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Biomedical subjects

S B Reed

Publications and source records attributed to S B Reed.

9 recordsLinked to original sources
PubMed1992

Amyloidosis: current approaches for diagnosis and treatment.

Amyloidosis is a complex disease resulting from the extracellular deposition of fibrous degradation proteins in body tissues. The type of protein deposited determines the class of amyloidosis present. Morphological, cytochemical, and immunohistochemical studies allow one to precisely identify the class of amyloid present and, therefore, more appropriately select a therapy. Rectal biopsy is the preferred initial procedure for obtaining tissue for study; however, subcutaneous fat pad, gingival, skin, and bone marrow biopsies are alternative noninvasive biopsy sites. We have presented two patients with multiple myeloma and amyloidosis of the AL type. One patient presented with multi-organ failure of undetermined etiology and the other with asymptomatic hepatosplenomegaly. The diagnosis of amyloidosis was made by bone marrow biopsy in the first patient and rectal biopsy in the second patient using morphological studies and confirmed cytochemically with the congo red stain. The type of amyloidosis was determined with immunohistochemical studies. Their clinical course and response to therapy will be assessed by repeated immunoglobulin studies, liver and spleen size, and studies for organ dysfunction such as 2-D echo and level of proteinuria.

Amyloidosis↗
PubMed1990

Potential for alterations in family process: when a family has a child with cystic fibrosis.

Cystic Fibrosis (CF) is a disease that has profound consequences on a family unit. As a genetically transmitted, chronic illness, it influences every aspect of family life, including time constraints, finances, and relationships among family members. The purpose of this article is to demonstrate the cumulative effect of the nursing diagnoses related to the pathophysiology of CF on the nursing diagnosis, Potential for Alterations in Family Process, when a family has a child with cystic fibrosis. This nursing diagnosis was first recognized by the North American Nursing Diagnosis Association (NANDA) in 1982. It is vital that nurses be able to differentiate between a family having difficulty coping with a child with CF in the home, and one that is coping well on its own. The children of families that are not coping well tend to be hospitalized more than those of families that are coping well. The families use the hospitalizations as rest periods for themselves. By recognizing the cues identified by NANDA of a family having problems, early intervention can be initiated before the family is in a crisis. The family must live with CF on a daily basis for the remainder of the child's life; therefore it must be able to function at its optimum level. It is nursing's responsibility to be able to recognize and assist the family in need. A knowledge of the nursing diagnosis, Alterations in Family Process, will assist nurses in fulfilling this obligation to the family.

Adaptation, Psychological↗
PubMed1978

An in-vitro model of malignant hyperthermia: differential effects of inhalation anesthetics on caffeine-induced muscle contractures.

Clinical concentrations of anesthetics augment caffeine-induced contracture of frog sartorius muscle; however, anesthetics differ in this characteristic. The potentiation was quantitated using six paired sartorius muscles for each specified concentration of anesthetic and controls. At a concentration of 1 MAC, the greatest potentiation occurred with 2 mM caffeine for all anesthetics studied. Under these conditions the order of magnitude of augmentations was: chloroform (15 times); halothane (11 times); methoxyflurane (10 times); cyclopropane (5 times); enflurane (4 times); isoflurane (3 times); diethyl ether (2 times); Baxter 3224 (2 times); fluroxene (1.4 times); nitrous oxide (1.3 times). Halothane at .5 MAC augments the 2 mM caffeine-induced contracture almost seven times, and at 2 MAC almost 13 times, whereas 2 MAC isoflurane potentiates the caffeine-induced contracture only four times and 4 MAC diethyl ether only two and a half times. It is postulated that those anesthetics that most potentiate caffeine-induced contracture may be the most potent triggering agents of malignant hyperthermia.

Anesthetics↗
PubMed1976

Trace concentrations of halothane in human breast milk.

Halothane concentrations of 2 p.p.m. have been found in the breast milk of a lactating, practising anaesthetist. This concentration was consistent with the operating theatre environment. The authors fell that, in spite of the limited scope of the study, this is an additional reason for the elimination of waste anaesthetic agents from the operating theatre.

Air↗
PubMedDate not supplied

Potential for alterations in family process: when a family has a child with cystic fibrosis.

Cystic fibrosis (CF) is a disease that has profound consequences on a family unit. As a genetically transmitted, chronic illness, it influences every aspect of family life, including time constraints, finances, and relationships among family members. The purpose of this article is to demonstrate the cumulative effect of the nursing diagnoses related to the pathophysiology of CF on the nursing diagnosis, Potential for Alterations in Family Process, when a family has a child with cystic fibrosis. This nursing diagnosis was first recognized by the North American Nursing Diagnosis Association (NANDA) in 1982. It is vital that nurses are able to differentiate between a family having difficulty coping with a child with CF in the home, and one that is coping well on its own. The children of families that are not coping well tend to be hospitalized more than those of families that are coping well. The families use the hospitalizations as rest periods for themselves. By recognizing the cues identified by NANDA of a family having problems, early intervention can be initiated before the family is in a crisis. The family must live with CF on a daily basis for the remainder of the child's life; therefore it must be able to function at its optimum level. It is nursing's responsibility to be able to recognize and assist the family in need. A knowledge of the nursing diagnosis, Alterations in Family Process, will assist nurses in fulfilling this obligation to the family.

Adaptation, Psychological↗