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S Burtey

Publications and source records attributed to S Burtey.

12 recordsLinked to original sources
PubMed2006

Transcriptome analysis of a rat PKD model: Importance of genes involved in extracellular matrix metabolism.

Transcriptome analysis of a rat polycystic kidney disease (PKD) model: importance of genes involved in extracellular matrix metabolism. PKD is a common genetic cause of chronic renal failure, and is characterized by the accumulation of fluid-filled cysts in the kidneys and other organs. Abnormalities in the expression of selected genes thought to be involved in cystogenesis have been described, but no systematic analysis of the global transcriptomal pattern has been reported. With this aim, a rat oligomicroarray was used to identify variations in gene expression in Han:Sprague-Dawley Cy/Cy rats, an animal model presenting a severe PKD phenotype. Some upregulated genes were validated using real-time polymerase chain reaction in Cy/Cy and Cy/+ rats. Among the 350 genes identified as being upregulated, we found about 30 genes involved in extracellular matrix metabolism. These genes encoded proteins or peptides that could be implicated into two different biological processes: molecules involved in fibrosis and proteins involved in adhesion to the extracellular matrix. In heterozygotes, some genes (glypican 3, fibronectin 1) were already upregulated in early stages of the disease. We conclude that differential regulation of genes linked to extracellular matrix metabolism may be one of the first events leading to tubule enlargement and subsequent cyst formation in PKD.

Animals↗
PubMed2005

Cloning and expression of the amphibian homologue of the human PKD1 gene.

PKD1 is the gene responsible for autosomal dominant polycystic kidney disease (ADPKD) type 1 in humans. The PKD1 gene product is likely to be a calcium channel regulator. In this paper, we describe the isolation and characterization of the Xenopus homologue of the human PKD1 gene. We isolated and cloned genomic fragments corresponding to the amphibian homologue of PKD1 from a BAC library, and after sequencing the clones, we designed primers for the amplification of the transcript and sequenced 10 kb of ORF. The sequence of the putative protein clearly demonstrated that this gene is the homologue of human PKD1. Analysis of the tissue expression patterns of xPKD1 demonstrated a high level of expression in the kidney. A similar analysis in developing embryos and in an in vitro nephrogenic system suggests that xPKD1 is associated with, and probably involved in, the development of the amphibian pronephros.

Amphibian Proteins↗
PubMed2000

Ancestrally-duplicated paraHOX gene clusters in humans.

A paraHox gene cluster has been described recently in Amphioxus. We show here using bioinformatics and cytogenetics that, as the probable result of the duplication of an ancestral paraHox gene cluster, human paraHOX genes are located in four paralogous regions of the genome, on chromosomes 4, 5, 13 and X. By analogy with the four HOX gene clusters, we propose to designate the four paraHOX gene clusters as paraHOX-A to D clusters. We also propose a scenario for the evolution of HOX and paraHOX genes. Several chromosomal translocation breakpoints of hemopathies are located in the paralogous regions that contain the paraHOX genes. Two of the paraHOX genes are involved in these rearrangements.

Amino Acid Sequence↗
PubMed1999

Glomerulonephritis.

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Glomerulonephritis↗
PubMed1997

[Cycloid psychoses].

Cycloid psychoses constitute an original classification originally proposed by Leonhard and comprising clinical pictures intermediate between schizophrenic psychoses and bipolar disorders. The exact situation of these disorders in psychiatric classifications has been the subject of debate, and their existence is still questioned. Only schizo-affective psychoses have been accepted as autonomous. Treatment of cycloid psychoses most often consists of neuroleptics but also mood regulators, particularly those having anti-epileptic effects Lastly, prognosis of these disorders usually is not as poor as that of schizophrenia and is marked by a cycloid course, with symptom-free periods between episodes.

Humans↗
PubMed1997

[Tubular necrosis after non-steroidal anti-inflammatory agents and acute alcoholic intoxication].

Acute nephrotoxicity due to nonsteroidal anti-inflammatory drugs is usually observed in clinical situations in which renal perfusion is compromised as in volume contraction. We report a case of a 20 year-old woman who suffered from acute tubular necrosis after concomitant ingestion of nonsteroidal anti-inflammatory drugs and binge drinking. This acute tubular necrosis is likely to have an hemodynamic origin due to nonsteroidal anti-inflammatory drugs in a patient with volume contraction secondary to binge drinking. The risk appears to be even more important since ethanol has been implicated in tubular necrosis by direct toxicity. This observation underlines the danger in associating nonsteroidal anti-inflammatory drugs and ethanol.

Acute Kidney Injury↗
PubMed1996

[Sweet's syndrome and aseptic abscess of the spleen].

Extra-cutaneous manifestations of neutrophilic dermatosis are exceptional and diverse: they consist of inflammatory infiltrates with neutrophil polymorphonuclears, without evidence of infectious agents. Localisations to the lung are the most frequently observed. A single observation of spleen involvement has been reported in a case of Sneddon-Wilkinson's disease. Herein we report the case of an aseptic splenic abscess during the course of a Sweet's syndrome.

Abscess↗