Thyroid function tests. Doing more tests is not always better.
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Diagnostic Tests, Routine↗
Biomedical subjects
S Bulusu
Publications and source records attributed to S Bulusu.
Cholesterol screening and management guidelines. Having several guidelines is confusing.
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Europe↗
Ethnic differences in outcome of serum screening for Down's syndrome. For appreciable ethnic differences in false positive rates, use different cut off points.
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Asia↗
Assessing blood glucose control in diabetes mellitus. Variant haemoglobin may affect measurements.
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Blood Glucose↗
A patient's charter for laboratories.
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Humans↗
Profile of drug metabolizing enzymes in rats treated with parathion, malathion, and phosalone under various conditions of protein energy malnutrition.
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Animals↗
Effect of subacute administration of three organophosphorus pesticides on the hepatic phosphatases under various nutritional conditions.
In developing countries, extensive use of pesticides to meet with increased agricultural needs is inevitable and the indiscriminate use has led to several toxicological implications in humans. The toxic effects, however, to a large extent depend on the nutritional status of the individuals. In the present work, the hepatic susceptibility to pesticide toxicity has been studied in experimental animals maintained on diets containing different levels of protein for a period of 3 weeks. Along with protein deprivation, the rats were also exposed to three organophosphorus pesticides, viz., parathion, malathion, and phosalone, individually at various doses for the same time period. Phosphatases, the functionally important enzymes of the liver, were estimated and the results obtained indicated that protein deprivation further aggravated the pesticide-induced effects on the hepatic phosphatases.
Acid Phosphatase↗
Hyperphenylalaninaemia in parenterally fed newborn babies.
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Humans↗
Subacute administration of organophosphorus pesticides and hepatic drug metabolizing enzyme activity in normal and malnourished rats.
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Animals↗
Augmented hepatic susceptibility to malathion toxicity in rats on low-protein diets.
With an increasing world population, use of pesticides is unavoidable. However, indiscriminate use of these chemical agents has resulted in several incidents of human intoxication. Toxic effects of human exposure may be influenced by their nutritional status. Effects of malathion, an organophosphorus insecticide, on the hepatic lipid and protein levels and GOT, GPT, and beta-glucuronidase activities in rats maintained on 16, 6, and 1% protein diets for a period of 3 weeks is reported. The doses of malathion used were 5, 50, 250, and 500 mg/kg body wt, administered 24 hr prior to decapitation. The results obtained indicated that malathion induced alterations in enzyme activity; lipid and protein levels were further perturbed by the dietary protein deficiency.
Alanine Transaminase↗
A prospective study of intrapulmonary fat accumulation in the newborn lung following intralipid infusion.
In order to assess the safety and stability of a parenteral fat emulsion (Intralipid) in total parenteral nutrition (TPN), 29 infants were infused Vamin glucose and Dextrose electrolyte solution as well as one of two isocaloric regimens; either 25% Dextrose (Group I) or 10% Intralipid (Group II). Regular biochemical monitoring was performed in all cases and no infants became lipaemic nor developed abnormally high levels of total free fatty acid. Eight infants died and only those who had received fat emulsion had lipid staining material distending the pulmonary vessels. One infant having low infusion rates of Intralipid had massive fat accumulation in the lungs, but biochemistry during life had been normal. We speculate that in ill infants the emulsion becomes less stable and agglomeration of fat particles occurs which are then fully filtered out by the lungs before metabolism of the exogenous fat can occur.
Clinical Trials as Topic↗
Circulating gonadotropin profile in severe cases of protein calorie malnutrition.
The circulating levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and prolactin (PRL) were studied in children of both sexes between 2 and 14 years of age who were suffering from severe protein calorie malnutrition (PCM), namely, kwashiorkor, marasmic kwashiorkor, and marasmus. LH and FSH levels in all the age groups and in all forms of PCM were found to be significantly lowered, thereby explaining the possible delay in the onset of puberty in these children. Circulating PRL levels, on the other hand, were significantly raised in all patients with PCM studied, with values in children with kwashiorkor and marasmic kwashiorkor higher than in children with marasmus, possibly accounting for the presence of edema in the former cases. The present work, therefore, proposes a possible correlation between gonadotropin levels and PCM in children.
Adolescent↗