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Biomedical subjects

S Britton

Publications and source records attributed to S Britton.

At least 163 records · Page 9Linked to original sources
PubMed1969

Regulation of antibody synthesis against Escherichia coli endotoxin. IV. Induction of paralysis in vitro by treating normal lymphoid cells with antigen.

Normal mouse lymphoid cells have been shown to become specifically paralyzed after in vitro exposure to high doses of detoxified endotoxin of Escherichia coli 055:B5. The immune status of the treated cells was tested after transfer to secondary irradiated hosts. Paralysis was shown to be initiated by events taking place in vitro, since the amount of antigen retained on the cells after the in vitro exposure was insufficient to induce paralysis in vivo. The induction of paralysis was dependent on the concentration of antigen added to the cells in vitro. Certain variables, such as time of exposure and temperature at exposure, influenced the ease by which the cells could be paralyzed. Cells pretreated with trypsin were not susceptible to induction of paralysis by the above procedure.

Animals↗
PubMedDate not supplied

The course, costs and complications of oral versus intravenous penicillin therapy of erysipelas.

Oral versus intravenous antibiotic therapy of severe erysipelas was compared in a controlled trial of 60 patients. No clinical benefit of intravenous therapy was found, as evaluated by fever duration, hospital stay and sick leave. Untoward reactions were comparable between the groups. No difference in recurrence was found. The difference in administration time and drug cost was considerable. It is therefore suggested that erysipelas without complications should be treated orally.

Administration, Oral↗