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Biomedical subjects

S Bhalla

Publications and source records attributed to S Bhalla.

34 records · Page 2Linked to original sources
PubMed1993

Gonadal teratomas: a study of 206 cases.

Total 206 gonadal teratomas were diagnosed in Christian Medical College and Hospital, Ludhiana from January 1980 to December 1990. 182 of them were in ovary and other 24 in testis. Majority of them i.e. 45.1% of ovarian and 45.8% of testicular lesions were seen in third decade. On gross examination 161 (88.4%) of ovarian tumours were cystic one (0.5%) was completely solid, while 20 (10.9%) showed solid as well as cystic areas. Majority (93.9%) of them were mature teratomas; 27 (14.8%) being dermoid cysts. In testicular lesions 22 (91.7%) were solid as well as cystic type and 2 (8.3%) were purely solid. Twenty (83.3%) of them were immature and only 4 (16.7%) lesions showed benign histology.

Adolescent↗
PubMed1991

Teratomas of rare sites: a review of ten cases.

Out of 267 cases of teratomas diagnosed in the department of pathology, Christian Medical College and Hospital, Ludhiana, Punjab from January 1980 to December 1989, 10 cases occurred in rare sites ie, 3 cases of teratoma in retroperitoneal space, 3 in the floor of the mouth, one each in mediastinum, thyroid, urinary bladder and kidney. None of these cases was clinically suspected as teratoma. One of the 3 teratomas of the retroperitoneal space and that of kidney were solid. Lesions of mediastinum and urinary bladder were solid as well as cystic. All these teratomas showed foci of immature elements. All other tumours were cystic and contained mature tissues only. Teratomas of the thyroid and kidney were treated with subtotal thyroidectomy and nephrectomy respectively, rest had surgical resection. One patient of immature retroperitoneal teratoma was lost to follow-up. All the others are alive and well for the period of 1 to 8 years. None had recurrence.

Adolescent↗
PubMed1990

Pyloric obstruction due to gastric tuberculosis--an endoscopic diagnosis.

A 22 year old male presented with symptoms of gastric outlet obstruction. Endoscopy showed a hypertrophic nodular lesion around the pyloric opening with pyloric stenosis. The endoscopic biopsy and histopathological examination revealed tuberculosis involving the stomach, an extremely rare lesion.

Adult↗
PubMed1990

Value of clinico-pathological factors in prognosis of breast cancer patients.

Two hundred and twenty nine cases of breast cancer diagnosed and treated in CMC, Ludhiana were studied for their clinical details, histological features and followed up. Various factors have an effect on the prognosis. The relationship between various clinicopathological features and prognosis were evaluated. The good prognostic factors in this study were middle age, small size of the tumour, low histological grade with marked lymphocytic infiltrate around the tumour, and sinus histiocytosis and no tumour metastasis in axillary lymph nodes. Pregnancy, lactation, younger age, large size, high grade tumour, skin invasion, and increased number of metastatic axillary lymph nodes were associated with significantly poor prognosis.

Adult↗
PubMed1985

Gastric acid secretion in patients with typhoid fever.

Gastric secretory studies were carried out in the following groups of patients: group A, 30 Salmonella typhi positive enteric patients, group B, 15 non-enteric fever patients and group C, 20 healthy controls. Patients with typhoid were divided into two subgroups on the basis of the severity of the disease: group A1 (17) consisted of uncomplicated cases of enteric fever and group A2 (13) comprised of those who had associated complications. During convalescence both groups of typhoid patients showed significantly lower basal acid output (BAO) and maximal acid output (MAO) levels compared with controls and patients with non-enteric fever. Patients in group A2 had significantly lower MAO levels compared with group A1 but the BAO levels showed no such difference. In contrast BAO and MAO levels during convalescence in patients with non-enteric fever were similar to those in the control group. After two months, there was a significant increase in both the BAO and MAO levels in groups A1 and A2. The levels in group A2, however, remained significantly lower compared with group A1, controls and patients with non-enteric fever. Histologically, the gastric mucosa did not show any significant abnormality in either group of typhoid patients. The results suggest that depressed gastric secretion is the result of enteric infection and is related to the severity of the disease process.

Adolescent↗
PubMedDate not supplied

Fine needle aspiration cytology of a dedifferentiated liposarcoma: report of a case with histologic and immunohistochemical follow-up.

BACKGROUND: Dedifferentiation is a histologic progression of a neoplasm from low grade to high grade histology. It occurs in tumors of the retroperitoneum and in those undergoing treatment. This usually occurs in the setting of radiation or chemotherapy or as a spontaneous process over a long period. The features of dedifferentiation can be toward any mesenchymal element of the underlying neoplastic process. CASE: We report the cytologic features of a dedifferentiated liposarcoma arising in a 76-year-old man who had a history of well-differentiated liposarcoma. Papanicolaou- and Diff-Quik-stained smears from a radiologically guided fine needle aspiration biopsy showed a hypercellular sample. The smears showed a mixed population of cells. There were multinucleated, pleomorphic giant cells with abundant cytoplasm, smaller clusters of cells with a high nuclear/cytoplasmic ratio and cells with spindled and elongated nuclear features. The follow-up surgical resection specimen showed a dedifferentiated liposarcoma with strong and diffuse immunoreactivity to vimentin, desmin and CD68 in the large, pleomorphic cells; focal and weak immunoreactivity to smooth muscle actin and S-100 in these cells; and strong and focal immunoreactivity to desmin, smooth muscle actin and muscle-specific actin in the spindle cells. This supports the dedifferentiated components of this tumor to be of fibrohistiocytic and leiomyosarcomatous differentiation. CONCLUSION: Dedifferentiation of a well-differentiated liposarcoma should be entertained in the setting of a mass lesion in the retroperitoneum in patients with prior histories of well-differentiated liposarcoma. The radiologic features of a particular neoplastic process can be very helpful in determining the nature of this process.

Aged↗
PubMedDate not supplied

Leucocytoclastic vasculitis as a presentation of adenocarcinoma rectum.

Vasculitis has been linked to several processes, like infections, drugs and allergic, rheumatologic and neoplastic diseases. Neoplasm-associated vasculitis described in the medical literature has mostly been reported in association with haemotological neoplasms. Adenocarcinoma of rectum presenting as leucocytoclastic vasculitis is rare. We present a case of a 43-year-old male with paraneoplastic leucocytoclastic vasculitis preceding the manifestation of adenocarcinoma rectum. The vasculitis subsided on resection of the rectal malignancy and the patient did not require steroid therapy thereafter.

Adenocarcinoma↗