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Biomedical subjects

S Brownstein

Publications and source records attributed to S Brownstein.

123 records · Page 7Linked to original sources
PubMed1976

Bilateral renal agenesis with multiple congenital ocular anomalies.

A 920-g male infant born with features of Potter's syndrome had multiple ocular anomalies. Ocular abnormalities included absence of keratocytes in the inner central corneal stroma, cataract with retention of cell nuclei in the nucleus of the lens, hypoplasia of the ganglion cell and nerve fiber layers of the retina, and absence of nerve bundles in the optic nerve. Other ocular findings including microphthalmos, fetal chamber angle, persistent pupillary membrane , retinal avascularity, and prominent Bergmeister's papilla may have been related to the prematurity of the child.

Abnormalities, Multiple↗
PubMed1976

Complications of corticosteroid therapy in presumptive temporal arteritis.

Two elderly patients presented with symptoms suggestive of occult temporal arteritis. Both were treated with high doses of corticosteroids although subsequent biopsies of the arteries did not show evidence of arteritis. After 5 months of corticosteroid therapy, the first patient died of Gram-negative bacterial pneumonia and cystitis and disseminated intravascular coagulation. The second patient, six days after the biopsy, died of pneumococcal meningitis which had presumably spread from a focus about the left optic nerve. In the first patient, necropsy studies showed that the loss of vision appeared to be due to arteriosclerosis of the nutrient vessels of the optic nerve while in the second patient, the visual symptoms appeared to be due to a localized optic perineuritis. Corticosteroid therapy in elderly patients carries a high morbidity, as is illustrated by the first case and may mask unsuspected underlying disease processes, as presumably occurred in the second. We discuss the importance of obtaining a biopsy diagnostic of temporal arteritis in order to justify the continuation of corticosteroid therapy and the significance of a negative biopsy.

Aged↗
PubMed1976

Tumor-associated antibodies in the serum of patients with uveal melanoma.

Antibodies reacting with autologous and allogeneic cytoplasmic antigens and with autologous surface membrane antigens of uveal melanoma cells were demonstrated in the serum of three patients with relatively small, histologically-proven malignant melanomas of the choroid. The significance of these findings and planned applications of these investigations with regard to diagnosis, prognosis, and therapy of patients with suspected or proven ocular melanomas are discussed.

Aged↗
PubMed1976

Neurofibromatosis with the eye fly Siphunculina funicola in an eyelid tumor.

A 15-year-old Indonesian girl presented with a history of one year of multiple cutaneous tumors including a protuberant mass of the right upper eyelid. Histological findings were consistent with the clinical diagnosis of neurofibromatosis. A cystic cavity in the eyelid tumor contained the eye-fly Siphunculina funicola.

Adolescent↗
PubMed1975

Granulocytic sarcoma of the orbit. Report of a case.

A 14-year-old youth had a 2 month history of proptosis of the left eye when he developed pain in the left thigh. Physical examination revealed a mass involving the left orbit and a neurologic deficit suggestive of involvement of the left lumbosacral plexus. The mass, a left frontal epidural tumor, was removed surgically. Subsequently, he developed marked anemia, thrombocytopenia, and acute granulocytic leukemia. He was treated with various anticancer agents but he did not respond well and he expired two months later. Postmortem examination revealed anaplatic granulocytic cells infiltrating numerous tissues including the conjunctiva, choroid, and leptomeninges. Marked degenerative changes of the left retina and bilateral papilledema were evident.

Acute Disease↗
PubMedDate not supplied

Peters' anomaly: a clinicopathologic study.

Two infants were born with bilateral Peters' anomaly. The first baby was a girl, born prematurely at 35 weeks of gestation and who died 8 days later. The second infant was a boy, born at 38 weeks of gestation, who had severe conotruncal abnormality of the heart. Both babies had distinctive facial dysmorphism and severe central nervous system abnormalities including partial or complete absence of the corpus callosum and cerebral calcifications. Biochemical and genetic investigations showed no abnormalities in either child and there was no family history of genetic disorders. Neither case showed evidence of an intrauterine infection. Postmortem ocular findings in the first infant included bilateral herniation of the ruptured cataractous lens into the posterior corneal defect, iridocorneal adhesions, persistent hyperplastic primary vitreous, and total retinal detachment. The left eye of the second infant was eviscerated at 11 months of age because of recurrent, spontaneous perforation. Pathologic ocular findings included large fragments of lens material adherent to the posterior corneal stroma through a large central defect in Descemet's membrane and endothelium, fibrovascular proliferation of the adjacent corneal stroma, and iridocorneal adhesions.

Cornea↗
PubMedDate not supplied

Alveolar soft-part sarcoma of the orbit.

Alveolar soft-part sarcoma is a malignant soft tissue neoplasm that involves mainly the deep soft tissues of the extremities, particularly the thighs and the buttock. Involvement of the orbit is uncommon. We describe a young child with such a tumor and illustrate the characteristic features.

Antineoplastic Combined Chemotherapy Protocols↗