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Biomedical subjects

S B Korones

Publications and source records attributed to S B Korones.

At least 73 records · Page 4Linked to original sources
PubMed1983

Evolution of nursery design and function. The Memphis story.

The total design of a neonatal special care unit is fundamentally determined by patient load, essential staff, fiscal wherewithal, and available space. Given a commitment to this type of care, the least controllable of these factors are patient load and essential personnel. Suggestions for the design of these units can be made only in terms of effective function of personnel and optimal care of infants. The encapsulated account of our evolution is intended to present the rationale of our decisions. A straight-forward unembelished description of these physical facilities would not be meaningful without continuous reference to the staff and the infants that bring a facility to life.

Hospital Bed Capacity, 500 and over↗
PubMed1980

Pharmacokinetics of nafcillin in infants with low birth weights.

The pharmacokinetics of nafcillin were studied in 13 premature neonates with suspected sepsis. The mean weight of the infants studied was 1.19 kg (range, 0.73 to 2.21 kg). Infants less than 7 days of age were given 100 mg of nafcillin per kg per 24 h (every 12 h), and infants more than 7 days of age were given 100 mg of nafcillin per kg per 24 h (every 8 h). Blood samples were obtained before the first dose on day 3 of therapy and at 0.5, 1.5, 3, and 6 h thereafter. Nafcillin concentrations were measured by a microbiological assay. A mean volume of distribution of 326 ml/kg and an elimination rate constant of 0.2040 h-1 were obtained in 10 patients less than 21 days of age. Three patients from 24 to 68 days of age had a mean volume of distribution of 303 ml/min and a mean elimination rate constant of 0.3944 h-1 (P less than 0.05). These data suggest that doses of nafcillin lower than those currently recommended may be adequate to achieve desired peak plasma levels of approximately 75 microgram/ml in infants with low birth weights.

Age Factors↗
PubMed1977

Measurement of intragastric oxygen concentration for the diagnosis of H-type tracheoesophageal fistula.

The demonstration of an H-type tracheoesophageal fistula before surgical correction is frequently difficult. Currently utilized procedures are so irregularly successful that surgical exploration is sometimes necessary without prior demonstration of the fistula. A case is reported in which the diagnosis was made by measurement of intragastric oxygen concentration, which increased and declined in response to the endotracheal insuffation of 100% oxygen and room air, respectively. The fistula was subsequently demonstrated by barium esophagram and was successfully treated surgically. In the presence of the classic clinical triad (choking during feedings, abdominal distention, and pneumonitis), a positive intragastric oxygen test may be sufficient indication for surgical exploration.

Female↗
PubMed1976

Early diagnosis of necrotizing enterocolitis.

This study demonstrates that the diagnosis of necrotizing enterocolitis can sometimes be made before the full-blown clinical and radiographic findings are manifest. Of 12 infants with films available prior to diagnosis of the disease, nine had early selective dilatation of small bowel and little or no air in the colon. Necrotizing enterocolitis should be foremost in the differential diagnosis when this finding is coupled with signs such as abdominal distention, acidosis, and diarrhea.

Enterocolitis, Pseudomembranous↗
PubMedDate not supplied

Epidemic Serratia marcescens in a neonatal intensive care unit: importance of the gastrointestinal tract as a reservoir.

Between a March and December of 1979, and outbreak of infections due to multiply antibiotic resistant Serratia marcescens took place in a 50-bed neonatal intensive care unit. Fifteen neonates suffered major infections (sepsis, meningitis and pneumonia) with one death, and 20 suffered minor infections (conjunctivitis, cystitis, wound infections). Epidemiologic investigation failed to reveal a common source; S. marcescens, however, ws isolated from an employee's hand, emollient skin cleanser, suction tubing, and three in-use manual infant resuscitation bags. The skin cleanser and equipment-cleaning agents were ineffective against S. marcescens. Asymptomatic, colonized infants were the major reservoir of S marcescens. These infants were identified by daily cultures of the nose, umbilicus and rectum. The rectal swab most commonly (76%) yielded first-positive cultures in previously uncolonized infants, and was ultimately positive in 92% of colonized infants. A control program was begun by: 1) removing all inanimate sources of S. marcescens; and 2) cohorting patients and staff into a S. marcescens-exposed group and a new patient group. The new patient group of infants was surveyed by daily triple-site cultures for colonization and subsequent transfer to the S. marcescens-exposed group. After four months, the epidemic was controlled and the organism eradicated from the neonatal intensive care unit.

Cross Infection↗