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Biomedical subjects

S Boncinelli

Publications and source records attributed to S Boncinelli.

At least 37 records · Page 2Linked to original sources
PubMed1989

Defibrotide in extracorporeal circulation on healthy rabbits.

Defibrotide, a partially depolymerized DNA fraction obtained from mammalian lung, was found to have significant antithrombotic and fibrinolytic activities. On the basis of this evidence defibrotide could be of clinical value during hemoperfusive treatment. The present study was designed to evaluate the biological tolerance of this technique in a model of extracorporeal circulation, using an original Silastic apparatus, with defibrotide (0.83 mg/kg-1/min-1 after a 50 mg/kg-1 bolus injection) and heparin (0.66 IU/kg-1/min-1 after a 400 IU/kg-1 bolus injection) in ten rabbits (Group 1) and heparin only in ten others (Group 2, control group). In this study defibrotide produced a significantly lower pressure inside the circuit compared to the control group and gave a protective effect against those pathological changes which appeared during extracorporeal circulation and that may be considered omens of a state of shock. However the use of defibrotide in addition to heparin seemed to have a poor effect on platelet and leukocyte count alterations during application of this technique.

Animals↗
PubMed1987

Experimental study of argon laser-induced microthrombosis during PGI2 infusion.

In order to evaluate the Argon laser-induced microthrombogenesis during prostacyclin (PGI2) infusion on newly formed microcirculation in the rabbit ear chamber, time-space parameters have been calculated in 118 observations subdivided into 4 groups according to the type and size of the vessels irradiated. The observations were carried out without drug treatment, with continuous infusion of pH 10.5 glycine buffer and with continuous infusion of PGI2 at the dosage of 125 ng X kg-1 X min-1 diluted in the glycine buffer. The results indicated that during PGI2 infusion the size of the thrombus, measured by maximal thrombus area, was always significantly less extended than in untreated animals. Moreover, the number of emboli detached during the first 5 min after laser exposure, measured by rate of embolization, during PGI2 infusion in venules and in the larger arterioles was smaller than in untreated animals. The vasoconstriction which usually takes place in the arteriolar vessels--upstream and downstream from the irradiated site--was in no way modified by the infusion of PGI2. Finally, it was noted that glycine buffer infusion showed an unforeseen activity on laser-induced vascular reactivity.

Animals↗