Search PubMed⌕ Search

Biomedical subjects

S Bar-Meir

Publications and source records attributed to S Bar-Meir.

At least 91 records · Page 5Linked to original sources
PubMed1985

Effect of (+)-cyanidanol-3 on chronic active hepatitis: a double blind controlled trial.

Forty patients with biopsy proven chronic active hepatitis were studied, 22 received (+)-cyanidanol-3 in a dose of 3 g daily and 18 placebo. Side effects related to cyanidanol were fever (four patients), haemolysis (one patient) and urticaria (one patient). All side effects subsided on discontinuation of the medication. Cyanidanol had an effect no better than placebo on symptoms, laboratory tests, and histological findings on liver biopsy.

Benzopyrans↗
PubMed1984

Failure of balloon membranotomy of the inferior vena cava.

A young woman with membranous obstruction and coarctation of the inferior vena cava is described. A balloon membranotomy was performed with a transient improvement. Three months later massive thrombosis of the inferior vena cava developed. It appears that balloon membranotomy alone is contraindicated in the presence of both stenosis and membranous obstruction of the inferior vena cava.

Adult↗
PubMed1984

The significance of the diameter of the common bile duct in cholecystectomized patients.

In the cholecystectomized patients there is no correlation between the diameter of the common bile duct and the pressure in the biliary system or in the sphincter of Oddi. It is most probably due to unresolved dilatation of the common bile duct. ERCP manometry is probably a more accurate technique for establishing the diagnosis of papillary stenosis in patients who had their gallbladder removed.

Cholangiopancreatography, Endoscopic Retrograde↗
PubMed1983

Endoscopic removal of a giant duodenal polyp.

A 50-year-old female with a giant duodenal polyp is described. An uneventful endoscopic removal of the polyp was performed. An aggressive endoscopic approach to such tumors seems to be justified regardless of their size.

Adenoma↗
PubMed1983

Nitrate therapy in a patient with papillary dysfunction.

A 64-yr-old woman with ERCP manometry proven papillary dysfunction is described. This patient responded to nitrate therapy with disappearance of the pain and decrease in both basal and phasic sphincter activity. It is suggested that nitrate administration should be used to distinguish between patients with functional and organic pathology of the sphincter of Oddi. Nitrate therapy should be tried in patients with papillary dysfunction and only if this fails, should endoscopic sphincterotomy be considered.

Ampulla of Vater↗
PubMed1983

An increased familial frequency of gallstones.

Despite the very high prevalence of gallstone disease, studies of familial factors are very few, and asymptomatic family members were not studied. We studied, in a prospective manner, the frequency of gallstones in 171 first-degree relatives of patients with proven gallstones compared with 200 matched controls. All subjects were studied by oral cholecystography, and their height, weight, blood glucose, cholesterol, and other parameters were measured. Gallstones were found in 20.5% of the family group and in 9.0% of the control group. Gallstones were found in 22.8% of the female and 16.7% of the male family members as opposed to 10.3% of the female and 8.0% of the male controls. All these differences were statistically significant. Known risk factors, such as Ashkenazi community group, higher age, and overweight, were more frequent in the control group, as were blood glucose and cholesterol. These findings strengthen the validity of the twofold higher frequency of gallstones found in the family group and are likely to be due to genetic factors. A formal genetic family study of gallstone disease is now indicated, using the ultrasonic method.

Adult↗
PubMed1983

99mTc-HIDA cholescintigraphy in children with Dubin-Johnson syndrome.

Tc-HIDA cholescintigraphy in Dubin-Johnson syndrome (DJS) demonstrates intense prolonged homogeneous visualization of the liver, together with delayed visualization of the gall bladder and extrahepatic ducts. Such a cholescintigram has not been described for any other hyperbilirubinemic state. Because it is a noninvasive and easy technique, it is recommended for the evaluation of children suspected of having DJS.

Bile Ducts↗
PubMed1982

99mTc-HIDA cholescintigraphy in Dubin-Johnson and Rotor syndromes.

99mTc-HIDA cholescintigraphy was performed in 6 patients with Dubin-Johnson syndrome and 1 patient with Rotor syndrome. In the patients with Dubin-Johnson syndrome, the cholescintigrams had a characteristic pattern of delayed visualization or nonvisualization of the gallbladder and bile ducts in the presence of intense, homogeneous, and prolonged visualization of the liver. In the patient with Rotor syndrome, the hepatobiliary system was not visualized at all. It is concluded that 99mTc-HIDA cholescintigraphy may be helpful in the diagnosis of Dubin-Johnson syndrome and Rotor syndrome and in the differential diagnosis between these two conditions.

Diagnosis, Differential↗
PubMed1982

Typhoid hepatitis with immunoglobulins and complement deposits in bile canaliculi.

Documented typhoid fever in a 26-year-old patient was complicated by acute hepatitis with unusually profound jaundice. Liver biopsy revealed focal cell necrosis, mononuclear cell infiltration. Kupffer cell proliferation, and mild cholestasis. Immunofluorescent studies of the liver biopsy revealed deposits of IgG, IgA, IgM, and C3 in the bile canaliculi, suggesting a role for damage by immune complexes in typhoid hepatitis.

Adult↗
PubMed1982

Impairment of bromosulfophthalein clearance by bile salt administration in normal volunteers and patients with Dubin-Johnson syndrome.

Sodium dehydrocholate administration significantly impaired bromosulfophthalein (BSP) clearance in six normal volunteers, despite its choleretic effect. In order to determine whether the impairment is at the stage of excretion of BSP from the liver cell into the bile, patients with Dubin-Johnson syndrome were studied. In all six Dubin-Johnson patients, sodium dehydrocholate administration significantly decreased BSP clearance. Since serum bile acid levels are normal in Dubin-Johnson patients, presumably due to a final secretory pathway into the bile distinct from that of BSP and other organic anions, the interaction between BSP and bile acids cannot take place at the stage of excretion into the bile. Based on a previous study and our results, the interaction between BSP and bile salts seems to occur at the site of transport within the liver cell. This mechanism of inhibition may be responsible for the increased serum BSP retention during chemotherapy.

Adult↗