Antidepressant agents. V. 1,1-Dimethyl-omega,omega-diphenylalkylamines.
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Biomedical subjects
Publications and source records attributed to S B Ross.
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Dopamine-beta-hydroxylase (DBH) the enzyme responsible for the biosynthesis of noradrenaline from dopamine, was assayed in the blood plasma of 19 cases with hypertension before and during beta-receptor blockade. Propranolol was given to 15 patients and I.C.I. 66,082 (a new cardioselective beta-adrenergic blocker without intrinsic sympathomimetic properties) to 4 patients. - There was no effect by the drugs on the level of plasma DBH activity in spite of a good reduction of the blood pressure.
The effect of p-chloroamphetamine (PCA) on the acquisition of a conditioned avoidance response in the rat was examined. Eleven rats were injected with saline or 2 X 10 mg/kg of PCA i.p. on two consecutive days and the learning procedure was started eight days later and lasted for six days. The acquisition of the conditioned avoidance response was strongly impaired by PCA compared with the control group. It is suggested that the impaired learning is due to a long-term effect of PCA on a 5-hydroxytryptamine system directly or indirectly linked to learning.
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