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Biomedical subjects

S B Larsen

Publications and source records attributed to S B Larsen.

30 records · Page 2Linked to original sources
PubMed1995

Expectations and knowledge of pelvic examinations in a random sample of Danish teenagers.

The purpose of the study was to describe teenagers' expectations and knowledge of the pelvic examination (PE). The study was carried out as a cross-sectional postal questionnaire study. A total of 1500 women, aged 17 years, were selected at random from all Danish women of that age. The response rate was 76%, and 551 of these 1112 teenagers had experienced their first PE. Among the teenagers who had not had a PE, 48% thought the examination would be painful, 29% feared that the doctor would discover abnormal anatomy, 67% felt they would be embarrassed by exposing their genitals and 23% expected to be indisposed for the rest of the examination day. Among the teenagers who had not experienced a PE, only 17% felt that they had sufficient knowledge of the examination, compared to 68% in the group who had already experienced an examination. In the group who had not experienced a PE 33% knew what the doctor was able to inspect during the instrumental part of the examination, compared to 55% in the other group with experience. It is concluded that a considerable proportion of teenagers have negative expectations of the PE, and increased effort to improve teenagers' expectations and knowledge of the PE may be recommended.

Adolescent↗
PubMed1993

[Ambulatory psychiatry--a follow-up after 1 year].

This article describes the results of a one year follow-up investigation of patients suffering from psychiatric and mental diseases and psycho-social problems who were seen in general practice or by private practising psychiatrists and the psychiatric outpatient hospital clinic in a Danish county. 40-50% of the patients concluded treatment within the first year. The general practitioner and the private practising psychiatrist saw 10% of the patients more than 13 times. In the outpatient hospital clinic, 10% of the patients were seen more than 29 times. A psychotherapeutic approach to treatment was employed for 54-90% of the cases. Psychopharmacological medication was administered to 54-60% of the patients. Where patients in general practice and in the outpatient clinic were concerned, treatment in an emergency open unit and treatment in sheltered environments was required and supervision was necessary for 1/4 of the cases. The investigation demonstrates the role of the general practitioner in treatment and referral. After one year 25% of the patients were referred for other treatment. The general practitioner, private practicing psychiatrist and outpatient clinic treat different groups of psychiatric patients and work somewhat independently of one another.

Adolescent↗
PubMed1992

Paroxetine and imipramine in the treatment of depressive patients in psychiatric practice.

A total of 151 outpatients with endogenous or mixed endogenous and reactive depression were included in a 6-week double-blind study, with extension for up to 1 year, in psychiatric practice. The results showed trends in efficacy variables and a statistically significant difference in a benefit-risk ratio in favour of paroxetine (Seroxat, Paxil) compared with imipramine. Efficacy was largely maintained in both groups during long-term treatment. The frequency and severity of side effects in paroxetine patients declined markedly from short-term to long-term treatment, whereas changes in imipramine patients were less pronounced. Significantly more imipramine patients gained weight during long-term treatment. In conclusion, paroxetine is an effective and well tolerated antidepressant, well suited for outpatients in psychiatric practice.

Adolescent↗
PubMed1991

Treatment of recurrent acute tonsillitis with clindamycin. An alternative to tonsillectomy?

The failure of treatment with penicillin in patients suffering from acute beta-haemolytic streptococcus Group A tonsillitis, may be due to the presence of beta-lactamase-producing bacteria. Several studies indicate that treatment with clindamycin may prevent recurrence and thereby eliminate the need for tonsillectomy. In this prospective study, 54 patients with recurrent acute tonsillitis were investigated. 29 patients were treated with clindamycin, 150 mg 4 times daily for 10 days, while 25 patients received no antibiotic treatment and served as a control group. A significantly reduced number of episodes of acute tonsillitis (P less than 0.01) and of tonsillectomy (P less than 0.001) was found in the group of patients treated with clindamycin.

Acute Disease↗
PubMed1989

[Sectorized psychiatry. Ambulatory psychiatry in a geographically defined region].

The article describes the psychiatric outpatient treatment service in the catchment area of the county of Roskilde in Denmark. Eighty-four general practitioners, ten private practising psychiatric specialists and the psychiatric outpatient service at Roskilde Amts Sygehus Fjorden participated in a prospective cohort study based on questionnaires. This includes 404 patients from general practice, 326 from the psychiatric specialists and 166 from the psychiatric hospital. The patients' social conditions, demographic data, psychosocial problems, psychosocial strain, diagnoses, and the treatment are presented. Psychotics constitute 52% of the patients from the outpatient treatment service corresponding to 25% from specialist practice and 12% from general practice. The most common diagnoses at specialist level are neuroses and crises, in general practice, in addition, psychosomatic illness and depression without psychoses. The treatment for most of the patients is psychotherapy or in combination with psychopharmacology. Further acute psychiatric service and supervision are required. One year follow-up has been accomplished. Follow-up reviews after five and ten years are planned.

Adolescent↗
PubMed1987

Suriclone and diazepam in the treatment of neurotic anxiety. A double-blind cross-over trial.

Suriclone is a new anxiolytic drug belonging to the family of cyclopyrrolones. Although chemically entirely different from the benzodiazepines, it acts as a benzodiazepine agonist with very high affinity for the benzodiazepine receptors. In the present cross-over study, 33 out-patients with a diagnosis of neurotic anxiety were treated with suriclone (mean dose 2 mg/day) and diazepam (25 mg/day) in two 6-week periods. Both drugs had a significant anxiolytic effect, but diazepam appeared to have a better effect within the first 2 weeks of treatment, while no significant difference was seen after treatment, while no significant difference was seen after treatment for 6 weeks. Suriclone and diazepam had a different side effect profile: suriclone produced mainly dizziness, while diazepam caused sedation. This may reflect the fact that suriclone and benzodiazepines bind to distinct sites or different allosteric conformations of the benzodiazepine receptors.

Adult↗
PubMed1981

Analysis of information in indicant-patterns.

Different patterns of information may lead to identical diagnostic conclusions, but it remains uncertain whether such patterns will have the same validity towards other criteria, e.g. choice of treatment. A procedure for selection of optimal patterns of data and analysis of their validity towards different criteria is described. It is founded on Bayes' methodology and characterized by a continuous correction for redundancy between indicants. Permissible patterns/syndromes are formulated and evaluated in a consistent way.

Diagnosis, Computer-Assisted↗
PubMed1981

Evaluation of data-base.

The records of 421 psychiatric patients were analysed by a consistent method, allowing an optimal use of indicant-patterns. It was assumed that such a procedure would give a satisfactory predictive capacity, even for operational criteria as for example choice of treatment, duration of stay in hospital, or a global evaluation of outcome. The study demonstrates, however, that fundamental changes in the data-base are necessary. Problems of reliability, validity, sensitivity and specificity are discussed and some suggestions are offered for the future improvement of psychiatric data-bases.

Diagnosis, Computer-Assisted↗
PubMedDate not supplied

A longitudinal study of semen quality in pesticide spraying Danish farmers. The ASCLEPIOS Study Group.

It was hypothesized that occupational exposure to pesticides during a spraying season causes changes in semen quality that might be detected in a longitudinal study. We analyzed the within-person changes in semen quality and reproductive hormones across a spraying season in groups of farmers using and not using pesticides. A total of 248 men collected two semen samples (participation rate: 32%). The median sperm concentration declined significantly from the first to the second sample in both groups, but there was no statistical difference in the decline between the two groups, unadjusted or adjusted. Only minor changes were found in sperm morphology, vitality, motility, sperm chromatin denaturation (SCSA), and reproductive hormones, and the differences in changes between the two groups were nonsignificant, or, in the opposite direction to the expected. There was no relation between the changes in sperm parameters in relation to pesticide exposure variables. In conclusion, use of pesticides by Danish farmers is not a likely cause of short-term effects on semen quality and reproductive hormones.

Adolescent↗