Biomedical subjects
Publications and source records attributed to S Barsky.
A 43-year-old man with a crusted papule on the cheek was found to have a squamous cell carcinoma of the lung. Histologic examination of the skin lesion showed the characteristic features of warty dyskeratoma. A rare clinical photograph is presented and the clinical and histopathologic features are reviewed.
Four patients with nevus comedonicus (NC) and the histological changes of epidermolytic hyperkeratosis (EH) are described. The relationship between NC and other epidermal nevi in which EH may occur is further emphasized by this finding.
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Two case reports of lichen striatus with nail dystrophy are presented herein. Review of the literature suggests a more protracted course for the cutaneous eruption if there is nail involvement. Biopsy is important to differentiate this condition from other linear lesions that may interfere with normal nail growth.
Although acquired ichthyosis may appear in patients with various systemic illnesses, an association with with sarcoidosis has rarely been reported. However, three adults who presented with sarcoidosis and ichthyosiform changes on their legs are discussed herein.
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Our case of cutaneous leishmaniasis clinically resembles the atypical form "infiltrees en nappes" that was described by Photinos in 1930. A subsequent biopsy of the lesion was performed more than one year after its onset and after a full course of stibogluconate sodium and the specimen showed multiple organisms in multinucleated giant cells as well as in histiocytes. Electrodesiccation and curettage of the lesion resulted in complete healing with minimal scarring.
To our knowledge, this communication reports the first case of Trichophyton simii infection in the United States not traceable to India, The patient was a 40-year-old Nigerian male student who had not been out of the United States for more than three years. He had never been in India or had contact with animals or poultry. A brief review of the literature is included.
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The relative efficacy of fluocinonide and betamethasone benzoate gels in treating the symptoms of psoriasis was evaluated in 335 patients, of whom 263 were analyzable. By means of a paired comparison design in which both drugs were examined simultaneously in the same patient, many potential sources of variation were eliminated. In addition, the analysis took into account the difficulties of pooling results in a multicenter trial. Imposing a rigorous grouping structure on the results from individual clinics minimized differences between clinics and demonstrated consistently high, statistically significant results in favor of fluocinodine gel even when several different statistical approaches were used. Local adverse reactions related to drugs were experienced by few patients.
Desonide, a nonfluorinated topical corticosteriod, was compared with fluocinonide, a potent fluorinated steroid, in identical concentrations, in the treatment of various steroid-responsive dermatologic disorders. In treatment comparisons, the group treated with desonide showed significantly (p less than 0.05) better erythema and scaling scores after the first week than did those in the fluocinonide group, but the two week scores were not significantly different. Although 5 percent of patients treated with fluocinonide had adverse reactions, no such reactions were observed in the desonide-treated group.
Umbilical endometrioma is an uncommon entity and is rarely asymptomatic. A 24-year old black woman had an asymptomatic, spontaneous umbilical endometrioma. The lesion was excised and the diagnosis was histologically confirmed.