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Biomedical subjects

S Blika

Publications and source records attributed to S Blika.

26 records · Page 2Linked to original sources
PubMed1984

ABO-blood groups and D-antigen in simple and capsular glaucoma.

ABO-blood groups and Rh-factor (D-antigen) were determined in 236 patients with POAG, 104 simple and 132 capsular glaucoma. There was a statistical significant difference in the ABO-distribution between the two glaucoma subgroups, and also between the capsular-group and our control material. The simplex-group did not differ from the control material in this respect. For the Rh-group (D-antigen) no differences were found, neither between the two glaucoma subgroups nor between each of them and a reference material.

ABO Blood-Group System↗
PubMed1983

Pharmacokinetics and tissue penetration of ceftazidime: studies on lymph, aqueous humour, skin blister, cerebrospinal and pleural fluid.

The elimination kinetics and penetration of ceftazidime into skin blister and lymphatic fluid were studied in nine healthy volunteers following a 1 g iv bolus injection. From the concentration time curve in plasma the following pharmacokinetic parameters (mean +/- S.D.) were calculated: elimination half-life 1.85 +/- 0.33 h; area under the curves 127 +/- 12 mg . h/l; apparent volume of distribution: 21.1 +/- 2.61; total plasma clearance: 133 +/- 13 ml/min and renal clearance: 109 +/- 7 ml/min. Urine recovery after 8 h was 82% of the administered dose. Nearly the same elimination rate constant, half-life and area under the curve were demonstrated for blister fluid and lymph. The penetration of ceftazidime into cerebrospinal fluid (n = 19), aqueous humour (n = 21) and pleural effusions (n = 5) were studied in patients after a 2 g iv bolus injection. In patients with normal meninges (n = 14) the penetration was poor: the concentrations were less than 1 mg/l. In patients with meningitis (n = 5) levels of 18, 17, 16, 1 and 0.8 mg/l were found. Aqueous humour penetration was satisfactory, and a mean concentration of 11 +/- 4 mg/l corresponding to a penetration ratio of 19% was found. The penetration of ceftazidime into large pleural effusions was also good with concentrations from 17 +/- 3 to 28 +/- 2 mg/l, corresponding to a mean penetration ratio of 38%.

Adult↗
PubMed1982

Homocystinuria treated with pyridoxine.

Four cases of homocystinuria with lens luxation have been examined. As judged from the plasma amino acid pattern, they all responded well on pyridoxine treatment. Two of them discontinued the treatment on their own, and one of these died at the age of 17 years. The lens luxation progressed in one case despite adequate treatment. Scanning electron microscopy of one lens revealed partly broken zonules, abnormal zonular attachment, and a spongy appearance of the capsule proper. Hoping that adequate treatment will reduce more serious complications such as thromboembolism in these patients, it is concluded that an early diagnosis largely depends on the ophthalmologist, who should perform the silver-nitroprusside test, specific for homocystinuria, in all patients with non traumatic lens luxation.

Adolescent↗
PubMed1982

Ophthalmological findings in pupils of a primary school with particular reference to reading difficulties.

200 good readers and 41 poor readers selected from 718 pupils in a primary school, grade 1-6 were examined in respect of stereopsis, visual acuity, phorias, tropias, fusional breakpoint, fusional amplitude and objective refraction. No statistical difference was found between the 2 reader groups, and the need for optical aid was of the same order. 80 of the 241 children had unnecessary glasses, and many of those who needed spectacles were improperly aided.

Age Factors↗
PubMed1982

Timolol maleate in the treatment of glaucoma simplex and glaucoma capsulare. A three-year follow up study.

180 eyes of 97 patients with primary open angle glaucoma and IOP greater than 22 mm were treated for more than 3 years with timolol-maleate. 130 eyes had glaucoma simplex, and 50 eyes had glaucoma capsulare. With timolol maleate as the only medication after 3 years, the IOP was controlled in 33% of the glaucoma simplex group, and in 8% of the glaucoma capsulare group. No serious local or systemic side-effects were observed.

Aged↗
PubMed1980

Pulsed Doppler ultrasound for measuring blood flow velocity in the human ophthalmic circulation.

This study was performed in order to develop a method for studying blood flow in the ophthalmic circulation. Using a pulsed doppler system utilizing an ultrasonic frequency of 10 MHz, blood flow velocities have been measured in the ophthalmic artery and in the arteries behind the eyeball (lateral posterior ciliary arteries) in 40 normal subjects. The mean of the peak systolic velocities were 34 +/- 6 cm/s in the ophthalmic artery, and 14 +/- 3 cm/s in the lateral posterior ciliary arteries. We conclude that blood flow velocities can be measured in defined vessel areas in the orbit.

Adolescent↗