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Biomedical subjects

S Bala

Publications and source records attributed to S Bala.

At least 55 records · Page 3Linked to original sources
PubMed1983

Organicity and mental retardation: organic mental syndrome battery.

Fifteen mentally retarded children were tested and compared to 10 normal school children. They were administered a battery of tests reflecting organic brain disease, consisting of the Face-Hand, Midline Crossing and Independent Eye Movements Tests. Normals performed correctly 98% of the time on the three combined tests, while the mentally retarded scored only 34% correct. There was a significant correlation between IQ and this battery of tests (the 'OMSB'). When the IQ and OMSB were conflicting, a repeat of the former indicated that the IQ value was erroneous. The OMSB may be useful along with IQ testing as a rapid screening method to evaluate the presence of organicity and its severity.

Adolescent↗
PubMed1981

Organicity and mental retardation: analysis of eye and head movements.

Eye and head movements of ten mentally retarded (MR) children and ten normal school children were recorded. Each was directed to look to one side or the other in response to verbal commands, to gestural directions, or to the appearance of illuminated fixation targets. Under these conditions: 1. Large gaze movements of MR subjects were accompanied by head movements more frequently than those of the normal subjects. Furthermore, for similar gaze deviations, head movement of MR subjects tended to be larger than those of normal subjects. 2. Head movements of normal subjects rarely began before eye movement, but those of MR subjects often did so. This "abnormal" MR eye-head movement pattern was more frequent in response to verbal or gestural commands than in response elicited by illumination of fixation targets.

Child↗
PubMed1980

Partial supplementation with expressed breast-milk for prevention of infection in low-birth-weight infants.

In a prospective controlled study the anti-infective properties of breast-milk were evaluated in 70 high-risk low-birth-weight infants. 32 babies (group I) were given fresh expressed breast-milk during the day and milk formula at night. 38 infants (group II) received only milk formula and served as controls. The two groups were matched for other factors that could influence the occurrence of infection. The incidence of infections was significantly less (p < 0.01) in babies who received breast-milk.

Bacterial Infections↗
PubMed1980

Immunodiagnosis of human filariasis by counterimmunoelectrophoresis using Litomosoides carinii antigens.

The presence of precipitin antibody and soluble circulating antigen was demonstrated in sera of individuals with clinical filariasis by counterimmunoelectrophoresis. Antigens derived from Litomosoides carinii and antisera raised in rabbits to the adult worm antigens were used for the detection of antibody and antigen in human sera. Of 35 subjects, 2 had microfilariae in the peripheral blood, 9 soluble circulating antigen, 19 antibody in sera, and 6 had both antigen and antibody. It suggests that 5.7% of cases diagnosed as bancroftian filariasis by parasitological examination can be increased to 62.8% by serological means.

Adolescent↗
PubMed1977

Population and family studies to demonstrate Ir genes: HLA haplotype in atopic allergy.

47 normal healthy controls and 45 atopic individuals together with five families with allergic diathesis and sensitive to mite antigen were typed for 13 HLA antigens. In general population, HLA-A1 and HLA-A8 were found to be higher than in normal controls. But the difference was significant at a level of p 0.05 after correction was made for the number of HLA antigens used. In one family, an HLA-A1 -B8 haplotype seems to be linked to the manifestation of atopic disease. The pattern of association of an HLA-A9 -B7 haplotype with the disease process in another family indicates that multiple genes may be involved in the manifestation of a variety of allergic disorders. Although more than one HLA haplotype of HLA-associated Ir gene for one antigen have been postulated, we still do not have enough evidence to suggest linkage between HLA haplotypes and atopic allergy. Further studies utilizing mixed lymphocyte culture and carefully matched control with a large number of subjects and more families are in progress to study the genetic basis of allergic diseases.

Asthma↗
PubMed1976

Effect of topical application of medicinal grade petrolatum on various species of laboratory animals and man.

Medicinal grade yellow and white petrolatum (soft paraffin) were tested for dermatoxic effects on laboratory animals and man. Yellow petrolatum produced redness, thickening of skin, hyperkeratosis and reversible total hair loss in rabbit and rat but no dermatoxic effect was observed in man and dog. White petrolatum which is similar in composition to yellow petrolatum produced less redness and keratosis. Refluxing of yellow soft paraffin with 95% alcohol could dissolve out dermatoxic fraction. The results have been discussed and it is suggested that drugs with petrolatum as ointment base should not be tested on rats and rabbits as petrolatum itself is dermatoxic in these species.

Administration, Cutaneous↗
PubMed1976

Effect of prolonged trifluoperazine, imipramine and haloperidol administration on serum cholesterol. An experimental study in rabbits.

As a result of prolonged intragastric administration of trifluoperazine (TFZ) and imipramine in rabbits, a significant rise in serum cholesterol was observed after 4, 8 and 12 weeks. Haloperidol was ineffective. Hypercholesterolemia produced by TFZ was not associated with increased estriol excretion in urine. Histochemical examination of aorta of TFZ-treated animals showed positive 'Schultz's reaction' for cholesterol, suggesting a possible causal relationship between TFZ-induced hypercholesterolemia and atherogenesis.

Animals↗
PubMedDate not supplied

Symmetry C18 column: a better choice for the analysis of indole alkaloids of Catharanthus roseus.

By virtue of the different elution patterns of vindoline, catharanthine, vincristine and vinblastine present in the leaves of Catharanthus roseus plants, a Symmetry C18 column provided a better resolution for all of these compounds as compared with other C18 columns. The binary gradient system with a linear gradient profile, employed in a method developed using a Symmetry C18 column, gave excellent peak symmetry, resolution and reproducibility. Detection was performed at 220 nm which presented better absorptivity for these indole alkaloids giving a minimum detection limit of 0.5 microgram. Photodiode array detection was used to determine the homogeneity and purity of each compound. The described analysis is rapid and economical to perform as small amounts of solvent are consumed per analysis, and the method will find application where a large number of samples are to be analysed as, for example, in crop improvement studies where plants need to be selected regularly on the basis of alkaloid production.

Apocynaceae↗