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S Braun

Publications and source records attributed to S Braun.

367 records · Page 21Linked to original sources
PubMedDate not supplied

[Study of the morphology of the intrinsic muscles of the pes cavus using x-ray computed tomography].

From the tomodensitometric examination of 9 cases of hollow foot, the authors present their methodology, reminding the difficulties encountered, and they analyze the results. After a first tomodensitometric study including 16 cases of normal feet, confirming the existence of a suro-achilleo-plantar system by studying correlations between plantar intrinsic muscles and muscles of the posterior compartment of the leg, they establish: the advantage of this method of evaluation of section areas and evaluation of the maximum traction force of the intrinsic muscles of the foot (reproducibility), the disorganization of this anatomo-functional unit in hollow foot syndromes.

Adult↗
PubMedDate not supplied

Immunodiagnosis and immunotherapy of isolated tumor cells disseminated to bone marrow of patients with colorectal cancer.

Micrometastatic spread of viable carcinoma cells is thought to be the leading cause of death in patients with completely resectable colorectal cancer. Since this minimal spread is missed by current tumor staging procedures, immunocytochemistry with monoclonal antibodies to epithelial cytokeratins have been successfully applied to detect individual carcinoma cells disseminated to mesenchymal organs such as bone marrow. Although the skeleton is not a preferential site of overt metastases in colon cancer, individual cytokeratin-positive tumor cells in bone marrow can be detected in about 30% of patients with no clinical signs of overt metastases (stage MO). The presence of these cells in bone marrow at the time of primary surgery turned out to be a strong independent indicator for subsequent relapse in organs such as liver and lungs. In a randomized, multicenter trial it could be furthermore demonstrated that the intravenous administration of the monoclonal antibody 17-1A into patients with Dukes C colon cancer significantly reduced the overall death rate by 30% and decreased the recurrence rate by 27%, thus underscoring the accessibility of micrometastatic tumor cells for immunotherapy. The present article reviews the current state of immunologic strategies used to detect, characterize, and treat minimal residual colon cancer.

Analysis of Variance↗