Generation of thromboxane A2-like activity from prostaglandin endoperoxides by polymorphonuclear leukocyte homogenates [proceedings].
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Animals↗
Biomedical subjects
S Bunting
Publications and source records attributed to S Bunting.
Inhibition of platelet activation by prostacyclin: possible consequences in coagulation and anticoagulation.
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Anticoagulants↗
Synthesis and structure of the platelet aggregation factor thromboxane A2.
In 1975, Hamberg et al. reported evidence for the existence of an unstable platelet-aggregating factor which they named thromboxane A2 (TXA2) and for which they proposed a novel bicyclic oxetane structure (1, below) based on the short half-life of the factor (t1/2 (37 degrees C) = 32 s at pH 7.4) and the isolation of degradation products related to thromboxane (TXB2) (2, below). As natural TXA2 has not yet been isolated and characterized as a pure compound, we have synthesized the proposed structure (1) from TXB2 and compared its biological properties with those of authentic, biologically generated material. Here we present evidence that synthetic material having structure (1) is indistinguishable from platelet-derived TXA2 in various biological assays and that the proposed structure (1) for TXA2 is correct.
Blood Platelets↗
Ethical decision making by nurses in HIV/AIDS situations.
The purpose of this study was to assess the ethical decision making levels of nurses in HIV/AIDS situations. Using an adapted form of Crisham's Nursing Dilemma Test, RNs in various settings in Ohio ranked their reasons for action in responding to vignettes. Findings suggest that nurses are basing their clinical decisions in HIV/AIDS situations on practical considerations rather than on nursing principles. Education programs based on the findings from this study will enhance the use of nursing principles.
Acquired Immunodeficiency Syndrome↗