Circulating T6 antigen positive cells.
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Adult↗
Biomedical subjects
S B Palder
Publications and source records attributed to S B Palder.
The effect of short term postoperative intravenous feeding upon cell-mediated immunity and serum suppressive activity in well nourished patients.
Thirty-four patients undergoing elective abdominal aortic aneurysmectomy were studied, and they were randomly allocated to a "fed group receiving amino acid dextrose solutions intravenously and fat emulsions or an "unfed" group receiving standard postoperative care. Cell-mediated immunity was measured by lymphocyte count, the in vitro response to the T-cell mitogen PHA and determination of T-cell subsets using monoclonal antibodies. Serum suppressive activity was measured by the ability of the sera of the patient to suppress the response of normal lymphocytes to PHA. Feeding was continued for three to five days postoperatively until satisfactory oral intake was achieved. There was no significant improvement in lymphocyte count or blastogenesis postoperatively in the "fed" group, and operation did not lead to any alteration in the ratio of T-cell subsets, although there was a fall in T-cell count (OKT3 positive cells). We conclude that short term parenteral nutrition in well nourished patients, postoperatively, does not abrogate the depression of cell-mediated immunity which occurs after extensive operative procedures.
Aged↗
Effect of extracorporeal membrane oxygenation on body water content and distribution in lambs.
Water content of the various body compartments were estimated immediately after beginning extracorporeal membrane oxygenation (ECMO), and daily thereafter for 3 days, in seven healthy 2-month-old lambs. Total body water, extracellular water, and plasma volume were estimated simultaneously by 18O, bromide, and T-1824 dilution, respectively. Volumes of intracellular water, interstitial water, blood, and red cells were calculated from the experimental estimates. No statistically significant changes occurred in the water content of the various body compartments in relation to duration of ECMO. The data suggest that water retention, clinically noted in human neonates treated with ECMO for persistent pulmonary hypertension, may be related to the primary disease process and/or its medical management, rather than to ECMO.
Animals↗
Prolonged extracorporeal membrane oxygenation in sheep with a hollow-fiber oxygenator and a centrifugal pump.
ECMO with a roller-pump employs two potentially thrombogenic devices: the servoregulator bladder and heat exchanger. To eliminate these we used an 0.8 m2 Capiox II hollow-fiber oxygenator ventilated with warmed humidified oxygen and a Bio-Medicus centrifugal pump with a 1/4 inch head at a flow of 250 cc/min in six sheep during 96 hr of ECMO each. Oxygenator performance and plasma Hgb were determined, as were the volume, electrolyte, and protein content of fluid accumulating in the gas phase of the oxygenator. Mean oxygen transfer was 15.78 +/- 3.15 ml/min, and mean differences in PaO2 between blood entering and leaving the oxygenator was 360 +/- 49 mmHg. Mean plasma Hgb was 24.7 +/- 12.8 mg/dl. Fluid in the gas phase of the oxygenator was less than 75 ml/day and contained no albumin, protein, sodium, potassium, or chloride. Centrifugal pumps have been associated with hemolysis at low flows, but this may have been due to the simultaneous use of silastic membrane oxygenators that have high resistance. Hollow-fiber oxygenators have been associated with early failure of gas exchange and fluid accumulation in the gas phase. This may have been due to ventilation with dry gas. We conclude that a hollow-fiber oxygenator and a centrifugal pump can provide excellent gas exchange, acceptable hemolysis, and little fluid loss.
Animals↗