Biomedical subjects

S B Frank

Publications and source records attributed to S B Frank.

At least 19 recordsLinked to original sources

PubMed1989

Exudative discoid and lichenoid chronic dermatitis: does it exist or should it be discarded?

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Adult↗

PubMed1982

Is the rabbit ear model, in its present state, prophetic of acnegenicity?

The rabbit ear model has been proposed as a useful bioassay to establish the comedogenic and acnegenic qualities of chemical compounds and finished products, pharmaceutical and cosmetic, for topical application. This review highlights the many problems in performance of the test method, the absence of correlation with experience in the human, and, consequently, the serious limitations of the conclusions that can reasonably be drawn, especially for the clinical dermatologist.

Acne Vulgaris↗

PubMed1977

Treatment of acne with topical antibiotics.

The introduction of topical antibiotics for acne vulgaris has ushered in a new era in the treatment of this troublesome disorder. Tetracycline, erythromycin, and clindamycin can now be prepared in lotion form in vehicles that are capable of carrying the antibiotic into the follicular canal, where the primary lesion of acne occurs. Topical antibiotics are practically as effective as oral antibiotics in treating acne and are particularly useful for mild papular acne of puberty and early adolescence and papular-pustular acne of adult women. Use of topical antibiotics avoids the possibility of the adverse effects of systemic therapy; the side effects from the formulations reported here are negligible. Above all, antibiotic lotions do not produce the dryness and scaling that occur with most other topical acne preparations.

Acne Vulgaris↗

PubMed1977

An update on acne vulgaris.

Seven important therapeutic measures in managing acne are described, for the treatment of the 7 types of acne. These therapeutic measures are retinoic acid, benzoyl peroxide gel, topical antibiotics, oral antibiotics, intralesional corticosteroids, liquid nitrogen and oral corticosteroids.

Acne Vulgaris↗

PubMed1976

Topical treatment of acne with a tetracycline preparations: results of a multi-group study.

This report presents the results of a 13-week study done on 300 patients with acne vulgaris treated with a tetracycline topical lotion alone. The vehicle used was an aqueous-ethanol solution containing the penetration enhancer, n-decyl methyl sulfoxide. On a 0-8 grading scale, 81% of the patients improved by one or more grade points, 57% by two or more points and 31% by three or more points. Analysis indicated that concomitant variables such as severity, age, type of acne, sex and season of the year did not alter the conclusion as to efficacy. Detailed statistical analysis indicates that the conclusion is valid that the tetracycline preparation is beneficial in the treatment of acne vulgaris. No adverse reactions were observed in the patients treated. Hemograms, blood studies and urinalyses were completed on 37 patients. No disturbing trends were uncovered.

Acne Vulgaris↗

PubMed1975