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Biomedical subjects

S Borelli

Publications and source records attributed to S Borelli.

At least 55 records · Page 3Linked to original sources
PubMed1985

[Fertility of smokers and nonsmokers].

The contradictory findings concerning the influence of smoking on spermatogenesis that have so far been presented in literature were derived from fertility patients in retrospective studies; our data, in contrast, are based on a blind study of 333 voluntary test persons. The data of 95 smokers and 83 non-smokers remained to be evaluated after application of the following exclusive criteria: comparatively high consumption of alcohol, taking of drugs, taking of medicine, radioactive exposure, and genital diseases. Significant differences between the two groups were only found with regard to behavior; smokers revealed a higher rate of divorces, they drank alcohol and took drugs more frequently, and had had the first sexual intercourse at an earlier age than non-smokers. On the other hand, all spermatological parameters as well as the outcome of cytophotometric examination of the spermatozoon DNA showed a close correlation between smokers and non-smokers. Although an individual (toxic?) reaction to tobacco smoking cannot be ruled out, our findings lead to the conclusion that cigarette smoking has no detrimental influence on the spermatogenesis of healthy men between the age of 20 and 40.

Adult↗
PubMed1982

Studies on bacterial hypersensitivity in man. Interrelationship between skin reactions to bacterial peptidoglycan and serum peptidoglycan antibody titers.

The nature and extent of bacterially induced allergies are difficult to define. Since peptidoglycan, the main component of the cell wall of almost all bacteria, has been available in a highly purified, chemically and immunologically well-defined form, investigation of the allergological significance of this cell component is feasible. Intracutaneous tests were carried out on 181 test subjects with five different peptidoglycan (PG) preparations from Staphylococcus aureus, Staphylococcus epidermidis and Streptococcus Pyogenes. The results of the investigation were compared with the result of determination of serum PG antibodies and serum IgE concentrations. It was shown that test subjects with dual and later reactions to three different staphylococcal PGs displayed significantly higher PG antibody titers than test subjects with negative reactions. Such a relationship could not be found with the cutaneous reactions to streptococcal PG. The total serum IgE values were very much higher in test subjects with immediate reactions to staphylococcal PG than in test subjects with a negative reaction. Typical Arthus reaction or late granulomatous reactions were not observed. Humoral antibodies are involved at least in part in the elicitation of dual and late reactions. Thus, there are interesting parallels to allergy to fungal spores and organic dusts.

Adolescent↗
PubMed1980

[Skin reactions to isolated bacterial cell wall components, bacterial peptidoglycan in particular].

To elucidate the pathogenetic mechanism of bacterial-allergical diseases and of reactions provoked by bacterial test substances (e.g. the intracutaneous test), it is necessary to analyse carefully various factors involved in these reactions. To try to separate toxic from immunological reactions minute amounts of peptidoglycan in four different preparations were applied to humans by intracutaneous injections. Peptidoglycan, an immunologically well defined wall components of almost all bacteria and which is therefore ubiquitous, was isolated from staphylococci and streptococci. The skin reactions were evaluated by macroscopical, microscopical and immunohistological observations, as well as by electromicroscopy and statistical means. Several findings indicate the involvement of immunological factors in the observed skin reactions. In some cases no measurable reaction was seen, whereas in others typical skin reactions occurred. Similar reactions were produced by the antigenically related peptidoglycans isolated from Staphylococcus aureus and Staphylococcus epidermis. These reactions differed, however, from those elicited by peptidoglycan preparations from Streptococcus pyogenes type A. Patients with chronic bacterial infections and who were injected by four bacterial preparations demonstrated a significant increase in delayed hypersensitivity reaction compared with two other groups of patients (atopic patients without chronic infection). Because of the very low test dose, necrotic skin reactions, which occur in animal experiments, were not observed.

Antigens, Bacterial↗
PubMed1980

[Treatment of seasonal asthmatic symptoms. A multicentre trial to compare the effects of ketotifen and disodium cromoglycate (author's transl)].

A randomized multicentre trial was done to investigate the protective effects of ketotifen and disodium cromoglycate (DSCG) in the therapy of bronchial asthma. 236 patients with seasonal asthmatic symptoms were treated and controlled in the summer of 1978. Both drugs showed a significant improvement of the lung function and a marked reduction of asthmatic symptoms, cough and expectoration.

Adrenergic beta-Agonists↗