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Biomedical subjects

S Bernardi

Publications and source records attributed to S Bernardi.

66 records · Page 4Linked to original sources
PubMedDate not supplied

Mucocutaneous manifestations in children with HIV infection and AIDS.

Mucocutaneous diseases are more frequent in HIV/AIDS-infected children than in the normal population. We analyze mucocutaneous disorders with atypical presentations in a large population of HIV-infected children, with or without full-blown AIDS, compared to a population of HIV seroreverted children. The majority of these cutaneous disorders have an infectious etiology and their frequency is related to the degree of deterioration of the immune system. Some diseases commonly observed in adults are rare in children; neoplasms are an exception.

AIDS-Related Opportunistic Infections↗
PubMedDate not supplied

Herpetic whitlow as a harbinger of pediatric HIV-1 infection.

Herpetic whitlow applies to a primary or recurrent herpes simplex infection of the fingers. It is a rare condition in immunocompetent patients, and usually has a rapid evolution and prompt response to treatment. We report a 10-year-old girl referred to our department of infectious diseases with recurrent and unresponsive ulcerated and necrotic lesions of the fingers of both hands as a first sign of human immunodeficiency virus infection. Numerous instances of extensive or recurrent herpes lesions of the mouth, lips, and perianal areas have been found in the literature, but we have not found any report of periungual infection as a first manifestation of human immunodeficiency virus infection. Pediatricians and dermatologists need to be aware of this association in order to make an early diagnosis and start treatment of these patients' disease.

Anemia, Hypochromic↗
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[Social unsuitability in the developmental age. Hypothesis for new structures helping social adjustment].

In this report the Authors analise, according to their different competences, from a psychiatric, psycho-sociological, and of judicial politics point of view, a case of neurosis of conflict during adolescence, with an anti-social development, regarding which it has been ascertained that the measures of restoration, which have been adopted, have failed their purpose. They have, as a matter of fact, paradoxically fixed the subject even more in his anti-social condition, not giving him the possibility of escaping the psycho-pathological destiny of negative sociopatic deviation. The Authors, in this report, reflect upon the meaning of the Institutes of restoration and punishment in the light of the new re-educational conceptions, pointing out their limits. They long for the institution of supplementary structures of little dimensions in the bosom of the family, well integrated with the school, the working milieu, and the local community and wish the structures of restoration for anti-social disadaptations to stop from being static Institutions far from the real social problems of a democratic life, in order to become centers of social democratic life and places of comparison, according to a dialectic method of knowledge, between subculture as deviation (which is not always negative) and the dominating culture with its needs and rules.

Adaptation, Psychological↗
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[Longitudinal comparison of methods of auditory evoked potentials in defined multiple sclerosis].

The object of the present paper was to evaluate the diagnostic accuracy of ABR using ipsilateral masking in patients suffering from multiple sclerosis. Fourteen patients were examined. Each patient with normal audiogram underwent two ABR recording sessions during a follow-up period of thirty months. The ABRs were recorded under two experimental conditions applying standard testing procedures and ipsilateral masking, respectively. In 5 patients magnetic resonance imaging was also available. The findings were compared with a control group, composed of 20 normal subjects. Standard ABR testing gave evidence of a pathological value in 50% of the cases while the ABRs proved to be altered in 64% under ipsilateral masking. The outcomes were less favourable than those obtained with somatosensory or visually evoked potentials. The conclusions drawn confirm the importance of ABR in the follow-up of multiple sclerosis. On the other hand, ipsilateral masking does not appear to provide any significant advantages due to poor amelioration of sensitivity and doubtful specificity of the observed alterations.

Adolescent↗
PubMedDate not supplied

[Extrapyramidal type collateral effects of the administration of metoclopramide to children].

Metoclopramide (M.) is a neurolectic drug used with good results in digestive tracts disorders. Even in minimum doses Metoclopramide may cause side effects to children. The most frequent are: localized hypertonia, oculogyric fits, trismus, cervical, oral and lingual dyskinesias, tremors and agitations. Symptoms seem to be serious but it is sufficient to stop the cure that all signs fade away. Manufactures show three personal side-effects' remarks by M. and advise to administer the drug to children with more caution since they are very sensitive to the substance.

Adolescent↗
PubMedDate not supplied

Amikacin-induced liver toxicity: correlations between biochemical indexes and ultrastructural features in an experimental model.

In previous studies, aminoglycosides (AG) as gentamicin (G), dibekacin (D), tobramycin (T), netilmicin (N) and Sysomicin (S) were proved to induce ultrastructural alterations in the liver of experimental animals. The aim of this studies is to investigate the effect of amikacin (AK) on rabbit liver which is commonly used in infections resistant to other AG; this was done studying both the common blood parameters and ultrastructural changes. The study was accomplished in 24 New-Zealand rabbits, twelve received 20 mg/kg AK every 12 hours for 2 weeks. Thereafter the animals were anesthesized and liver slices were obtained for transmission electron microscopy. As results obvious signs of primary and secondary microcholestasis associated to mitochondrial cristae detachment and phospholipid aggregations were noted; this last finding was less marked when compared to previous studies employing other AG. In the AK treated group, blood tests showed a significant increased in only Blood Urea Nitrogen (BUN) and an insignificant rise in AST levels. Our findings are consistent with an AK induced liver toxicity albeit less evident with respect to the other AG.

Amikacin↗
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[Ultrastructural study of the liver in rabbits treated with diclofenac].

The existence of alterations of common indexes of hepatic function, and the case-reports of acute hepatitis after the use of diclofenac sodium are the rationale for this experimental study, in which 8 rabbits were given 15 mg/kg day of diclofenac, to check ultrastructural modifications with respect to a control group. The analysis showed the typical signs of primary and secondary microcholestasis, indicating the existence of liver distress. This finding, from a clinical standpoint, suggests caution in the administration of this drug, chiefly in the hepatopathic patients.

Animals↗
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Evolution and severity markers in 233 MS patients.

Clinical data of 233 patients (202 definite and 31 probable MS) have been examined in relation to the following prognostic indicators: sex, age at onset, poussè frequency, interval between the first two relapses, initial symptomatology. Regression analysis technique and covariate analysis have been used versus the latest Expanded Disability Status Scale of each patients. Onset at younger age and a longer interval between the first two episodes have resulted statistically significant for a more favourable prognosis. The shift from a remitting toward a progressive course appears to happen within the first five years in 60% of the cases.

Adult↗
PubMedDate not supplied

The combined use of radionuclide angiography and Doppler-sonography in the screening of carotid lesions.

The aim of our research is to check if the combined use of radionuclide angiography and Doppler-sonography leads to correct screening of carotid lesions in the neck, independently from the indexes of reliability of the individual examinations. 125 cerebrovascular patients (for a total of 250 carotid studies) were investigated with radionuclide angiography and Doppler-sonography. 100 of these carotids were also angiographically investigated. On the basis combined angioscintigraphic and Doppler results, these patients have been classified in four groups. When both non-invasive examinations result negative, the angiography shows pathological arteries only in 22% of cases. When only radionuclide angiography is positive, the angiography shows pathological findings in 63% of cases: when only Doppler is positive, the angiography confirmation occurs in 72% of cases. Finally, when both non-invasive tests results positive, there is always arterial pathology in the angiography.

Adult↗
PubMedDate not supplied

Bcl-2 oncoprotein expression in acute myeloid leukemia.

BACKGROUND: In lymphoproliferative diseases the expression of Bcl-2, a mitochondrial oncoprotein capable of blocking apoptosis, is well-documented, while little research has been carried out on its distribution in myeloproliferative conditions. METHODS: Using immunocytochemical methods, 63 cases of acute myeloid leukemia (AML) at onset and 10 relapses were studied to investigate Bcl-2 expression and any possible correlations with subtypes of the FAB classification, sex, age or white cell peripheral blood count at onset. RESULTS: Bcl-2 is present in 87.3% of AML cases at onset and in 100% of relapses. In 68.3% of cases at onset and in 90% of relapses the protein is present in more than 20% of the blasts. Relapses always show higher percentages of positive expression than those seen at onset. Our results demonstrate no statistical correlations between the expression of the oncoprotein Bcl-2 and FAB subtypes, sex, age, or white cell peripheral blood count. CONCLUSIONS: The majority of blasts from AML patients express the oncoprotein Bcl-2, which is able to protect leukemic cells from apoptosis. Since numerous chemotherapies are cytotoxic in that they induce apoptosis, we feel that in vitro studies of cells from AML patients are necessary in order to broaden our knowledge about the effects of the most common therapeutic drugs and of those substances which, alone or in association, can modulate Bcl-2 expression.

Acute Disease↗