Biomedical subjects
Publications and source records attributed to S Bianchi.
Thermography was carried out in 28 cases of lymphomas of the superficial lymphnodes. Hyperthermia of lymphnodes that are the site of an active lymphomatous process and its arrest following effective, especially radio, therapy has been confirmed.
In breast cancer the study of prognostic factors has been well developed during last years and many biologic and biochemical parameters have been analyzed. Cell kinetics parameters demonstrated the capability to select patients with different risk of evolution of the neoplasia and in some cases treatment protocols are established by means of proliferation rate. The present study deals with the determination of Thymidine Labelling Index in breast tumors mostly T1-T2 with negative lymph nodes. Results demonstrated that the proliferative activity is higher in younger patients, in T2 cancers compared to T1, and in ductal infiltrating forms compared to the other more frequent histotypes. A significant correlation has been observed between TLI and nuclear grade. The preliminary analysis of the prognostic value of TLI has been two performed using an experimental cut off that is able to discriminate groups of patients with overall survival rate of 67% and 88%, depending on the different proliferative activity of the tumor.
Some patients with essential hypertension manifest increased urinary albumin excretion (UAE). Hypertensive patients with microalbuminuria manifest abnormal circadian variation of blood pressure, increased serum levels of LDL-cholesterol and lipoprotein(a), a greater rise of serum insulin in response to an oral glucose tolerance test, and greater thickness of the carotid artery than patients without microalbuminuria. A 7 year follow-up of 141 hypertensive patients, 54 with microalbuminuria and 87 without microalbuminuria, we observed 12 cardiovascular events in patients with microalbuminuria and only 2 events in the patients with normal urine albumin excretion (P < 0.0002). Creatinine clearance decreased more in patients with microalbuminuria than in those with normal UAE. In conclusion, hypertensive individuals with microalbuminuria manifest a greater incidence of cardiovascular events and more decline in renal function than patients with normal UAE. We propose that measurements of UAE may be a useful marker for cardiovascular risk in patients with essential hypertension.
BACKGROUND: Some patients with essential hypertension display hyperinsulinemia and/or insulin resistance. A relationship between hyperinsulinemia and blood pressure has not been conclusively established. Some evidence points to a relationship between hyperinsulinemia and evidence of cardiovascular damage. OBJECTIVES: In this study, we examined the relationship between insulin secretion in response to an oral glucose load, circadian variation of blood pressure, and evidence of vascular damage, measured by the thickness of the carotid artery and urinary albumin excretion. DESIGN: Seventy patients with essential hypertension and 35 healthy volunteers were included in the study. RESULTS: Twenty patients were hyperinsulinemic. Office blood pressure was not different between hypertensive patients with high and those with normal insulin AUC. However, night-time diastolic blood pressure was greater in hypertensive patients with high insulin AUC (93 +/- 2.9 mm Hg) than in those with normal insulin AUC (83.5 +/- 1.7 mm Hg, P < 0.005). The thickness of the carotid artery and urinary albumin excretion were greater (P < 0.05) in patients with high insulin AUC than in patients with normal insulin AUC and normotensive subjects. Insulin AUC was significantly correlated with ambulatory blood pressure, carotid artery thickness, and urine albumin excretion. Multiple regression analysis using insulin AUC as the dependent variable and UAE, triglycerides, body-mass index and office or ambulatory blood pressure as independent variables showed the strongest correlation with urine albumin excretion (P < 0.0001), triglycerides (P < 0.02) and body-mass index (P < 0.07). CONCLUSIONS: These data suggest that in patients with essential hypertension hyperinsulinemia is associated with higher levels of nocturnal blood pressure, and greater evidence of vascular damage.
INTRODUCTION: Dislocation of the long head of biceps tendon, including subluxation to displacement out of the bicipital groove, is an uncommon cause of shoulder pain. We investigated the role of US in the diagnosis of this condition. MATERIAL AND METHODS: We examined eight patients with dislocation of the long head of biceps tendon: seven had a displaced, and one a subluxated tendon. All patients had early radiographic and US studies of the shoulder; then, three (37%) were submitted to CT-arthrography and two (25%) to MRI. US was performed at 7.5-13 MHz frequency, CT-arthrography with a volumetric acquisition technique and MRI with a surface coil at 1.5 T. Three patients with tendon dislocation had surgical confirmation of the diagnosis. RESULTS: Dislocation of the long head of biceps tendon was always diagnosed with US in all our eight patients; CT-arthrography and MRI confirmed the US findings. In the patient with subluxation of the long head of biceps tendon, US showed the tendon displaced over the lesser tuberosity whereas, in the 7 cases of complete luxations, the groove was empty and the tendon displaced medially. At CT-arthrography, the tendon was well outlined by contrast medium within its sheath. In dislocations, it was close to the anterior aspect of the humeral head. In two cases of dislocation, MRI showed both the empty bicipital sulcus and the medial tendon displacement. The subscapularis tendon tear was always associated with tendon dislocation; a supraspinatus tendon tear was observed in 6 cases. CONCLUSIONS: When imaging a painful shoulder, we should investigate the integrity and course of the long head of biceps tendon. In clinical practice, dislocation of this tendon can be reliably diagnosed with US. CT-arthrography and MRI should be used only to supplement inconclusive US studies.
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