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Biomedical subjects

S B Gusberg

Publications and source records attributed to S B Gusberg.

At least 55 records · Page 3Linked to original sources
PubMed1977

Radiosensitivity testing, virulence indices, and stromal reaction in carcinoma of the cervix uteri.

A relatively simple, clinically applicable, analytic-pathologic approach to the complex problem of carcinoma of the uterine cervix is given. Careful study of control and post-test radiation cervical biopsies and evaluation of the type and grade of the carcinoma, the lymphatic vessel involvement, the stromal host reaction, and the tumor response to test radiation offer additional parameters in the therapeutic approach, aiming at the improvement of prognosis. We also hope that this work offers a contribution to the complex problem of tumor biology and pathology.

Biopsy↗
PubMed1976

The individual at high risk for endometrial carcinoma.

Epidemiologic studies can help us recognize high-risk factors in endometrial carcinoma. The definition of high-risk factors, especially at the menopause,can lead to prophylactic measures that may aid in the control of this disease. This recognition of the high-risk patient in the perimenopausal years may be aided by aspiration curettage of ambulatory women, for such a strategy of surveillance is practical and efficient. Increasing acceptance of hormone sensitivity in neoplastic abnormality of the endometrium can also influence us in identifying the patient at risk.

Adult↗
PubMed1976

The evolution of modern treatment of corpus cancer.

The treatment of endometrial cancer has been surgical, traditionally, with preoperative radiation gaining favor in the past three decades. This surgical treatment has been confined to simple hysterectomy and bilateral salpingo-oophorectomy in most clinics because of the pattern of spread of corpus cancer and the alleged benignity of this disease. Even now, the role of radical surgery, the timing of radiation therapy and its mode, and the place of hormonal treatment for primary disease are still the subject of discussion and clinical investigation. The definition of virulence factors and an appropriate staging dependent upon these factors has helped to clarify some of these problems and will help the analysis of cure rates when we can understand the selection of the material. With such a prospect for quality control and establishment of a protocol of individualization of treatment, we have a right to expect that appropriate surgical and radiotherapeutic measures will gain their proper priority and adjuvant hormonal therapy and chemotherapy may be incorporated.

Female↗
PubMed1975

Screening for endometrial cancer.

Since Gusberg's description in 1947 of adenomatous hyperplasia (15), the role of precursors in the development of endometrial carcinoma has been well studied. There is now no doubt that in many patients histologic precursors can be demonstrated in the endometrial cavity prior to the development of invasive cancer. At this point in the continuum, interruption by hysterectomy or other therapy will insure the patient's health. We have discussed a wide variety of techniques designed to provide cytologic or histologic samples of the endometrium that are highly effective in the detection of early neoplasia. As a goal, universal endometrial sampling on a periodic basis is probably impractical and may be unecessary or undesirable. However, surely the patient at high risk for endometrial cancer requires close periodic screening. The high-risk category may be expanded to include others beyond the group of hypertensive, diabetic, obese, anovulatory, nulliparous women. It should include patients with irregular vaginal bleeding, those with a strong family history of genital and breast cancer, those patients receiving hormone therapy, and patients in the menopausal years who experience changes in the menstrual pattern. With intelligent and aggressive application of outpatient screening, uterine cancer can be diagnosed when patients are virtually completely curable, thus resulting in further reduction in mortality from this disease.

Adenocarcinoma↗
PubMed1975

President's remarks.

Explore the source record for details and available documents.

Academies and Institutes↗
PubMed1975

A strategy for the control of endometrial cancer.

Epidemiologic studies can provide us with etiological clues and help us recognize high risk factors. The definition of high risk factors, especially in the perimenopausal years can lead to prophylactic measures that may aid in the control of endometrial cancer. Recognition of the high risk patient in the perimenopausal years by aspiration curettage of ambulatory women may offer a significant strategy of surveillance. The advent of modern steroid metabolic technology promises to help us clarify the problems of hormone sensitivity of this tumor so that we may properly translate these data into therapeutic action. Virulence scales can help the choice of treatment for invasive carcinoma so that patients with tumors of low virulence do not suffer from an excess of complications nor those with tumors of high virulence an excess of failure to control. In this manner we can define the role of radiotherapy and surgery, elect combined treatment when indicated and select radical surgery as indicated. There is evidence to suggest that the developmental concept of this tumor may lead to its control in a manner similar to that occurring with cervix cancer.

Adenoma↗