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Biomedical subjects

S Bishop

Publications and source records attributed to S Bishop.

53 records · Page 3Linked to original sources
PubMed1983

Changes in cognition with pharmacotherapy and cognitive therapy.

A treatment trial comparing cognitive therapy and pharmacotherapy, alone and in combination, in depressed out-patients, indicated that outcome on cognitive variables was similar to outcome on mood and severity measures, pharmacotherapy being less effective than cognitive therapy or the combined treatment in a hospital and a general practice sample. While combined treatment was superior to cognitive therapy in the hospital out-patients, the two treatments were equivalent in the general practice. Significant effects were obtained on measures of views of self, the world and the future, whose validity was demonstrated. The pattern of change through treatment showed the same order of progress for responders, while non-responders to cognitive therapy tended to do worst. The specificity of treatment effect is discussed.

Adolescent↗
PubMed1981

The efficacy of cognitive therapy in depression: a treatment trial using cognitive therapy and pharmacotherapy, each alone and in combination.

We report an extensive study which compares cognitive therapy, antidepressant drugs and a combination of these two, in depressed patients seen either in general practice or an out-patient department. One-hundred and forty patients were screened for primary major depression and 64 patients completed the trial. All were rated on seven measures of mood, including independent observer-rated and self-rated depression and scales of anxiety and irritability. Patients were randomly assigned to cognitive therapy, antidepressants or a combination of the two. The antidepressant drug group did less well in both hospital and general practice and combination treatment was superior to drug treatment in both hospital and general practice. In general practice, cognitive therapy was superior to drug treatment. The presence of endogenous features did not affect response to treatment. The results are discussed in terms of Beck's cognitive theory of depression and factors of presumed causal importance of depression in general practice.

Adolescent↗
PubMed1981

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Animals↗
PubMed1979

Ingestion of dyed-opsonised yeasts as a simple way of detecting phagocytes in lymphocyte preparations. Cytophilic binding of immunoglobulins by ingesting cells.

Procion-dyed yeasts which have been incubated in fresh serum and washed are readily ingested by human blood monocytes and tumour macrophages during a 30 min incubation period. Uptake is enhanced by centrifugation. Intracellular yeasts can be readily distinquished from extracellular by their much slower uptake of toluidine blue. Yeast ingestion is a much more reliable test for blood monocytes than the latex bead test and it is easier to read. The ingestion test may be combined with a rosette test for surface immunoglobulins (SmIg). Since the yeasts take up immunoglobulins from human serum during the complement-coating stage it is necessary, in a combined ingestion-SmIg test, to use fresh serum from another species (sheep) for opsonisation of the yeasts. A technique is described for reducing the number of immunoglobulin-bearing monocytes to a low level with a combined ingestion-SmIg rosette technique to detect residual immunoglobulin-bearing phagocytes.

Animals↗
PubMed1978

Expression of immunoglobin G on blood lymphocytes in chronic lymphocytic leukaemia.

A sensitive rosette test utilizing antibody-coated red cells has been applied to the study of the immunoglobulins on the surface of blood lymphocytes in chronic lymphocytic leukaemia (CLL). Contrary to other reports, IgG has been found to be a common surface membrane immunoglobulin (SmIg) on CLL cells. The reasons for this variation are discussed. Evidence is presented to show that (a) the anti-IgG-coated erythrocytes really are detecting IgG and not a cross-reacting substance, (b) the IgG is intrinsic to the cell and not cytophilically bound and (c) Fc-binding and other artefacts have been excluded. Expression of Ig by individual cells was studied by using mixtures of fluorescein- and rhodamine-labelled red cells coated with various anti-Ig. Fifty-one cases of untreated CLL were tested and the lymphocytes of thirty-eight of these cases bore Ig of a single light chain type. These cases could be classified on the basis of their lymphocyte SmIg as follows: eighteen expressing M and D and G, eleven expressing D and G but not M, six expressing M and D but not G, and three expressing G alone.

Humans↗
PubMed1977

Use of antibody-coated red cells for the sensitive detection of antigen and in rosette tests for cells bearing surface immunoglobulins.

Conditions for an improved chromic chloride method for the attachment of antibody to red cells are described. The method, which is applicable to whole Ig fractions as well as affinity-purified antibodies, is reproducible and has a sensitivity for detection of antigen in the nanogram range. The coated cells may be used in a rosette assay for the detection of cell surface-bound antigens.

Antibodies↗
PubMed1976

Adaptations of the left ventricle to chronic pressure overload.

Left ventricular (LV) function during the adaptation to chronic pressure overload produced by an ascending aortic constriction was analyzed in conscious dogs, instrumented with intraventricular micromanometers and pairs of ultrasonic crystals for measurement of LV wall thickness (WTh) and internal LV chamber diameter. During inflation of the cuff to produce LV pressures averaging 220 mg Hg, calculated peak wall stress (WSt) increased by 55% above control while percent shortening decreased by 24% and mean circumferential shortening velocity (VCF) decreased by 39% from control. By 9 days (mean) after aortic constriction, the cross-sectional area (CSA) of the LV wall increased by 10% and peak WSt fell to 37% above control. End-diastolic diameter (EDD) increased to 4% above control, while percent shortening and mean VCF remained reduced at -12% and -20% of control, respectively. During the phase of concentric hypertrophy (mean 2 1/2 weeks), CSA increased further to 15% above control and WSt fell to 22% above control, while EDD and percent shortening returned to control and mean VCF increased to -7% of control (not significant). At 24 hours after release of the cuff WSt, percent shortening, mean VCF, and peak velocity of LV pressure rise (peak dP/dt) were not significantly different from control. Rapid, partial regression of hypertrophy was observed in some dogs. Thus, the left ventricle responds to chronically elevated pressure by initial dilation with increased WSt followed by gradual wall thickening and consequent reduction of WSt to near normal. After successful adaptation to the pressure overload, hypertrophy per se did not produce intrinsic depression of the myocardial inotropic state.

Animals↗
PubMedDate not supplied

A two-year naturalistic follow-up of depressed patients treated with cognitive therapy, pharmacotherapy and a combination of both.

Depressed patients who had responded to either cognitive therapy, pharmacotherapy or the 2 treatments combined, were followed up retrospectively over a period of 2 years. There were significantly more relapses at 6 months in the pharmacotherapy group compared to the combined treatment group and the 2 cognitive therapy groups together. The number of individuals who relapsed at some point over the 2 years was significantly higher in the pharmacotherapy group than in either of the cognitive therapy groups. When hospital patients were considered separately, significantly more patients in the pharmacotherapy group relapsed over the 2 years compared to the 2 cognitive therapy groups combined. Methodological problems of naturalistic follow-up studies are discussed and the prophylactic potential of cognitive therapy is discussed relative to continuation drug treatment.

Adult↗
PubMedDate not supplied

The strategic power of saying no.

Susan Bishop started Bishop Partners with the aim of making it the best boutique executive-search firm in the business. Specializing in television, radio, and publishing industries, her plan was to beat out her larger, established competitors through superb execution. Great service would lead to happy clients, which would lead to more business, which would keep clients happy, which would lead to even more business. A virtuous circle, right? Wrong. Before long, she and her staff grew weary of jumping through every hoop their clients could think of--trying to find candidates for lower-level positions in remote locations at below-market rates, for instance. But what could they do? How could they afford to disappoint any customer when they didn't have that many to begin with? In this vivid first-person account, Bishop describes how she and her staff came to an answer that was highly counterintuitive: stop trying to make everyone happy. Focus instead on making the right customers happy. Raise their prices. Limit their searches to high level positions in their field of expertise. Stick to companies big enough to give them repeat business. As hard as it was to define the right clients, it was even harder to say no to the wrong clients. One member of the staff had to turn down work worth $120,000; Bishop herself had to turn down $250,000 from her largest client, Coca-Cola. But in the end, those clients came back with higher-quality work, and her company was on its way from chaotic little start-up to successful, professional enterprise. Bishop tells the classic entrepreneur's story, one with important lessons about strategy making, courage, and discipline for all businesspeople.

Consumer Behavior↗
PubMedDate not supplied

Radiographic investigation of palatal incompetence.

The purpose of this article is to describe the radiographic technique by which the author's department investigates the children and adults referred with palatal incompetence. It is not intended to compare it with any other type of investigation. The technique described has been used at Frenchay Hospital for the past 10 years and has yielded very reliable results. The information obtained has led to better planning of treatment for each individual patient.

Adult↗
PubMedDate not supplied

Introduction of solid foods to African American and Anglo American low-birth-weight and full-term infants.

A secondary data analysis of 7,174 infants explores the use of cereal, fruits and vegetables, and meats with African-American and Anglo-American very-low-birth-weight (VLBW), low-birth-weight (LBW) and term infants over the first five months after discharge. The first solid foods offered were cereal for African-American infants and fruits and vegetables for Anglo infants. There are statistically significant differences in the number of feedings offered by the two ethnic groups. During the last two-to-three months, African-American term and LBW infants received all solid foods more frequently than Anglo infants. Neither ethnic group followed current feeding practice recommendations on when to introduce solid food.

Black or African American↗