximum voluntary breath-holding time (BHT) and the partial pressure of end-tidal carbon dioxide (PETCO2) during hyperoxic carbon dioxide rebreathing is described. The resulting index is referred to as the breath-holding capability (BHC). BHC and the maximum rate of early inspiratory pressure fall at the mouth while breathing oxygen at rest (RHdP/dtmax) were measured in normal and asthmatic subjects before and after treatment with nebulized solutions of salbutamol and ipratropium bromide. BHC was low in asthmatics when their airflow resistance was high and rose when the airflow resistance fell as the result of treatment; RHdp/dtmax was high in the asthmatics before treatment and fell after bronchodilator drugs were administered. The fall in respiratory drive which followed bronchodilatation in the asthmatic subjects cannot be solely explained in terms of the resulting fall in viscous and elastic work of breathing. Vagal afferent signals arising in the airways might play a part in modifying respiratory drive in such circumstances.
Adult↗
The effect of longterm alcohol exposure on liver choline dehydrogenase activity.
Rats were exposed to an ethanol-containing drinking mixture for 54, 84 and 105 days. It was shown that a progressive increase in liver choline dehydrogenase activity occurred which became statistically significant at 105 days. This may be the mechanism by which ethanol increases choline requirement in mammals. Studies of this type might further our understanding of alcohol-related liver disease, and are particularly pertinent in countries such as Zambia in which alcohol consumption is high and dietary choline intake is likely to be low.
Alcohol Oxidoreductases↗