A clinical trial of bupropion in the treatment of depressed outpatients.
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Biomedical subjects
Publications and source records attributed to S Barnett.
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In two groups of patients, noncompliance with drug regimens resulted in misinterpretation of serum theophylline levels. All six chronic asthmatics in the first group, found in a retrospective review of 43 outpatient charts, had outpatient serum theophylline levels in the therapeutic range (10 to 20 microgram/mL) and at least a 7-microgram/mL greater inpatient theophylline level while receiving the same dosage. When hospitalized, four of these patients had serum theophylline levels in the toxic range (greater than 20 microgram/mL). In the second group four hospitalized patients had persistently low serum theophylline levels despite an adequate theophylline dose. When compliance was enforced, serum theophylline levels rose significantly. Compliance cannot be assumed in the outpatient with a serum theophylline level in the therapeutic range or in the hospitalized patient. Determination of serum theophylline level after supervised drug administration is recommended in inpatients requiring unusually high doses of theophylline or in those whose condition is poorly controlled despite having serum theophylline levels in the therapeutic range (10 to 20 microgram/mL).
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OBJECTIVE: To examine the association between age at onset of deafness and mortality. METHODS: The authors analyzed National Health Interview Survey data from 1990 and 1991--the years the Hearing Supplement was administered--linked with National Death Index data for 1990-1995. Adjusting for sociodemographic variables and health status, the authors compared the mortality of three groups of adults ages > or = 19 years: those with prelingual onset of deafness (< or = age 3 years), those with postlingual onset of deafness (> age 3 years), and a representative sample of the general population. RESULTS: Multivariate analyses adjusted for sociodemographics and stratified by age found that adults with postlingual onset of deafness were more likely to die in the given time frames than non-deaf adults. However, when analyses were also adjusted for health status, there was no difference between adults with postlingual onset of deafness and a control group of non-deaf adults. No differences in mortality were found between adults with prelingual onset of deafness and non-deaf adults. CONCLUSIONS: Adults with postlingual onset of deafness appear to have higher mortality than non-deaf adults, which may be attributable to their lower self-reported health status.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
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Client satisfaction and pregnancy outcomes of two groups of low socioeconomic women were compared. One group received prenatal care from a public health clinic, the other from a prototype tertiary multidisciplinary clinic. Sixty-two women from each clinic completed the Risser Patient Satisfaction instrument, after no less than three clinic visits. Clients from the multidisciplinary clinic were significantly more satisfied on three variables related to nursing care (technical skills, teaching, and interpersonal relationships), and one variable related to setting. Postdelivery log reviews revealed that infant birth weights, Apgar scores, and gestational ages were not significantly different between the two groups. Nurse case managed care and removal of barriers contributed to more satisfied consumers. Continuity of prenatal care was associated with healthy infants regardless of client perceptions of satisfaction.