What computerized housekeeping can do for you.
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Computers↗
Biomedical subjects
S Brooks
Publications and source records attributed to S Brooks.
Long-term follow-up evaluation of screw-and-graft fusion of the lumbar spine.
The long-term results of 134 screw-and-graft fusions of the lumbar spine for treatment of chronic low-back pain with or without acute sciatic nerve symptoms were observed for over 16 years. Clinically, the results were excellent or good in 80% of patients at a mean review interval of nine years. There were no differences in success rates between single-level L4/5 and lumbosacral fusion or two-level fusions. Ninety-seven percent of patients returned to their previous occupation within six months. Screw-and-graft fusion is recommended as an effective method of treatment in management of selected cases of intractable low back pain.
Adolescent↗
Osteosarcoma after the fourth decade. A clinico-pathological review.
Of 160 cases of osteosarcoma seen over an 18-year period, 18 were over the age of 40 at the time of presentation. The clinical presentation and histology of these cases is reviewed. Delay in referral and incorrect histological diagnoses were frequent. Only 2 cases were associated with Paget's disease.
Adult↗
Pancreatic and intestinal digestive enzymes in post-weanling rats with hypothalamic obesity.
Male Sprague-Dawley rats received bilateral electrolytic lesions in the ventromedial hypothalamic nuclei (VMNL rats) at the age of 31 days; sham-lesioned rats served as controls. For 28 post-operative days all animals self-selected from three synthetic diets, each high in carbohydrate, fat and protein, respectively. Following this, half of the VMNL rats and half of the controls were switched to lab chow for 14 days. Body weights were comparable among the groups, but linear growth was greatly reduced and body fat (Lee Index) was elevated in VMNL rats, irrespective of diet. In the sham-lesioned controls, the synthetic diets reduced most parameters of exocrine pancreatic activity. In VMNL rats, in contrast, pancreatic parameters were unaffected by the synthetic diet. The data suggest that VMN lesions disinhibit the exocrine pancreas. In contrast, most parameters of intestinal activity were not influenced by VMN lesions.
Animals↗
The diversity of reaginic immune responses to platinum and palladium metallic salts.
As part of a National Institute for Occupational Safety and Health health hazards evaluation, workers employed in a precious metal refinery exposed to platinum (Pt), palladium (Pd), and other group VIII metallic salts were evaluated for direct skin test sensitivity to Pt. Current (107) and former (30) workers who quit or were discharged because of Pt-related health problems were prick tested with ammonium hexachloroplatinate ([NH4]2 PtCl6). Of the 107 currently exposed workers, 15 (14%) exhibited positive skin tests, as indexed by immediate reactivity at a dose of 10(-3) gm/ml or less. Eight (27%) of the 30 former workers no longer exposed to Pt also demonstrated positive Pt skin tests. Sera obtained from the workers were assessed for transferable antibodies to Pt and Pd salts by monkey passive cutaneous anaphylaxis. In addition, Pt-specific antibodies were evaluated by RAST. Results of these studies suggested that short- and long-term passive cutaneous anaphylaxis immune responses occur after exposure to both Pt and Pd compounds. Results of RAST analysis for Pt-specific antibodies indicated that significantly higher (p less than 0.001) levels were present in the sera of skin test-positive workers as compared to control sera from Pt-exposed, skin test-negative workers or nonexposed control subjects. Evidence was also obtained that Pt or Pt-protein adducts present in the sera of exposed workers may compete for IgE-binding sites in the RAST assay. The specificity of the Pt-specific RAST system was proved by inhibition experiments.
Animals↗
Brachial artery damage accompanying closed posterior dislocation of the elbow.
Four cases of arterial damage resulting from closed posterior dislocation of the elbow are described. Two of these have been successfully treated by conservative methods and two by vein graft to the damaged artery. Sixteen previous cases are detailed and the management of this uncommon complication of dislocated elbow is discussed.
Adult↗
Which curing cycle is best?
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Chemical Phenomena↗
Bleomycin infusion followed by cyclophosphamide, methotrexate, and 5-fluorouracil in advanced squamous carcinoma of the head and neck.
Twenty-seven patients with squamous cell carcinoma of the head and neck were treated with bleomycin 7.5 U/m2/day continuous infusion X 3 days (days 1-4, 8-11), followed by cyclophosphamide 300 mg/m2, methotrexate 30 mg/m2 and 5-fluorouracil 300 mg/m2 on days 5 and 12 (bleo-CMF). Treatment was repeated every 28 days. All but two had a performance status of 0-2 and all but 3 patients had received prior surgery, radiotherapy, and/or chemotherapy. Of 24 evaluable patients, 1 had a complete remission (1.9 months) and 4 had partial remissions (3.7, 3.9, 3.9, 4.1 months, respectively) for an overall response rate of 21%. If one excludes 7 patients with prior chemotherapy, the response rate is 5 of 17 (29%). All responders had received both radiotherapy and surgery. The median survival was 4.4 months for the responders and 3.5 months for the nonresponders. Marked hematologic toxicity occurred in eight patients, and contributed to the death of two. Severe pulmonary toxicity occurred in two patients and caused the death of one. Bleo-CMF did not produce a higher response rate than historical single-agent trials and caused significant toxicity. Furthermore, there was no important difference in the survival of responders and nonresponders.
Adult↗
Normal pancreatic and intestinal enzymes in hypophagic growth-retarded rats that received dorsomedial hypothalamic lesions shortly after weaning.
Male weanling Sprague-Dawley rats received bilateral electrolytic lesions in the dorsomedial hypothalamic nuclei (DMNL rats). Sham-operated rats served as controls. After being fed lab chow for two postoperative weeks, the animals were divided into four groups. One group of DMNL rats and controls received a high-caloric diet (high-fat diet, chocolate chip cookies, 32% sucrose solution, potato chips and marshmallows), whereas another group of DMNL rats and controls continued to receive lab chow. The experiment was terminated on the 185th postoperative day. In accordance with previous findings, DMNL rats, irrespective of diet, were lighter and shorter than controls. In addition, DMNL rats fed junk food were lighter than DMNL rats fed lab chow, and junk-fed controls weighed as much as chow-fed controls. Both DMNL rats and controls fed junk food were also shorter and showed higher carcass fat than their chow-fed counterparts. Also, DMNL rats fed junk food had less carcass fat than junk-fed sham-operated controls, whereas in accordance with previous findings, there was no difference between chow-fed DMNL rats and chow-fed sham-operated controls. Irrespective of diet, DMNL rats ate less calories than their respective sham-operated controls. Both absolute and percent pancreas weight and protein/pancreas were unaffected in DMNL rats but were reduced in both junk-fed groups in comparison with their chow-fed counterparts. Both concentrations and contents of pancreatic trypsinogen, amylase and lipase were unaffected in DMNL rats but total activities of all three enzymes were dramatically reduced in the junk-fed compared with the chow-fed DMNL rats.(ABSTRACT TRUNCATED AT 250 WORDS)
Animals↗
Classification of human breast morphology important to bite mark investigation.
There is a great range of variability in human breast size and resiliancy that may have an effect upon the interpretation of bite marks. A proper understanding of the normal range of breast morphology and a system of classification is necessary for an understanding of distortion effects, as well as the precise communication of those effects to others. A classification is given for the morphology of the female human breast following a review of the literature.
Adolescent↗
Sports injuries in an accident and emergency department.
Over a one year period, 2270 sports injuries were seen in the Accident and Emergency Department at the Royal Infirmary, Edinburgh. This represented 3.9% of the total new patients seen in that year. Football and rugby were the most frequent sports responsible for injury. Seventy-eight per cent of injured persons were 26 or under and 88.7% of injuries occurred in men. The two months with the most sports injuries were September and February; 74% (1683) patients stated they trained at least once a week and 85% (1895) played the sport in which they were injured at least once a week. Players who did not train were less likely to incur a severe injury than those who did. Fourteen per cent of the injuries were the result of foul play, but again foul play was less likely to cause a serious injury; 41% of injuries were to the lower limb; 45% of injuries were fractures, dislocations, lacerations and head injuries; 7% of patients required admission to hospital and 22% were referred to a clinic. Seventy-seven per cent of the referrals were to the orthopaedic department. The relevance of these figures to the accident and emergency workload is discussed.
Adolescent↗
Pancreatic growth and enzyme profiles in weanling rats with normophagic hypothalamic obesity.
Weanling male rats with ventromedial hypothalamic lesions (VMNL rats) and sham-operated controls were killed 1, 2, 4, and 5 weeks postoperatively. The VMNL rats developed normophagic hypothalamic obesity in the presence of normal body weight and reduced linear growth. In both VMNL and control rats, pancreatic weight and protein content increased with time but were lower in the lesioned animals. Pancreatic DNA content was arrested in VMNL rats and remained so during the remainder of the experiment. The only significant enzyme changes (trypsinogen, amylase, and lipase) were evident in higher trypsinogen concentration in VMNL rats during 2 and 4 weeks after lesion production. In view of previous data on both hypophysectomized and VMNL rats and the known role of the ventromedial hypothalamic nucleus in neuroendocrine and neuroautonomic function, it is speculated that the changes observed here are in part due to disruption of neuroendocrine and in part due to disturbance of neuroautonomic control systems.
Amylases↗
Effect of chronic reserpine treatment on the pancreases of neonatal rats.
Chronic reserpine treatment of adult rats results in the accumulation of pancreatic enzymes and reduction of their discharge. These changes are reminiscent of those in cystic fibrosis. Since the majority of cystic fibrosis patients have their pancreatic dysfunction manifested in childhood, we studied chronic reserpine treatment in rat pups. Four-day-old rat pups were given reserpine (50 micrograms/kg intraperitoneally) or vehicle daily until sacrifice. The reserpine group showed significant decreases in body weights at 14 and 21 days of age. Pancreatic weights were also decreased but were of normal weight or increased when normalized against body weights. At 14 and 21 days of age, pancreatic concentrations of amylase, lipase, and trypsinogen showed no difference between reserpine and control pups. At both ages, pancreatic contents of all three enzymes were generally less in the treated pups, but were found to be similar when corrected for body weights. Hydrocortisone treatment of 14-day-old pups caused precocious accumulation of pancreatic enzymes in both reserpine and control groups. Intestinal contents of lipase, trypsin, and amylase were decreased in the reserpine pups at 14 days of age and reached a more significant level at 21 days of age; these data suggest a decrease in the secretion of pancreatic enzymes. Dispersed acini from 14-day-old pups showed a reduced capacity to release amylase as stimulated by carbachol or the octapeptide of cholecystokinin. The results suggested that chronic reserpine treatment of pups in the suckling period did not cause significant disturbance of the developmental accumulation of pancreatic enzymes. A definite inhibition of exocrine secretion was found with reserpine treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
Amylases↗
Comparison of bone levels after intramuscular administration of cephradine ('Velosef') or flucloxacillin/ampicillin in hip replacement.
Serum and bone levels of antibiotics were measured after the intramuscular injection of either 1 g cephradine or 500 mg flucloxacillin plus 500 mg ampicillin in 48 patients undergoing total hip replacement. The results showed that both regimens produced adequate blood levels, but that the levels after cephradine were higher and more prolonged. Bone levels of cephradine were significantly higher than for flucloxacillin or ampicillin. In half of the patients studied, flucloxacillin bone levels were below the limit of detection in both cancellous and cortical bone samples. In all 24 patients, cortical levels of cephradine were satisfactory for anti-staphylococcal activity although cancellous levels were unsatisfactory in 4 patients. The penetration of the antibiotics was greater into cortical bone than into cancellous bone.
Aged↗
Interrupted pregnancy as an indicator of poor prognosis in T1, 2, N0, M0 primary breast cancer.
We examined the records of women with primary breast cancer for a history of pregnancy and live births. The patients were all histopathologic T1, 2, N0, M0 white females, untreated post modified radical mastectomy. Patients with a history of interrupted pregnancies have a significantly shorter time to recurrence than those with normal pregnancy history. A trend toward a lower incidence of highly differentiated histological pattern is also observed in cancers from these patients.
Abortion, Spontaneous↗
Quantitative assessment of bacterial invasion of chronic ulcers. Statistical analysis.
Seventy-four bacterial counts were performed on tissue specimens taken from seven chronic decubitus ulcers and two infected postoperative wounds to evaluate the reliability of a single determination as an indicator of the degree of bacterial contamination of the wound. Two methods of tissue sampling were compared. In Group I, a single tissue sample was divided into four specimens, which were then individually processed. In Group II, bacterial counts were made on tissue specimens taken from four widely separated areas of the wound. Data from 37 determinations were available in each group. The 95 percent confidence interval for a single determination was log10 +/- 0.9 for Group I and log10 +/- 1.3 for Group II. We conclude that the range of values at the 95 percent confidence interval is so large that a bacterial count made on a single tissue sample from a chronic ulcer has only limited value as a guide to the surgeon in determining the optimal time required to perform a surgical closure.
Bacteria↗
Vowel-learning and the vowel system of deaf children: age and feedback-related differences.
A study comparing perceptual judgments of vowels produced by deaf children taught to speak by using a computer-based aid (experimental group, E) and by conventional techniques (control group, C) revealed feedback-related differences. These concerned the ability to reorganise articulatory performance, intelligibility of vowels after training, and the strength of the memory trace, which all showed an advantage for the E group. A phoneme-by-phoneme analysis indicated that the E group improved consistently on back and central vowels, whereas no consistent trend was found in the C group. The modifications observed were also age-dependent, more progress was found in the younger than in the older children's performance. An error analysis showed that asymmetric vowel confusions were predominant and that the major factor accounting for all errors was the small difference between second formant values. The findings are discussed in terms of the articulatory and perceptual variables intervening in the vowel intelligibility of deaf children.
Age Factors↗