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Biomedical subjects

S Bousnina

Publications and source records attributed to S Bousnina.

At least 37 records · Page 2Linked to original sources
PubMed1996

[Symptomatic Helicobacter pylori infection: prospective study of epidemiological, diagnostic and therapeutic aspects in children in Tunisia].

BACKGROUND: Epidemiology, criteria for diagnosis and treatment of Helicobacter pylori (HP)-related infection in children are still debated. POPULATION AND METHODS: A total of 130 children and teenagers who presented recurrent episodes of unexplained abdominal pain underwent an endoscopic examination. Gastric biopsies were studied for histology and search for HP (Giemsa and Gram staining, testing for urease and culture in an appropriate environment). Serological tests (Elisa) were performed. HP infection was considered as present when two investigations at least proved positive. Infected children were given one drug (amoxicillin, cimetidine or antiacids) or two drugs (amoxicillin plus tinidazole). Clinical and endoscopic control including histological and bacteriological studies were done for the following 12 to 18 months. RESULTS: HP infection was present in 70 children (54%). It was associated chronic gastritis in 64 cases (91%) and with duodenal ulcer in the remaining cases (9%). Recurrent abdominal pain, anorexia, weight loss and family history of peptic diseases were significantly associated with HP infection (P < 0.05). Endoscopic examination was normal in 35 infected children (50%); nodular antritis was inconstant (30%) but always associated with HP-related infection (P < 0.001) as was atrophic or follicular chronic gastritis. Eradication of HP, associated with the disappearance of chronic gastritis, was seen in 53% of children given amoxicillin alone and in 85% of those given amoxicillin plus tinidazole, but never in those receiving cimetidine or antiacids. Relapse of the HP-related infection was observed in four children (16%), 6 to 12 months after the first episode. CONCLUSION: These results show high prevalence of HP-related infections in the Tunisian children who suffer from recurrent episodes of abdominal pain. They also confirm the role of HP in the inflammatory process and the development of gastroduodenal ulcer in children.

Abdominal Pain↗
PubMed1991

[A new case of relapsing hemolytic and uremic syndrome].

Relapsing hemolytic and uremic syndrome is infrequent in pediatric patients. The case of an infant who had HUS at 11 months of age and subsequently developed two relapses at 3 years and 3 1/2 years of age is reported. Outcome of the first episode was favorable, with no elements suggesting an increased risk for subsequent relapses. Conversely, the second and third episodes were followed by gradual deterioration of renal function and persistence of severe arterial hypertension. To clarify the epidemiology, clinical manifestations, histology, and outcome of HUS, the 24 pediatric cases of relapsing HUS reported in the English-language medical literature were reviewed. In this group, mean age at onset was 4 years 1 month (range 4 months-9 years) and number of relapses ranged from 1 to 14. Evidence of microangiopathy was the most common histologic finding (15/22) but non-specific lesions were seen in some instances. Opinions vary as to the prognosis of relapsing HUS; our case suggests that relapses are of adverse prognostic significance.

Age Factors↗
PubMed1990

[Infantile spasms and lissencephaly. Apropos of 2 cases].

Lissencephaly is a rare brain anomaly characterized by a lack of cerebral sulci and gyri. We report 2 cases of lissencephaly syndrome with infantile spasms diagnosed by CT-Scan. We discuss the relationship between lissencephaly and infantile spasms, and attempt to estimate the frequency of infantile spasms in lissencephaly and the frequency of this cerebral abnormality among other etiologies of infantile spasms. The prognosis of infantile spasms is indeed variable, according to the presence of underlying cerebral abnormality.

Brain↗
PubMed1989

Laron dwarfism and mutations of the growth hormone-receptor gene.

Laron dwarfism is associated with resistance to growth hormone (GH). To investigate its genetic basis, we used genetic linkage to test whether the disorder results from a defect in the gene for the human GH receptor. Denaturing gradient gel electrophoresis and sequencing of specific GH-receptor-gene fragments allowed us to characterize specific intragenic DNA markers in 35 control subjects of Mediterranean descent, for use in linkage studies. In two Mediterranean families in which the parents were consanguineous and some of the children had Laron dwarfism, the disease trait and DNA polymorphisms were inherited together. Moreover, an analysis of the GH-receptor-gene RNA transcripts in lymphocytes from one of these families allowed us to identify a thymidine-to-cytosine substitution that generated a serine in place of a phenylalanine at position 96 in the extracellular coding domain of the mature protein. This defect probably affects the receptor adversely and is probably responsible for the lack of plasma GH-binding activity in the patients. This mutation was not found in the GH-receptor genomic sequences of seven unrelated subjects with Laron dwarfism who belonged to different population groups. An analysis of the GH-receptor markers in these patients indicated that different gene frameworks (polymorphic sites within the single gene) were associated with the mutant alleles. We conclude that Laron dwarfism is due to abnormalities in the gene for GH receptor, which may differ from family to family.

Base Sequence↗
PubMed1989

[Gastric duplications in children. Apropos of a case manifested in a newborn infant].

We report a case of gastric duplication with neonatal manifestations. Diagnosis of this infrequent malformation is readily established in most cases upon roentgenologic and ultrasound examinations. Etiopathogenesis is unknown. Therapy is surgical. Complete exeresis involves mutilation because the supernumerary stomach shares the vascular supply to the normal stomach, and because a cleavage plane is lacking. Therefore, incomplete resection should be performed as the condition is benign and good results are consistently achieved with this procedure.

Gastrectomy↗
PubMed1987

Radiological abnormalities of the skeleton in patients with sickle-cell anemia. A study of 222 cases in Tunisia.

The way in which bones are affected in cases of sickle-cell anemia is well known. Nevertheless, advances in treatment and in methods of transfusion mean that we are increasingly seeing cases of older patients with this disease. A retrospective analysis of 222 cases of sickle-cell anemia demonstrates the radiological appearance of the skeleton in the disease and reveals the various bone segments which are particularly vulnerable at certain periods of life. Correlation of X-rays permits the discovery of lesions which are not clinically apparent. The frequency and characteristics of epiphyseal osteonecrosis and osteitis are studied. Aggravation of the bone lesions when corticoids are administered poses the problem of differential diagnosis of the disease, especially in comparison with rheumatic fever.

Adolescent↗