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Biomedical subjects

S B Goren

Publications and source records attributed to S B Goren.

14 recordsLinked to original sources
PubMed1988

Diagnostic tests in patients with symptoms of keratoconjunctivitis sicca.

We compared the relative value of the tear film breakup time, Schirmer test, lactoferrin immunologic assay and rose bengal staining in 156 patients with varying severity of symptoms characteristic of keratoconjunctivitis sicca and in 39 controls. Statistical analysis showed that in patients with minimal ocular irritation the Schirmer test in combination with the lactoferrin immunologic assay provided an optimal balance between high test sensitivity and low false-positive rates. In patients with moderate to severe ocular burning, foreign body sensation, or pain but with no systemic symptoms of dry mouth or arthritis, and in patients with both ocular and systemic complaints, the lactoferrin assay alone provided statistically significant results. Tear film breakup time and staining with rose bengal were not useful and the Schirmer test had limited value in measuring the rate of tear secretion in these patients.

Adult↗
PubMed1979

The inhibition of corneal vascularization with aortic extracts in rabbits.

A low molecular weight fraction of bovine aortic extract inhibited corneal vascularization and edema in rabbits when administered either subconjunctivally or topically as long as 48 hours after injury. The extract also appeared to enhance the regression of newly formed corneal vessels. Topical administration for as long as two months had no deleterious ocular side effects. Tissue culture experiments showed that analagous fractions prepared from bovine vitreous inhibit endothelial cell growth. The major growth inhibitor of corneal neovascularization was not the Kunitz bovine protease inhibitor.

Animals↗
PubMed1977

The inhibition of corneal vascularization in rabbits.

A single subconjunctival injection of 250 microgram of a partially purified extract of bovine aorta, administered immediately before or after silver nitrate injury to the cornea, markedly inhibited corneal vascularization in the rabbit eye. We believe the active molecule is a protease inhibitor that prevents the potential source of new vessels from proliferating and invading the diseased cornea.

Animals↗
PubMed1975

Cataract associated with long-term facial paralysis.

Of 29 patients with postoperative acoustic neuroma, five patients with facial paralysis developed unilateral lens opacities of unknown etiology on the paralyzed side, one to six years after surgery. The corneas were well maintained in all patients by means of either eyelid surgery or flush-fitting scleral contact shells. Four patients had anterior subcapsular opacities and in one patient a mature cataract developed. Thus, cataracts may be associated with long-term facial paralysis.

Aged↗
PubMed1975

The red eye.

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Acute Disease↗
PubMed1966

Blowout fractures of the orbital floor.

Six patients with blowout fractures of the orbital floor, not associated with infraorbital rim fractures, are presented. Diplopia, infraorbital anesthesia and enophthalmos following blunt trauma to the eye should alert the examiner to the possibility of a blowout fracture with incarceration of extraocular tissues. Early roentgenographic examinations are often difficult to evaluate because of periorbital edema, mucosal swelling and antral hematoma. In cases in which stereoscopic Waters projections are equivocal, laminograms of the orbit, after the edema subsides, will aid in confirming the diagnosis. Forced ductions will often ascertain whether or not there is impingement of extraocular tissues in the fracture site. If there is no clinical evidence of incarceration or impingement of extraocular tissues, but only radiographic suggestion of a blowout fracture, there is a possibility that surgical intervention may be deferred and the patient carefully watched. However, early recognition and treatment of soft tissue incarcerations is necessary in order to avoid persistent diplopia, enopththalmos, and late cosmetic deformity.

Adolescent↗