Biomedical subjects
Publications and source records attributed to S Baux.
Paclitaxel is a new antimitotic derived from yew-tree, used for the treatment of ovarian and breast cancers. The local toxicity of paclitaxel is still poorly known. We report one of the first observations of accidental subcutaneous extravastion of paclitaxel. Local epidermic necrosis was observed and evolution was good with local treatment only. Treatments of such extravasation are discussed.
The effect of a vasodilator (naftidrofuryl) was evaluated in an experimental study in rats concerning the viability of a skin flap. The reference flap is a dorsal skin flap deliberately shaped very long in order to obtain necrosis of its distal extremity. This necrosis is measurable and sufficiently reproducible. Using a comparative study between a control group of ten rats and a group of rats treated by intraperitoneal injections of naftidrofuryl for ten days, the authors demonstrated a significant difference between necrosis in the two groups. Naftidrofuryl treatment increases the length of the viable part of the skin flap in rats. This product achieves a kind of medicinal autonomy much easier than a surgical autonomy.
The authors report an exceptional case of retrolunate dislocation of the carpus associated with a Schernberg type III scaphoid fracture and a transverse fracture of the triquetrum at the level of its median crest, avulsing all of the upper third of this bone. That describe the emergency treatment and the radiological and operative findings.
The authors report the first case in the literature of a chronic injury of the medial scaphotrapezial ligament. The main clinical feature was elective pain over the lateral margin of the carpal tunnel which was increased with effort. The pain was disabling and complete remission is obtained after surgical repair of the ligament.
Study of 25 forearms of fresh cadavers, whose the arteries have been injected with colored latex. The posterior interosseous artery is known for its superficial branches, which allow to autonomise cutaneous dorsal flaps. Its way, along the ulna allows to imagine other possibilities by use of the constant branches of this artery, which supplies the proximal and the distal extremities of the bone. The proximal branch is the posterior recurrent radial artery, which supplies the posterolateral face of the proximal pars of the diaphysis, in touch of the insertions of the supinator muscle, and the lateral edge of the olecranon. The distal arteries shape 2 or 3 fascicles, which disperse on the extremity of the diaphysis and the cervical pars of the ulna. To realize a vascular pedicle with the posterior interosseous artery, two cases can be envisaged: use of the distal ulnar epiphysis and creating of a direct pedicle. use of the proximal ulnar epiphysis and creating of a recurrent pedicle.
The authors have performed 20 systematical dissections of the distal part of the foot, conserved in the Toulon's liquor and 3 dissections of fresh cadavers. The last ones have been submitted at different puttings in charge before and after the resection of the intermetatarsal transverse ligament. The intermetatarsal transverse ligament is supple, extensible, but very strong. It constitutes the area of convergence of all the neighbouring fibrous structures and of several tendons of the foot. It connects together the heads of the metatarsus. It renders them jointly liable and its action is reflected above. By its modulating of the convergence of the metatarsus and their necessary associated palmar inclination, by its limitation of their divergence in relation with their dorsal inclination, it modulates and it limits the amplitude of the tarsometatarsal joints. It is helped for that by the little intermetatarsal transverse ligaments, whose the presence has been always confirmed. The metatarsus varus, very frequently associated with the hall valgus, means the escape of the first ray from the effect of the transverse intermetatarsal ligament.
The volar fascicles of the interosseous muscles possess two separate components: the proximal and glenoidal one, the distal and aponeurotic other. The armature of the dorsal aponeurosis is constituted the deep, the central and the collateral expansions of the extensor digitorum muscles, and the interosseous muscles, whom are added the lumbrical muscles. The deep expansions are constant and are fixed respectively at the basis of the first phalanx. The central and the collateral expansions constitute equally the central and the collateral, then terminal tendons, which are respectively fixed at the basis of the second and at the third phalanx. The unitive structures: dossiere, triangular and retinacular ligaments are intricate with this of the armature and render jointly the whole. All the concerned fascicles have the mechanical and histological characteristics of the tendon.
The putting in tension of the dorsal aponeurosis of the digits induces its retraction and the nearness of its insertions on the basis of the 3 phalanges. It depends on the extensor digitorum, interosseous and lumbrical muscles. The aponeurosis is not a single driving belt, but set off in itself 3 types of reaction: 1) The gliding on the sides of the pyramid, which constitute the proximal epiphyses of the phalanges. It suppresses the central dorsal-ward tensions. 2) The displacement of the axes of insertion and rotation of retinacular ligaments inducing collateral volar-ward tractions. 3) The modifications of the way of the structures of transmission: at one time the lengthening of the way is induced by the interactions of the fibers; at other times a shortening is suppressed by the extension of the close proximal joint. Analysis of the different fibrous and fascicular interactions and translations.
The physiopathology of the main deformities of the fingers, induced by the injury of the dorsal aponeurosis of the fingers, is caused by an imbalance of forces: proximally between extrinsic and intrinsic muscles; distally between central and collateral structures. The ulna Claw, caused by the whole paralysis of the intrinsic muscles, can be corrected by an interosseous tenodesis on the basis of the finger. The boutoniere is induced by the exaggeration of the action of the collateral structures with respect to this of the central structures. The swan neck is induced by the exaggeration of action of the central structures with respect to this of the collateral structures. The surgical treatment consist to give back those structures their normal lengthening and way, or else to create new detours or shortenings, allowing to give back the balance. So, any structures, spared by the traumatism, will not injure by the surgeon.
Ligamentous lesions were created experimentally in 40 fresh cadaver wrists. The precise localization of traumatic rupture of the ligaments and the subsequent carpal imbalance were defined by the comparison between the experimental results and the clinical displacements. The displacements may be permanent, sequential or induced by external forces. Lesions of capsular ligaments cause the displacement. There are 3 functional units; the distal scaphoid complex; the palmar ligaments which form a "belt", consisting of the lateral external ligament, the radiocarpal ligaments an the radiate ligament; the medial ligaments, which also form a "belt" consisting of the palmar triquetral ligaments on each side of the triquetrum. The sprains are caused by a lesion of a functional unit. The lateral sprain is characterized by a lesion of the distal scaphoid complex. The scaphoid moves into a horizontal position, causing a dorsal deviation of the lunate and a scapholunate diastasis. The central sprain is induced by a rupture of the palmar "belt", causing an anteroposterior radiocarpal or mediocarpal drawer movement. The medial sprain is induced by the rupture, of different extents, of the medial ligaments. On examination, there is either a click or a palmar deviation of the lunate, sometimes with a lunotriquetral diastasis. The dislocations of the wrist are caused by lesion of several ligamentous units.
The synovial sheaths of the flexor digitorum of 70 pieces of fresh cadavers have been studied on the whole of their length as far as the basis of the fingers: 20 have been injected with a latex or a physiologic solution, after the ablation of the palmar aponeurosis and of the superficial palmar arch. The arteries of the 50 other pieces have been injected with coloured latex solution from humeral artery. The proximal limit of the superficial sheaths is located 5 centimetres above the radiocarpal articular line and this of the deep sheaths 7 centimetres. In the metacarpal area, the superficialis central sheath presents peritendinous expansions, which realise an uninterrupted connection with each digital sheath. It is the aponeurotic and vascular extrinsic compressions, which simulate the interruption of these expansions. The proximal synovial arteries have a muscular origin. The antibrachial collateral arteries, 3 pairs in number, arise from the radial and the ulnar arteries. The distal synovial arteries come from the palmar arches and from their branches: superficial branches for the superficial sheaths and deep branches for the deep sheaths. There is many anastomoses between the different synovial arteries. Two are particularly developed and connect the proximal arteries to the palmar arches: the superficial longitudinal anastomotic artery; which runs close along the medial edge of the median nerve; the deep longitudinal anastomotic artery, which gives the nutritious branches for the tendons of the flexor digitorum. This disposition allows to create two synovial flaps of gliding and vascular help, centred on the anastomotic longitudinal arteries, pediculated on the volar archs and distal-ward rotated.(ABSTRACT TRUNCATED AT 250 WORDS)
Recapitulation of the principal stages concerning the descriptive and the functional anatomy of the extensor apparatus of the ulnar digits. They can be written in the following frame: The Gálien's theories of the exclusive role of the extensor digitorum muscles prevail during more as a millenium. The indispensable conjoined action of the interosseus muscles through the collateral tendon is demonstrated by Duchene in 1867. The role of antagonistic muscles is clearly showed by Bouvier in 1851 on the level of the metacarpo-phalangeal joints and by Valentin and Tubiana in 1962 on the level of the proximal interphalangeal joints. The role of the oblique retinacular ligament on the extension of the third phalanx is specified in 1956 by Landsmeer.
The study of the extensor apparatus through different methods concerns 200 fingers, the most of fresh cadavers. The dissection through direct observation or with surgical microscope of the dorsal aponeurosis of 30 fingers has been completed by an histological study of 10 fingers. The mechanic properties of each dorsal aponeurotic structure has been tested by extensometry on 12 fingers. The functional study of the role and of the transmission of the different motor components concerns 128 fingers. It has been completed by experimental sections of each aponeurotic structure concerning 20 fingers.
A case of posttraumatic carpal dislocation in volar inclination of the intermediary segment (VISI), treated by a lunate-triquetrum-hamate arthrodesis (LTH) is presented. This operation leaves the rupture of the radio-triquetrum dorsal ligament; rather the entire carpus rotates in supination postoperatively. This repair of the radio-triquetrum dorsal ligament permits realignment and stabilization of the carpus and results in resolution of pain.
Bony lesions were created experimentally in 48 fresh cadaver wrists. They consisted of radial and scaphoid resections along the extent of the proximal carpal row, representative of clinically-induced (usually traumatic) lesions. The displacements obtained experimentally to mirror each clinical situation modify the physiologic equilibrium established between the trans-osseous forces and the ligaments. The comparison between the experimentally-induced lesions and clinical displacements shows the etiology of the clinical conditions which indicates the proper treatment.
Every fibrous structure of ten wrists of fresh cadavers has been the object of an elastometric study. The opposite wrists have been studied surgically and then histologically with the optical microscope. Comparison between the two shows a close relationship between the mechanical features and the morphology of the bundles, which proved also to be perfectly measurable. It also displays the great differences between ligaments and tendons. Histological study of the tendons and ligaments of four other wrists subjected to manoeuvres of axial loading, rupture and bending, reinforces these statements. The therapeutic consequences are considered.
The authors, after recalling the technique of Iridium 192* brachytherapy in the treatment of keloid scars, report a series of 46 cases operated at Rothschild Hospital (Department of Professor Baux) and irradiated at Tenon Hospital (Department of Professor Laugier), between 1981 and 1987. 87% of results were considered to be satisfactory.