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Biomedical subjects

S Bassily

Publications and source records attributed to S Bassily.

At least 37 records · Page 2Linked to original sources
PubMed1987

Circulating immune complex levels in patients with schistosomiasis and complications.

Circulating immune complexes (CIC), adult schistosome antibody, and total immunoglobulin concentrations were estimated in sera from 35 chronic Schistosoma mansoni patients with different infection intensities and different pathological complications. High CIC levels were present in about one-third (10/35) of the sera. Most of the patients (9/10) with elevated CIC levels also had hepatomegaly or hepatosplenomegaly. This finding is significant in the pathogenesis of schistosomal liver fibrosis and may also apply to other liver diseases, especially cirrhosis. No correlation was found between infection intensity as judged by stool egg counts and CIC levels. A reverse relationship was observed between the level of anti-adult worm IgG and CIC levels. CIC levels were elevated within 7 and 28 days after treatment in most patients. Hypergammaglobulinaemia was detected in most sera.

Adolescent↗
PubMed1987

Immunogenicity of hepatitis B vaccine in patients infected with Schistosoma mansoni.

Because dual infection with Schistosoma mansoni and hepatitis B may lead to severe liver disease, populations living in schistosomiasis-endemic areas might benefit if effectively immunized against hepatitis B. To determine whether a plasma-derived hepatitis B vaccine is immunogenic in patients with schistosomiasis, 32 individuals infected with S. mansoni were given three 20-micrograms doses of Heptavax-B vaccine and treated with praziquantel. Antibody to hepatitis B surface antigen developed in 90.6% of the study subjects after three doses of vaccine. Five patients (15.6%) had a weak response to the vaccine, and three patients (9.4%) failed to develop antibody. A weak or failed response to the vaccine was significantly associated with the presence of hepatosplenomegaly. A plasma-derived vaccine is immunogenic for persons infected with S. mansoni; however, vaccine response is diminished in hepatosplenic schistosomiasis.

Adolescent↗
PubMed1987

Treatment of intestinal E. histolytica and G. lamblia with metronidazole, tinidazole and ornidazole: a comparative study.

Metronidazole, tinidazole and ornidazole were compared in patients treated for Entamoeba histolytica or Giardia lamblia intestinal infections. Only patients with three positive stool specimens for trophozoites and/or cysts of E. histolytica or G. lamblia by the merthiolate iodine formaldehyde (MIFC) technique were included. Criteria for cure were at least 10 negative stool specimens over 3 weeks after completing therapy. Fifty-three male patients (aged 9-65 years) had E. histolytica infection. Seventeen received metronidazole (1.5 g daily for 10 days), 18 tinidazole (1.5 g daily for 10 days) and 18 ornidazole (1 g daily for 10 days). Metronidazole yielded 88%, tinidazole 67% and ornidazole 94% cure rates. Side reactions were minor. Eighty patients had G. lamblia infection, of whom 20 received metronidazole (0.5 g daily for 10 days), 30 tinidazole (single 2 g dose) and 30 ornidazole (single 1 g dose). Cure rates were 95% for metronidazole, 90% for tinidazole and 97% for ornidazole with no side reactions.

Clinical Trials as Topic↗
PubMed1986

Acute sporadic hepatitis in adults living in Cairo, Egypt.

A group of 295 adult male patients from Cairo, Egypt, with acute hepatitis were studied. Acute hepatitis A was diagnosed in 8 patients (2.7%), hepatitis B in 115 (38.9%), delta infection in 19 (6.4%) and possible Epstein-Barr virus or cytomegalovirus-mediated hepatitis in 7 patients (2.4%). The remaining 146 patients (49.5%) were considered to have hepatitis non-A non-B. The clinical presentation of the various causes of hepatitis was similar, although patients with hepatitis B and delta infection had significantly higher mean alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels than patients diagnosed as having hepatitis non-A non-B. Various risk factors for the acquisition of hepatitis were evaluated. A history of an injection for medical treatment and a history of anti-schistosomal therapy were significantly associated with delta infection when compared to patients with either hepatitis B or non-A non-B (P less than 0.05). Hepatitis non-A non-B is a major cause of acute hepatitis in adults living in Cairo, and an iatrogenic source of infection may be important in the epidemiology of delta infection.

Acute Disease↗
PubMed1986

Schistosomal colonic polyposis: clinical, radiological and parasitological study.

One hundred and eight male Egyptian farmers with schistosomal colonic polyposis were reviewed. All patients gave a history of bloody diarrhoea. Sixty-one patients presented with finger clubbing, and four of these patients had painful, tender and swollen wrist, knee and ankle joints. X-ray revealed new bone formation in the bones around these joints. The clinical condition improved with antischistosomal treatment, but the bony changes persisted. Twenty patients showed signs of dependent oedema or ascites. Thirty-one patients had a liver of 8 cm or more below costal margin and 19 patients had a spleen of 8 cm or more below costal margin, a situation not unlike patients with schistosomiasis without polyposis. Fifteen patients had tender abdominal masses in the left iliac fossa which were shown by barium enemas to be clusters of polyps. Anti-schistosomal therapy relieved the obstruction but narrowing persisted in 70% of patients followed up. Severity of schistosomal colonic polyposis correlated with the anatomical distribution of the polyps, with their number and with the egg excretion rates.

Adolescent↗
PubMed1986

Oxamniquine treatment for schistosomal polyposis: a 1-2 year follow-up study.

A follow-up was carried out into the study of schistosomal colonic polyposis reported in the last article. Eighteen patients with schistosomal colonic polyposis were treated with oxamniquine and their progress was evaluated for 2-3 weeks after treatment, at 3 months and at 12-24 months. Sigmoidoscopy to examine mucosa on the polyps and barium enemata to determine the size and number of polyps showed variable success, but treatment with oxamniquine produced no untoward side effects.

Adolescent↗
PubMed1985

Praziquantel for treatment of schistosomiasis in patients with advanced hepatosplenomegaly.

We evaluated praziquantel for therapy of active Schistosoma mansoni infection in 15 rural Egyptian males with hepatosplenic schistosomiasis. Criteria for inclusion in this study were two pre-treatment S. mansoni egg counts with a mean of greater than 100 eggs g-1 faeces and an enlarged spleen. Fourteen of 15 patients had hepatomegaly, five had ascites, and six had serum albumin below 3 g dl-1. Schistosoma haematobium infection (less than 10 eggs ml-1 urine) was present in three patients. Praziquantel was administered in a single oral dose of 30 mg kg-1 body weight. Eight of the 15 patients (53%) had mild and transient reactions in the form of fever (usually one day), gastrointestinal symptoms, headache and skin rash. Criteria for parasitological cure were the absence of live eggs in two stool samples and a negative rectal snip biopsy three months after therapy. Ten patients ceased to pass live eggs (cure rate 67%). For the five who were still passing live eggs there was a mean egg reduction of 95%. The three patients with S. haematobium demonstrated parasitological cures. We conclude that praziquantel is an effective and well tolerated drug for treatment of S. mansoni infection in patients with advanced hepatosplenic schistosomiasis, and it is the drug of choice for patients with coexisting S. haematobium infection.

Adolescent↗
PubMed1983

Acute hepatitis non-A non-B in Cairo residents (a preliminary report).

Of 110 patients admitted with jaundice to the Abbassia Fever Hospital (AFH) in Cairo, 49 had acute hepatitis A infection (positive for anti-hepatitis A specific IgM), 28 had hepatitis B infection (positive for HBsAg) and seven had both markers. Of great interest, however, was the finding that 26 patients had no markers for either A or B virus infection. Clinically and biochemically, the non-A non-B hepatitis group resembled the other two infections. None of the 26 patients lacking both markers gave a history of previous blood transfusion or parenteral injections. Thus, the possibility of a faecal-oral or water-borne infection must be considered in these cases.

Adult↗
PubMed1983

Chronic hepatitis B in patients with schistosomiasis mansoni.

A village, 20 miles north of Cairo, with a census population of 2010, was surveyed in 1976 by the Center of Disease Control (CDC) and the Egyptian Ministry of Health for hepatitis B surface antigen (HBsAg). Ninety individuals (47 males and 43 females were positive for HBsAg (a prevalence rate of 4.5%). Forty-two of the 47 males were the subject of this study. They were admitted to the Naval Medical Research Unit Hospital 2 years later. They all had active Schistosoma mansoni infection. Nineteen of the 42 were carrying HBsAg and the remaining 23 were negative for hepatitis antigen at this time of investigation. Histological examination of percutaneous liver biopsies showed chronic-active hepatitis in five of 17 HBsAg carriers including two with additional cirrhosis. Two others with clinical evidence of cirrhosis could not safely have biopsies taken. Two of these 19 persons died and three became incapacitated over 2 years of further observation. Of the 23 individuals who had transient HBsAg in 1976 and equally heavy S. mansoni infection, evaluation in 1978 showed chronic active hepatitis in one, and at re-evaluation 2 years later, one had become unable to work but none had died. Ten other individuals (military recruits) from different villages of the Nile Valley who had no schistosomiasis but were carriers of HBsAg, were symptom free and liver biopsy showed chronic active hepatitis in one individual and no morbidity or mortality in 2 years. Morbidity of chronic hepatitis B infection in S. mansoni infected persons appears to be unusually severe compared with hepatitis B infection in other populations.

Adolescent↗