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Biomedical subjects

S Brown

Publications and source records attributed to S Brown.

At least 433 records · Page 24Linked to original sources
PubMed1993

Axial mesodermal dysplasia spectrum.

We report on a 4-month-old boy with manifestations of both the oculo-auriculovertebral spectrum and the caudal regression sequence. He has preauricular appendages, thoracic and lumbar hemivertebrae, anomalies of the ribs, dextrocardia, sacral "dysplasia," dislocated hips, bilateral talipes equinovarus, imperforate anus, recto-vesical fistula, malformed scrotum, and undescended testes. As suggested by Russell et al. [1981], who reported a patient with similar anomalies, the spectrum of anomalies probably is due to a generalized alteration in mesodermal cell migration during the primitive streak period. The term "axial mesodermal dysplasia spectrum" best describes the widespread anomalies in the cranial and caudal regions.

Abnormalities, Multiple↗
PubMed1993

Binuclear centre structure of terminal protonmotive oxidases.

The recent proliferation of data obtained from mutant forms of cytochrome oxidase and analogous enzymes has necessitated a re-examination of existing structural models. A new model is proposed, consistent with these data, which brings several protonatable residues (Y244, D298, D300, T309, T316, K319, T326) into the vicinity of the binuclear centre, suggestive of a proton-transferring function. In addition, we also consider those residues which may participate in electron transport between CuA and haem a. We suggest several potential lines of investigation.

Amino Acid Sequence↗
PubMed1993

Preliminary definition of a "critical region" of chromosome 13 in q32: report of 14 cases with 13q deletions and review of the literature.

We report on 14 patients with partial deletions of chromosome 13q. These patients exhibit a wide spectrum of phenotypes. Deletions limited to proximal bands q13-q31 are associated with growth retardation but not with major malformations. We review the literature since 1975 and summarize 13q deletion cases which have a phenotype involving one or more major malformations and mental retardation. Analysis of the breakpoints of these cases, as well as those reported by us, supports the hypothesis that only deletions involving at least part of band q32 are associated with major malformations and digital abnormalities. Patients with more distal deletions have severe mental retardation but do not have major malformations or growth retardation. A group of patients in whom the breakpoint is stated to be within q32 has had an intermediate phenotype. This suggests that it may be possible to define subregions within q32 whose deletion is associated with particular developmental defects.

Chromosome Aberrations↗
PubMed1993

Characterization of ligand binding to immobilized biotinylated extracellular domains of three growth factor receptors.

For the purpose of developing a cell-free binding assay suitable for the large scale screening of receptor agonists and antagonists, the extracellular ligand binding domains of the low affinity NGF receptor (p75NGFR), a splicing variant of the fibroblast growth factor receptor (FGFR), and the PDGF beta-receptor (PDGFR) were modified by the biotinylation of amino groups. After immobilization in streptavidin-coated microtiter wells, it was determined by ligand binding analysis that all three receptors retained high affinities (0.7-1.8 nM) for their respective ligands. Two receptors, p75NGFR and FGFR, also displayed low affinity ligand binding (45-85 nM) which is likely a result of differential biotinylation. The three assay systems displayed excellent tolerance to several solution variables including organic solvents and high salt, with the exception of the FGF assay's sensitivity to thiols. The consistency obtained by using a coated well protocol, coupled with elimination of cell culture while maintaining natural binding affinities, demonstrates that the immobilized biotinylated extracellular domain creates an excellent system for pharmaceutical screening.

Animals↗
PubMed1993

An epilepsy needs document.

Services for epilepsy in the UK are poor in quality, fragmentary and poorly organized. We attempt to define and quantify the scope, content and standards of medical, paramedical and nursing services required, from primary health care to specialist centres. This document has been approved by the Joint Epilepsy Council of Great Britain and Ireland, representing all major patient organizations and care providers.

Cross-Sectional Studies↗
PubMed1993

Research testing theory: a selective review of Orem's self-care theory, 1986-1991.

The purpose of this study was to determine the extent to which theory testing may have increased in the 5 years since Silva's initial investigation. Using the criteria established by Silva, a review of five major research journals in nursing was used to investigate the degree to which Orem's self-care theory of nursing was being empirically tested. Hand and computer searches yielded 31 studies purporting to use Orem's theory as the basis for research. Of these studies, however, only four (13%) met the criteria for appropriately testing the theory. The findings indicate that little change has occurred in using research to test Orem's theory appropriately. Implications for research and practice are discussed.

Humans↗
PubMed1993

Prevalence of self-medication with antibiotics among patients attending a clinic for treatment of sexually transmitted diseases.

To ascertain the prevalence of self-medication with antimicrobial agents among patients attending a clinic for treatment of sexually transmitted diseases (STDs), we administered a questionnaire to and collected a urine specimen for antimicrobial testing from 551 patients before treatment. We defined self-medication as an antimicrobial agent taken on the patient's own initiative by self-report during the week before the visit to the clinic or a positive urine assay for antimicrobial agents at the time of the clinic visit. We tested urine for the presence of antimicrobial agents by a disk diffusion method using Sarcina lutea as the test organism. A total of 75 (14%) of the 551 participants were self-medicators: 19 reported antimicrobial use and had a positive urine test, 27 reported antimicrobial use but had a negative urine test, and 29 denied antimicrobial use but had a positive urine test. Thus, 29 (60%) of the 48 patients with antimicrobial agents detected in their urine at the time of the clinic visit denied self-medication. Self-medicators acquired their antibiotics either from their medicine cabinet (44%) or from a family member or friend (56%). Self-medication was associated with self-report of prior use of unprescribed antimicrobial agents (P < .0001). We concluded that use of unprescribed antimicrobial agents (usually beta-lactam agents or tetracyclines) among STD clinic attendees in our study was common and that self-reporting was not a reliable method of screening for self-medicators.

Adult↗
PubMed1993

Attenders and nonattenders at childbirth education classes in Australia: how do they and their births differ?

This study assessed the associations between attendance at childbirth preparation classes and the health behaviors, birth events, satisfaction with care, and later emotional well-being of women having their first child. A postal survey was conducted of a population-based cohort of 1193 women who gave birth in two weeks in 1989 in Victoria, Australia. The response was 71.4 percent (790/1107). Classes were attended by 245 (83.9%) of 292 primiparous women. Those who did not attend were significantly more likely to be under age 25 years, not to have completed secondary education, to be single, to have a low family income and no health insurance, and to be public hospital clinic patients. Differences between women who attended classes and those who did not, with respect to measures of pain and to the use of procedures, interventions, and pain relief, were rare and minor. No differences occurred between the groups in their satisfaction with the provision of information through pregnancy, birth, and the postnatal period. Only one of five measures of satisfaction with care was less favorable in nonattenders. Attenders were not more confident about looking after their infants at home or less likely to be depressed eight months after birth. Significant differences occurred between the groups on four health behaviors: cigarette smoking, missed antenatal appointments, breastfeeding, and alcohol consumption during pregnancy. Attendance at childbirth preparation classes in Victoria is not associated with differences in birth events, satisfaction with care, or emotional well-being among women having their first child.

Adult↗
PubMed1993

Antenatal care: a case of the inverse care law?

As part of a review of maternity services this study assessed satisfaction with antenatal care among 1193 women who gave birth in Victoria during two weeks of 1989, except for those who had a stillbirth or whose infant died between the birth and the survey. The survey questionnaire was mailed to women eight to nine months after the birth. The response rate, excluding duplicates, women who gave birth outside the survey period and those whose questionnaires were returned because of a change of address was 71.5 per cent. Women attending public hospital clinics were the least satisfied with antenatal care and those attending private obstetricians were the most satisfied, with general practitioners intermediate. These differences by provider accounted for almost all the differences by sociodemographic factors (age, marital status, family income, being of non-English-speaking background and health insurance status). While the majority of women were happy with their antenatal care, an inverse care law still applied: women whose economic and social circumstances meant they were most likely to need 'care' from caregivers were more likely to be limited in their choice of caregiver and to be dissatisfied with the care they received.

Adult↗