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S B Curri

Publications and source records attributed to S B Curri.

At least 73 records · Page 4Linked to original sources
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The structure of fat.

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Adipose Tissue↗
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[Venous stasis and panniculopathy: a semiologic study].

The relevant role played by the microcirculation on several pathologies and on the genetic evolution of rarely known diseases as the panniculopathy with venous stasis have been explained. It represent a support on the concept for new research of microcirculation's injuries as a primary factor on macrophlebopathies.

Adipose Tissue↗
PubMedDate not supplied

[Microvascular anatomy of the skin and its appendages].

The microcirculatory bed of the skin has traditionally been divided into small arteries, precapillary arterioles, capillaries and venules. Also the most recent classification emphasize that the blood supply of the human dermis is a microcirculatory bed. Therefore, considering for example the skin of the lower limbs, there are too much anatomic and topographic peculiarities of the skin and subcutaneous tissue, so that a generalization of the microcirculatory patterns appears to be illusory and misleading. In fact, the foots plant is a "special microcirculatory region", and so the finger tips and the nail beds. Rich on arterio-venous anastomoses, on endoarterious blocking devices regulating the capillary blood flow, this "microcirculatory region" is characterized by haemodynamic patterns which are not comparables with those of other regions where AVA or other "special vessels" are absent. The microangiotectonic, i.e. the distribution in the tridimensional space of the dermis, adipose tissue and muscle of the smallest blood vessels show relevant differences in the foots, legs, knees or thighs. Normally, it is admitted that the majority of the papillary dermal vessels are postcapillary venules, but the ultrastructure of the arterioles and venules in the mid and lower dermis differs from the ultrastructure of comparable vessels of the deeper layers or of the subcutaneous fat. For these reason and on the basis of bioptic specimens of the skin, adipose tissue and muscles of the whole lower limbs, the subdivision in "microcirculatory regions" is proposed. The criteria are the presence or absence of AVA, the structure and localization of the endoarterious blocking devices, the structure of valve-containing venules and the microvessels-tissue relationship. Computerized Laser-Doppler Flowmetry and infra red Photo-Pulse Plethysmography, computerized Telethermography with physical stimulations, High Performance Contact Thermography and continuous registration of the skin temperature associated with pharmacological vasoactive stimulation, are helpful to identify and characterize functionally the "microcirculatory regions" of the lower limbs.

Capillaries↗
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A new capillaroscopic assessment of microvascular damage vs Maricq classification in patients with isolated Raynaud phenomenon.

A new classification for microvascular lesions assessment by means of capillaroscopy is proposed in this research. The new method, offering a numerical score for microvascular lesions, was used in patients affected by isolated Raynaud Phenomenon (RP). RP can often be associated with scleroderma and, therefore, the new classification has been compared to the Maricq one for what concerns this connective tissue disorder. The numerical method is as sensitive as that by Maricq, but, as easily expected, its specificity is quite low. It appeared to be satisfactory also the positive predictive value of the new capillaroscopy classification combination with the clinical examination and with the immunologic biohumoral investigation. It is particularly easy to apply this method, as it presents to the examinator a restricted range of answers, for the capillaroscopic picture description, but it needs further studies in different microcirculation damages to be proved definitely valuable.

Arterioles↗
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[Microcirculatory changes in Bureau-Barrière disease and alcoholic polyneuropathy. Preliminary note: correlations and pathogenic hypotheses].

Nosologically, in ulcerative-mutilating acropathies (U.M.A.), it is customary to differentiate the usual forms of the disease (Thevenard's disease) which develop primarily and the secondary forms (U.M.A. or, better, pseudo-U.M.A.), in which the syndrome is secondary to a known pathologic process and which represent a symptom and not a disease. The link between these two nosological entities is the pseudo-syringomyeli U.M.A. of the lower extremities, or Bureau-Barrier's disease. This disease is exclusively seen in alcoholics and is similar to the neurological alterations observed in alcoholic polyneuropathies. Some authors consider this form as an ulcerative-mutilating acropathy (symptomatic U.M.A.). The objective of our research is to demonstrate the similarity between the microcirculation alterations in patients with Bureau-Barriere's disease and patients with alcoholic polyneuropathy without trophic lesions. For this purpose, we have biopsied the pulp of the great toe, according to the method described by Curri-Schendorf in three patients with Bureau-Barriere's disease, 46, 50 and 65 year-old respectively, and three patients with alcoholic polyneuropathy, 34, 54 and 63 years-old respectively. All these patients presented a normal macrocirculation, without any diabetes, nor disease prone to alter the microcirculation. The results obtained, in a limited series however, permit to state that it is possible to unify alcoholic polyneuropathy and Bureau-Barriere's disease in a single clinical and nosological entity, and to say that the latter only represents an evolution of the former. Besides, we have notices that microcirculation alterations, although non-specific, are extensive and occur early, permitting to suspect a pathogenic process related to a true alcoholic histo-angeitis which, for us, represent the pathogenic basis of Bureau-Barriere's disease.

Adult↗
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[Microvalves in microvenules].

A long-lasting histological study on muscle and cutaneous-subcutaneous biopsies allowed certain observations of microvalves in venules with a diameter ranging from 80 to 200 micron. Venular leaflets originate from the vein as extroflection of the intima, made by a single layer of endothelial cells. In the patient affected by severe chronic venous insufficiency the valvular leaflets appear thickened while the wall of the venule presents sclero-hyalinotic alterations. The presence of microvalves in venules suggests a role of their incontinence in the venous insufficiency. Considering that the venular leaflets are made just by endothelial cells, a primary pathogenetic role has to be achieved to the endotheliopathy in the genesis of venous insufficiency.

Chronic Disease↗
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[Cellulitis, a conjunctive microvascular disease].

While the term cellulitis is incorrect, it is commonly used and deserves a nosological classification. "Cellulitis is a dermohypodermosis and an oedemato-sclerous panniculopathy- It is indeed a true histangiography in which the fibroblastic reaction predominates over capillaro-veinular changes. Adipocytes of exaggerated size interpenetrate into micro- and later into macronodules marked off by more or less structured conjunctive fibrilla, thereby making treatment difficult.

Cellulitis↗